2014 Vol. 32, No. 5
Display Method:
2014, 32(5): 321-323.
doi: 10.3969/j.issn.1006-0111.2014.05.001
Abstract:
Objective Lox-1 (lectin-like oxidized low-density lipoprotein receptor-1) was one of the main receptor of ox-LDL, which took an important role in vascular endothelial dysfunction, the formation of foam cells, and the stability of atherosclerotic plaques. To investigate the role of Lox-1 in cardiovascular diseases. Methods The literatures of Lox-1 in cardiovascular diseases retrospectively were reviewed. Results As a new ox-LDL scavenger receptor, Lox-1 played an important role in cardiovascular diseases. Conclusion Lox-1 might provide new ideas for cardiovascular diseases.
Objective Lox-1 (lectin-like oxidized low-density lipoprotein receptor-1) was one of the main receptor of ox-LDL, which took an important role in vascular endothelial dysfunction, the formation of foam cells, and the stability of atherosclerotic plaques. To investigate the role of Lox-1 in cardiovascular diseases. Methods The literatures of Lox-1 in cardiovascular diseases retrospectively were reviewed. Results As a new ox-LDL scavenger receptor, Lox-1 played an important role in cardiovascular diseases. Conclusion Lox-1 might provide new ideas for cardiovascular diseases.
2014, 32(5): 324-328,400.
doi: 10.3969/j.issn.1006-0111.2014.05.002
Abstract:
Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that play a central role in host cell recognition and responses to microbial pathogens. TLRs-mediated recognition of components derived from a wide range of pathogens and their role in the subsequent initiation of innate immune responses is widely accepted, besides, the recent discovery of non-TLR PRRs, such as C-type lectin receptors, NOD-like receptors, and RIG-I-like receptors, suggests that many aspects of innate immunity are more sophisticated and complicated. In this review, we focused on the role cooperated by TLRs in mounting protective immune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition.
Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that play a central role in host cell recognition and responses to microbial pathogens. TLRs-mediated recognition of components derived from a wide range of pathogens and their role in the subsequent initiation of innate immune responses is widely accepted, besides, the recent discovery of non-TLR PRRs, such as C-type lectin receptors, NOD-like receptors, and RIG-I-like receptors, suggests that many aspects of innate immunity are more sophisticated and complicated. In this review, we focused on the role cooperated by TLRs in mounting protective immune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition.
2014, 32(5): 329-331,392.
doi: 10.3969/j.issn.1006-0111.2014.05.003
Abstract:
In recent years, many studies have found that vitamin D insufficiency is associated with osteomalacia, hypertension, diabetes, metabolic syndrome and other diseases. Vitamin D must be hydroxylated in the liver by a 25-hydroxylase for the first time, and then in the kidney by a 1α-hydroxylase for the second time to form the active metabolite 1, 25-dihydroxy vitamin D, which binds to the intracellular vitamin D receptor and exerts its effects. This paper reviewed the relationship between vitamin D and disease, present research situation of gene polymorphism of vitamin D receptor, and the advantages and limitations of several methods of vitamin D detection, and proposed the best method for detecting vitamin D receptor gene polymorphism and the importance of the detection state to guide clinicians to use drug rationally.
In recent years, many studies have found that vitamin D insufficiency is associated with osteomalacia, hypertension, diabetes, metabolic syndrome and other diseases. Vitamin D must be hydroxylated in the liver by a 25-hydroxylase for the first time, and then in the kidney by a 1α-hydroxylase for the second time to form the active metabolite 1, 25-dihydroxy vitamin D, which binds to the intracellular vitamin D receptor and exerts its effects. This paper reviewed the relationship between vitamin D and disease, present research situation of gene polymorphism of vitamin D receptor, and the advantages and limitations of several methods of vitamin D detection, and proposed the best method for detecting vitamin D receptor gene polymorphism and the importance of the detection state to guide clinicians to use drug rationally.
2014, 32(5): 332-336,359.
doi: 10.3969/j.issn.1006-0111.2014.05.004
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Objective The phosphoinositide 3-kinase (PI3K) constituted an important family of lipid kinase enzymes that control a range of cellular proliferation, differentiation and apoptosis through their regulation of a network of signal transduction pathways, which had emerged as important therapeutic targets in the context of cancer and inflammation. Considerable progress had been made in the discovery and development of small molecular inhibitors targeting PI3K. Progress in dual PI3K-mTOR inhibitors, a number of which had entered early phase clinical trials over recent years was summarized.
