Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel

YAN Jianwei

doi:10.3969/j.issn.1006-0111.2014.05.016

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Objective To observe levocarnitine in prevention and treatment of peripheral nerve toxicity caused by paclitaxel. Methods 64 cancer patients treated with paclitaxel-based chemotherapy were randomly divided into two groups, the preventive treatment group and control group.The patients in the preventive treatment group were treated with paclitaxel chemotherapy and levocarnitine.The patients in the control group were treated with the same chemotherapy but without levocarnitine.The incidence rate of neurotoxicity between two groups were compared. Results The incidence rate of neurotoxicity in the preventive treatment group was lower than that of the control group(P<0.05). Conclusion Application of levocarnitine in paclitaxel-based chemotherapy could reduce the neurotoxicity caused by chemotherapy.

Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel

Department of Medicine, Yuyao People's Hospital, Yuyao 315400, China

Received Date: 2013-04-01

Rev Recd Date: 2013-07-30

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Abstract: Objective To observe levocarnitine in prevention and treatment of peripheral nerve toxicity caused by paclitaxel. Methods 64 cancer patients treated with paclitaxel-based chemotherapy were randomly divided into two groups, the preventive treatment group and control group.The patients in the preventive treatment group were treated with paclitaxel chemotherapy and levocarnitine.The patients in the control group were treated with the same chemotherapy but without levocarnitine.The incidence rate of neurotoxicity between two groups were compared. Results The incidence rate of neurotoxicity in the preventive treatment group was lower than that of the control group(P<0.05). Conclusion Application of levocarnitine in paclitaxel-based chemotherapy could reduce the neurotoxicity caused by chemotherapy.

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Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel

doi: 10.3969/j.issn.1006-0111.2014.05.016

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通讯作者: 陈斌, [email protected]

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