Objective The phosphoinositide 3-kinase (PI3K) constituted an important family of lipid kinase enzymes that control a range of cellular proliferation, differentiation and apoptosis through their regulation of a network of signal transduction pathways, which had emerged as important therapeutic targets in the context of cancer and inflammation. Considerable progress had been made in the discovery and development of small molecular inhibitors targeting PI3K. Progress in dual PI3K-mTOR inhibitors, a number of which had entered early phase clinical trials over recent years was summarized.
2014, 32(5): 337-341,371.
doi: 10.3969/j.issn.1006-0111.2014.05.005
Abstract:
Cancer is a serious threat to human life and health. Therefore, there is an emergent need to develop novel anti-cancer agents with new structural type, new mechanism of action and higher efficacy. Natural products had played a key role in the discovery of anticancer agents. The anti-cancer activity, mechanism of action, structure and activity relationship of several lead-compounds which were derived from natural products were summarized in this review.
Cancer is a serious threat to human life and health. Therefore, there is an emergent need to develop novel anti-cancer agents with new structural type, new mechanism of action and higher efficacy. Natural products had played a key role in the discovery of anticancer agents. The anti-cancer activity, mechanism of action, structure and activity relationship of several lead-compounds which were derived from natural products were summarized in this review.
2014, 32(5): 342-343,378.
doi: 10.3969/j.issn.1006-0111.2014.05.006
Abstract:
Objective To synthesize the antifungal tetrapetide by solid-phase synthesis method. Methods The solid-phase peptide synthesis was chosen for getting the desired target tetrapeptide and its structure was confirmed by MS and 1H NMR. Results The synthesis of the D-Phe-Val-D-Val-Tyr-OH was realized with yield of 47%. Conclusion The synthetic method was feasible and practical. The desired target tetrapeptide could be used for screening of antifungal activity.
Objective To synthesize the antifungal tetrapetide by solid-phase synthesis method. Methods The solid-phase peptide synthesis was chosen for getting the desired target tetrapeptide and its structure was confirmed by MS and 1H NMR. Results The synthesis of the D-Phe-Val-D-Val-Tyr-OH was realized with yield of 47%. Conclusion The synthetic method was feasible and practical. The desired target tetrapeptide could be used for screening of antifungal activity.
2014, 32(5): 344-347,351.
doi: 10.3969/j.issn.1006-0111.2014.05.007
Abstract:
Objective To screen and identify the main pro-angiogenic compounds of Shexiang Baoxin pill (SBP) presenting in the plasma. Methods The pro-angiogenic effects of SBP and its compounds absorbed into blood were measured by the cell proliferation and cell migration assays by xCELLigence. And the cell tube formation and rat aortic ring models were established to evaluate their pro-angiogenic effect. Results SBP(10-4~10-2 μg/ml), ginsenoside Rg3(1~10 μmol/L) and ginsenoside Rh2(1~10 μmol/L)significantly stimulated human umbilical vein endothelial cells (HUVECs) proliferation, migration and tube-like structures formation at different concentrations (P<0.05). In addition, compared to the control group, only the high concentration group of SBP (10-2 μg/ml), Rg3(10 μmol/L) and Rh2(10 μmol/L)could induce endothelial cell sprouting from the aortic ring(P<0.05). Conclusion SBP, ginsenosideRg3 and Rh2 exhibited significantly pro-angiogenic effect in vitro.
Objective To screen and identify the main pro-angiogenic compounds of Shexiang Baoxin pill (SBP) presenting in the plasma. Methods The pro-angiogenic effects of SBP and its compounds absorbed into blood were measured by the cell proliferation and cell migration assays by xCELLigence. And the cell tube formation and rat aortic ring models were established to evaluate their pro-angiogenic effect. Results SBP(10-4~10-2 μg/ml), ginsenoside Rg3(1~10 μmol/L) and ginsenoside Rh2(1~10 μmol/L)significantly stimulated human umbilical vein endothelial cells (HUVECs) proliferation, migration and tube-like structures formation at different concentrations (P<0.05). In addition, compared to the control group, only the high concentration group of SBP (10-2 μg/ml), Rg3(10 μmol/L) and Rh2(10 μmol/L)could induce endothelial cell sprouting from the aortic ring(P<0.05). Conclusion SBP, ginsenosideRg3 and Rh2 exhibited significantly pro-angiogenic effect in vitro.
2014, 32(5): 348-351.
doi: 10.3969/j.issn.1006-0111.2014.05.008
Abstract:
Objective To study the stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection. Methods The changes in appearance and pH value of the mixture of the two injections in 0.9% sodium chloride injection within 72 hours at ambient temperature were observed. The concentrations of the two drugs were determined by HPLC. The chromatographic separation was achieved on SinoChrom ODS-BP column, and the mobile phase consisted of acetonitrile:0.05 mol/L potassium dihydrogen phosphate (25:75) at a flow rate of 1.0 ml/min.. Results No significant differences were found in the pH value and appearance of the solution. The contents of tramadol hydrochloride and fentanyl citrate were high than 98% within 72 hours. Conclusion The mixture of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection was stability within 72 hours under room temperature.
Objective To study the stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection. Methods The changes in appearance and pH value of the mixture of the two injections in 0.9% sodium chloride injection within 72 hours at ambient temperature were observed. The concentrations of the two drugs were determined by HPLC. The chromatographic separation was achieved on SinoChrom ODS-BP column, and the mobile phase consisted of acetonitrile:0.05 mol/L potassium dihydrogen phosphate (25:75) at a flow rate of 1.0 ml/min.. Results No significant differences were found in the pH value and appearance of the solution. The contents of tramadol hydrochloride and fentanyl citrate were high than 98% within 72 hours. Conclusion The mixture of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection was stability within 72 hours under room temperature.
2014, 32(5): 352-353,356.
doi: 10.3969/j.issn.1006-0111.2014.05.009
Abstract:
Objective To establish the determination method of the polysaccharide in Verdihong paint. Methods The anhydrous dextrose was used as the control, 0.2% anthrone-sulfuric acid as the stain, the content of polysaccharide was determined by ultraviolet spectrophotometer at the wavelength of 620 nm. Results The polysaccharide curve was linear within a range of 1.9~34.2 μg/ml, linear equation was Y=0.033 X-0.006 7 (r=0.999 9), the average recovery was 98.6% with RSD of 1.06% (n=6). Conclusion This method was convenient, stable and coud be used to assay content of the polysaccharide in Verdihong paint.
Objective To establish the determination method of the polysaccharide in Verdihong paint. Methods The anhydrous dextrose was used as the control, 0.2% anthrone-sulfuric acid as the stain, the content of polysaccharide was determined by ultraviolet spectrophotometer at the wavelength of 620 nm. Results The polysaccharide curve was linear within a range of 1.9~34.2 μg/ml, linear equation was Y=0.033 X-0.006 7 (r=0.999 9), the average recovery was 98.6% with RSD of 1.06% (n=6). Conclusion This method was convenient, stable and coud be used to assay content of the polysaccharide in Verdihong paint.
2014, 32(5): 354-356.
doi: 10.3969/j.issn.1006-0111.2014.05.010
Abstract:
Objective To establish a LC-MS-MS method for determining febuxostate in human plasma. Methods Febuxostate added into blank plasma was sedimented by acetonitrile, and the supernatant was determined by LC-MS-MS. Analytical column was Thermo Biobasic-8, 5 μm, 50 mm×2.1 mm(ID). The mobile phase consisted of acetonitrile-10 mmol/L ammonium acetate (0.05% acid=70:30 at a flow rate of 0.2 ml/min. Mass spectrum conditions:ESI-was performed in the SRM mode using target ions m/z 315→271 (10 eV)(febuxostate), m/z 360→274 (18 eV)(bezafibrate), SP 3 500 kV, SGP 10 Arb, AGP45 Arb, TEM 270℃. Results The calibration curve was linear over the range of 10-8 000 μg/L. The LLOQ of Febuxostate in plasma was 10 μg/L.The extracted recovery was >85%.The intra-and inter-day RSD were <15%. Conclusion The method was sensitive, simple and accurate to determinate febuxostate plasma concentration and to study pharmacokinetics of febuxostate.
Objective To establish a LC-MS-MS method for determining febuxostate in human plasma. Methods Febuxostate added into blank plasma was sedimented by acetonitrile, and the supernatant was determined by LC-MS-MS. Analytical column was Thermo Biobasic-8, 5 μm, 50 mm×2.1 mm(ID). The mobile phase consisted of acetonitrile-10 mmol/L ammonium acetate (0.05% acid=70:30 at a flow rate of 0.2 ml/min. Mass spectrum conditions:ESI-was performed in the SRM mode using target ions m/z 315→271 (10 eV)(febuxostate), m/z 360→274 (18 eV)(bezafibrate), SP 3 500 kV, SGP 10 Arb, AGP45 Arb, TEM 270℃. Results The calibration curve was linear over the range of 10-8 000 μg/L. The LLOQ of Febuxostate in plasma was 10 μg/L.The extracted recovery was >85%.The intra-and inter-day RSD were <15%. Conclusion The method was sensitive, simple and accurate to determinate febuxostate plasma concentration and to study pharmacokinetics of febuxostate.
2014, 32(5): 357-359.
doi: 10.3969/j.issn.1006-0111.2014.05.011
Abstract:
Objective To develop an identification model of raceanisodamine tablets by diffuse reflection near-infrared spectroscopy and pattern recognition. Methods The diffuse reflectance spectra in the 12 000-4 000 cm-1 spectral coverage range of raceanisodamine tablets from eight different pharmaceutical factories were collected to establish the identification model.A mono-component near infrared model was established for raceanisodamine tablets. Results The parameters of the identification model for the raceanisodamine tablets was as follows:spectral range was 5 400-7 000 cm-1, the pretreatment method was first derivative and normalization; the threshold was 0.603. And the model was validated, which met the requirements of application. Conclusion The results showed that identification model for the raceanisodamine tablets by near infrared spectroscopy was feasible, which provided a reference method for the model updating.
Objective To develop an identification model of raceanisodamine tablets by diffuse reflection near-infrared spectroscopy and pattern recognition. Methods The diffuse reflectance spectra in the 12 000-4 000 cm-1 spectral coverage range of raceanisodamine tablets from eight different pharmaceutical factories were collected to establish the identification model.A mono-component near infrared model was established for raceanisodamine tablets. Results The parameters of the identification model for the raceanisodamine tablets was as follows:spectral range was 5 400-7 000 cm-1, the pretreatment method was first derivative and normalization; the threshold was 0.603. And the model was validated, which met the requirements of application. Conclusion The results showed that identification model for the raceanisodamine tablets by near infrared spectroscopy was feasible, which provided a reference method for the model updating.
2014, 32(5): 360-361,388.
doi: 10.3969/j.issn.1006-0111.2014.05.012
Abstract:
Objective To study the effect of Xinnaoning tablets on blood stasis rat model which was caused to dexamethasone sodium phosphate injection with symptom score, K-value of blood, modified index, electrophoresis index. Methods 60 rats, were divided into 6 groups stochastically, and 1 group for vacuity contrast group, the other 5 groups for blood stasis model, the 5 groups were model group, Naoan tablets group, high dose, medium dose and low dose Xinnaoning tablets groups. Symptom score were evaluated, K-value of blood, Modified index, Electrophoresis index were measured. Results The Model was constructed successfully, model group and administrate groups had significant blood symptoms (P<0.01).The effect of high dose Xinnaoning tablets group to blood stasis rat model which was caused to dexamethasone sodium phosphate injection was best. High dose and medium dose Xinnaoning tablets groups could induce K-value significantly (P<0.01). Xinnaoning tablets groups could improve modified index and electrophoresis index significantly (P<0.01), and the effect of high dose and medium dose Xinnaoning tablets groups to blood stasis rat model which was caused to dexamethasone sodium phosphate injection were better. Conclusion Xinnaoning tablets had good improvement effect on blood stasis.
Objective To study the effect of Xinnaoning tablets on blood stasis rat model which was caused to dexamethasone sodium phosphate injection with symptom score, K-value of blood, modified index, electrophoresis index. Methods 60 rats, were divided into 6 groups stochastically, and 1 group for vacuity contrast group, the other 5 groups for blood stasis model, the 5 groups were model group, Naoan tablets group, high dose, medium dose and low dose Xinnaoning tablets groups. Symptom score were evaluated, K-value of blood, Modified index, Electrophoresis index were measured. Results The Model was constructed successfully, model group and administrate groups had significant blood symptoms (P<0.01).The effect of high dose Xinnaoning tablets group to blood stasis rat model which was caused to dexamethasone sodium phosphate injection was best. High dose and medium dose Xinnaoning tablets groups could induce K-value significantly (P<0.01). Xinnaoning tablets groups could improve modified index and electrophoresis index significantly (P<0.01), and the effect of high dose and medium dose Xinnaoning tablets groups to blood stasis rat model which was caused to dexamethasone sodium phosphate injection were better. Conclusion Xinnaoning tablets had good improvement effect on blood stasis.
2014, 32(5): 362-365,373.
doi: 10.3969/j.issn.1006-0111.2014.05.013
Abstract:
Objective To synthesize miRNA carrier PEG-b-PLL and to testify the stability, encapsulation efficiency and cytotoxicity of its complexes. Methods H1NMR was used to determine the degree of polymerization of PLL, 4% agarose gel electrophoresis was used to determine entrapment of the polyer to the miRNA; then dynamic light scattering(DLS) was used to measure the hydrodynamic parameter such as size, polydispersity index(PDI) and zeta potential of the polyplexes. The entrapment efficiency was determined by ultraviolet-visible spectrophotometer, and finally, the cyto-toxicity of PEG-b-PLL was evaluated by CKK-8 kit with K562 cell lines. Results The characteristics indicated polyplexes prepared by PEG-b-PLL and miRNA fulfill the demand of being the gene carrier of miRNA because of low cyto-toxicity, high encapsulation efficiency and stability. Conclusion The miRNA carrier PEG-b-PLL had good character and low cyto-toxicity. It showed considerable potential as an efficient miRNA carrier.
Objective To synthesize miRNA carrier PEG-b-PLL and to testify the stability, encapsulation efficiency and cytotoxicity of its complexes. Methods H1NMR was used to determine the degree of polymerization of PLL, 4% agarose gel electrophoresis was used to determine entrapment of the polyer to the miRNA; then dynamic light scattering(DLS) was used to measure the hydrodynamic parameter such as size, polydispersity index(PDI) and zeta potential of the polyplexes. The entrapment efficiency was determined by ultraviolet-visible spectrophotometer, and finally, the cyto-toxicity of PEG-b-PLL was evaluated by CKK-8 kit with K562 cell lines. Results The characteristics indicated polyplexes prepared by PEG-b-PLL and miRNA fulfill the demand of being the gene carrier of miRNA because of low cyto-toxicity, high encapsulation efficiency and stability. Conclusion The miRNA carrier PEG-b-PLL had good character and low cyto-toxicity. It showed considerable potential as an efficient miRNA carrier.
2014, 32(5): 366-367,382.
doi: 10.3969/j.issn.1006-0111.2014.05.014
Abstract:
Objective To establish a method for microbial limit test of fast vertical liquid hand disinfectant gel. Methods The membrane filtration method, in accordance with the Chinese Pharmacopoeia 2010 Edition (part two) relevant requirements of microbial limit test method for validation of microbial limit test for fast vertical liquid hand disinfectant gel. Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Candida a lbicans, Aspergillus niger were taken as test bacteria, Pseudomonas aeruginosa and Staphylococcus aureus were taken as control bacteria. Verification test was carried out in parallel test for 3 independent, recoveries and every trail rate were calculated. Results In bacteria, molds and yeasts count method validation test, recovery test strain rate, the control bacteria test results met the requirements. Conclusion The membrane filtration method was feasible and effective, which could be used for microbial limit test of fast vertical liquid hand disinfectant gel.
Objective To establish a method for microbial limit test of fast vertical liquid hand disinfectant gel. Methods The membrane filtration method, in accordance with the Chinese Pharmacopoeia 2010 Edition (part two) relevant requirements of microbial limit test method for validation of microbial limit test for fast vertical liquid hand disinfectant gel. Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Candida a lbicans, Aspergillus niger were taken as test bacteria, Pseudomonas aeruginosa and Staphylococcus aureus were taken as control bacteria. Verification test was carried out in parallel test for 3 independent, recoveries and every trail rate were calculated. Results In bacteria, molds and yeasts count method validation test, recovery test strain rate, the control bacteria test results met the requirements. Conclusion The membrane filtration method was feasible and effective, which could be used for microbial limit test of fast vertical liquid hand disinfectant gel.
2014, 32(5): 368-371.
doi: 10.3969/j.issn.1006-0111.2014.05.015
Abstract:
Objective To establish a microbial limit examination method and a verified methodology for diluted benzalkonium bromide solution, and ensure the effectiveness of the method. Methods Microbial limit test of diluted benzalkonium bromide solution was used as the validation methodology according to the validation test requirements of appendix XI J of the second version of the "Chinese Pharmacopoeia" published in 2010. Results Membrane filtration method could be used for counting bacteria, mold and yeast count in the microbial limit examination of the diluted benzalkonium bromide solution; membrane filtration method could be adopted to control the bacteria. Conclusion Antibacterial activity of diluted benzalkonium bromide solution should be fully considered before examination when building its examination method through microbial limit methodology validation.
Objective To establish a microbial limit examination method and a verified methodology for diluted benzalkonium bromide solution, and ensure the effectiveness of the method. Methods Microbial limit test of diluted benzalkonium bromide solution was used as the validation methodology according to the validation test requirements of appendix XI J of the second version of the "Chinese Pharmacopoeia" published in 2010. Results Membrane filtration method could be used for counting bacteria, mold and yeast count in the microbial limit examination of the diluted benzalkonium bromide solution; membrane filtration method could be adopted to control the bacteria. Conclusion Antibacterial activity of diluted benzalkonium bromide solution should be fully considered before examination when building its examination method through microbial limit methodology validation.
2014, 32(5): 372-373.
doi: 10.3969/j.issn.1006-0111.2014.05.016
Abstract:
Objective To observe levocarnitine in prevention and treatment of peripheral nerve toxicity caused by paclitaxel. Methods 64 cancer patients treated with paclitaxel-based chemotherapy were randomly divided into two groups, the preventive treatment group and control group.The patients in the preventive treatment group were treated with paclitaxel chemotherapy and levocarnitine.The patients in the control group were treated with the same chemotherapy but without levocarnitine.The incidence rate of neurotoxicity between two groups were compared. Results The incidence rate of neurotoxicity in the preventive treatment group was lower than that of the control group(P<0.05). Conclusion Application of levocarnitine in paclitaxel-based chemotherapy could reduce the neurotoxicity caused by chemotherapy.
Objective To observe levocarnitine in prevention and treatment of peripheral nerve toxicity caused by paclitaxel. Methods 64 cancer patients treated with paclitaxel-based chemotherapy were randomly divided into two groups, the preventive treatment group and control group.The patients in the preventive treatment group were treated with paclitaxel chemotherapy and levocarnitine.The patients in the control group were treated with the same chemotherapy but without levocarnitine.The incidence rate of neurotoxicity between two groups were compared. Results The incidence rate of neurotoxicity in the preventive treatment group was lower than that of the control group(P<0.05). Conclusion Application of levocarnitine in paclitaxel-based chemotherapy could reduce the neurotoxicity caused by chemotherapy.
2014, 32(5): 374-375,399.
doi: 10.3969/j.issn.1006-0111.2014.05.017
Abstract:
Objective To investigate the clinical status about the utility of compound amino acid(15) and dipeptides(2) injection, and to promote the rational drug use in our hospital. Methods Data from 127 patients who used compound amino acid(15) and dipeptides(2) injection in surgical wards were collected in July 2012.The data about the drug usage method, duration, administrated timing, drug combination and the differences in all departments was analyzed. Results Existing problems:62.2% patients used compound amino acid (15) and dipeptides (2) injection by peripheral intravenous infusion, 6.3% patients used more than 14 days and 7.1% patients infused singly. Conclusion Compound amino acid(15) and dipeptides(2) injection had problems of off-label drug use in surgical ward, which need to be improved.
Objective To investigate the clinical status about the utility of compound amino acid(15) and dipeptides(2) injection, and to promote the rational drug use in our hospital. Methods Data from 127 patients who used compound amino acid(15) and dipeptides(2) injection in surgical wards were collected in July 2012.The data about the drug usage method, duration, administrated timing, drug combination and the differences in all departments was analyzed. Results Existing problems:62.2% patients used compound amino acid (15) and dipeptides (2) injection by peripheral intravenous infusion, 6.3% patients used more than 14 days and 7.1% patients infused singly. Conclusion Compound amino acid(15) and dipeptides(2) injection had problems of off-label drug use in surgical ward, which need to be improved.
2014, 32(5): 376-378.
doi: 10.3969/j.issn.1006-0111.2014.05.018
Abstract:
Objective To compare the efficacy and safety of the treatment of panic disorder by electro-acupuncture(EA) and paroxetine. Methods 59 patients were randomly divided into paroxetine group (30 cases) and EA group (29 cases), the therapeutic course was 4 weeks. SAS, HAMA, CGI-EI, BI scale were given to evaluate the efficacy and adverse reactions at 1, 2, 4 weekend before treatment and after treatment. Results EA group total effective rate was 86.66%, the paroxetine group total effective rate was 82.76%, the two groups total efficacy difference was not statistically significant; efficacy index and onset time between the two groups had significant differences. Conclusion The overall curative effects were similar in patients of the two groups, but onset short electro-acupuncture, the curative effect was high and adverse reactions were fewer.
Objective To compare the efficacy and safety of the treatment of panic disorder by electro-acupuncture(EA) and paroxetine. Methods 59 patients were randomly divided into paroxetine group (30 cases) and EA group (29 cases), the therapeutic course was 4 weeks. SAS, HAMA, CGI-EI, BI scale were given to evaluate the efficacy and adverse reactions at 1, 2, 4 weekend before treatment and after treatment. Results EA group total effective rate was 86.66%, the paroxetine group total effective rate was 82.76%, the two groups total efficacy difference was not statistically significant; efficacy index and onset time between the two groups had significant differences. Conclusion The overall curative effects were similar in patients of the two groups, but onset short electro-acupuncture, the curative effect was high and adverse reactions were fewer.
2014, 32(5): 379-382.
doi: 10.3969/j.issn.1006-0111.2014.05.019
Abstract:
Objective Through the analysis of the 5.12 earthquake relief soldiers medication, to provide a reference for future emergency treatment relief workers. Methods May 18, 2008 to August 19, the officers and men of our hospital free treatment for earthquake relief prescription 161 analysis. Results The skin diseases and accessories were the most reported situations and it's up to a total of 47 prescriptions (accounting for 29.19%), diagnosis of insect bite dermatitis and acute bronchitis prescription, 11 and 9, respectively, constitute more than 6.83% and 5.59%. The first factor is the environment in emergency rescue personnel. Conclusion during the emergency relief process, rescue workers targeted prevention is very important.
Objective Through the analysis of the 5.12 earthquake relief soldiers medication, to provide a reference for future emergency treatment relief workers. Methods May 18, 2008 to August 19, the officers and men of our hospital free treatment for earthquake relief prescription 161 analysis. Results The skin diseases and accessories were the most reported situations and it's up to a total of 47 prescriptions (accounting for 29.19%), diagnosis of insect bite dermatitis and acute bronchitis prescription, 11 and 9, respectively, constitute more than 6.83% and 5.59%. The first factor is the environment in emergency rescue personnel. Conclusion during the emergency relief process, rescue workers targeted prevention is very important.
2014, 32(5): 383-385.
doi: 10.3969/j.issn.1006-0111.2014.05.020
Abstract:
Clinical pharmaceutical care for patients with postoperative infection had been carrying out by clinical pharmacy group and a suit of normalized pharmacy consultation on postoperative infection was summarized by using standardized consultation process and consultation method in our hospital for eight years. Postoperative infection, especially the serious infection, only through the normalized pharmacy consultation procedure, including standardized management or standardized service processes, the main contradiction and formulate feasible countermeasure could be quickly grasped, infection could be controlled in time, medication errors could be reduced even be eliminated.
Clinical pharmaceutical care for patients with postoperative infection had been carrying out by clinical pharmacy group and a suit of normalized pharmacy consultation on postoperative infection was summarized by using standardized consultation process and consultation method in our hospital for eight years. Postoperative infection, especially the serious infection, only through the normalized pharmacy consultation procedure, including standardized management or standardized service processes, the main contradiction and formulate feasible countermeasure could be quickly grasped, infection could be controlled in time, medication errors could be reduced even be eliminated.
2014, 32(5): 386-388.
doi: 10.3969/j.issn.1006-0111.2014.05.021
Abstract:
Objective To Improve inpatient safety of oral drugs, and reduce risk of medication errors. Methods 1 696 oral-order errors caused by prescription and transcription from July to December 2012 were investigated by Excel. Results 979 cases (57.7%) reduced the efficiency of unit-dose automated dispensing machines and 717 cases (42.3%) affected to inpatients' medication safety. Conclusion It is very important that pharmacists should check drugs packaged unit-dose with prescription paper. It is also an effect means to prevent medication errors that continuing training pharmacists'skill, intensifying communication with clinics and strengthening information technology systems.
Objective To Improve inpatient safety of oral drugs, and reduce risk of medication errors. Methods 1 696 oral-order errors caused by prescription and transcription from July to December 2012 were investigated by Excel. Results 979 cases (57.7%) reduced the efficiency of unit-dose automated dispensing machines and 717 cases (42.3%) affected to inpatients' medication safety. Conclusion It is very important that pharmacists should check drugs packaged unit-dose with prescription paper. It is also an effect means to prevent medication errors that continuing training pharmacists'skill, intensifying communication with clinics and strengthening information technology systems.
2014, 32(5): 389-392.
doi: 10.3969/j.issn.1006-0111.2014.05.022
Abstract:
Objective To investigate better patient care via the improved use of medicines and pharmaceutical services for hospital inpatients. Methods Through a case of invasive pulmonary aspergillosis in a diabetic patient, the efficacy of prescribed treatment was evaluated, and adverse drug reactions were prevented by clinical pharmacists. Results Pharmaceutical services were provided, adverse drug reactions were reduced and the use of medicines was improved by clinical pharmacists. Conclusion Clinical pharmacists could help provide tailored treatment to the needs of individuals, ensure patient safety and appropriate use of medicines.
Objective To investigate better patient care via the improved use of medicines and pharmaceutical services for hospital inpatients. Methods Through a case of invasive pulmonary aspergillosis in a diabetic patient, the efficacy of prescribed treatment was evaluated, and adverse drug reactions were prevented by clinical pharmacists. Results Pharmaceutical services were provided, adverse drug reactions were reduced and the use of medicines was improved by clinical pharmacists. Conclusion Clinical pharmacists could help provide tailored treatment to the needs of individuals, ensure patient safety and appropriate use of medicines.
2014, 32(5): 393-395.
doi: 10.3969/j.issn.1006-0111.2014.05.023
Abstract:
Objective To reform practice in the pharmacy administration courses for cultivating student's comprehensive quality. Method Reform practice was tried in the aspects of teaching methods, teaching contents, teaching means and evaluations based on theoretical teaching in the pharmacy administration courses. Results A teaching system was formed to enhance pharmacy undergraduate's comprehensive abilities, including self-learning ability, language skills, communication and social skills, information processing skills, solving problem skills and ability to cooperate with others. Conclusion It is a workable and valuable teaching system which should be improved and innovated and kept up with the times in future.
Objective To reform practice in the pharmacy administration courses for cultivating student's comprehensive quality. Method Reform practice was tried in the aspects of teaching methods, teaching contents, teaching means and evaluations based on theoretical teaching in the pharmacy administration courses. Results A teaching system was formed to enhance pharmacy undergraduate's comprehensive abilities, including self-learning ability, language skills, communication and social skills, information processing skills, solving problem skills and ability to cooperate with others. Conclusion It is a workable and valuable teaching system which should be improved and innovated and kept up with the times in future.
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