Lox-1, a new target in cardiovascular disease

LI Qian; RUI Yaocheng

doi:10.3969/j.issn.1006-0111.2014.05.001

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Volume 32 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2014 > 32(5): 321-323

LI Qian, RUI Yaocheng. Lox-1, a new target in cardiovascular disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001

Citation:

LI Qian, RUI Yaocheng. Lox-1, a new target in cardiovascular disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001

Lox-1, a new target in cardiovascular disease

doi: 10.3969/j.issn.1006-0111.2014.05.001

Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-02-27
Rev Recd Date: 2013-10-23

Abstract

Objective Lox-1 (lectin-like oxidized low-density lipoprotein receptor-1) was one of the main receptor of ox-LDL, which took an important role in vascular endothelial dysfunction, the formation of foam cells, and the stability of atherosclerotic plaques. To investigate the role of Lox-1 in cardiovascular diseases. Methods The literatures of Lox-1 in cardiovascular diseases retrospectively were reviewed. Results As a new ox-LDL scavenger receptor, Lox-1 played an important role in cardiovascular diseases. Conclusion Lox-1 might provide new ideas for cardiovascular diseases.
- lectin-like oxidized low-density-lipoprotein receptor-1,
- atherosclerosis,
- oxidized low-density lipoprotein

References

[1]	Sawamura T, Kume N, Aoyama T, et al. An endothelial receptor for oxidized low-density lipoprotein[J]. Nature, 1997, 386:73-77.
[2]	Mehta JL, Li DY. Identification and autoregulation of receptor for ox-LDL in cultured human coronary artery endothelial cells[J]. Biochem Biophys Res Commun, 1998, 248:511-514.
[3]	Chen M, Kakutani M, Naruko T,et al. Activation-dependent surface expression of lox-1 in human platelets[J]. Biochem Biophys Res Commun, 2001, 282(1):153-158.
[4]	Chen XP, Du GH. Lectin like oxidized low-density lipoprotein receptor-1:protein, ligands, expression and pathophysiological significance[J]. Chin Med J, 2007, 120(5):421-626.
[5]	Peiser L, Mukhopadhyay S, Gordon S. Scavenger receptors in innate immunity[J]. Curr Opin Immunol, 2002, 14:123-128.
[6]	Nickel T, Schmauss D, Hanssen H, et al. oxLDL uptake by dendritic cells induces upregulation of scavenger-receptors, maturation and differentiation[J]. Atherosclerosis, 2009, 205(2):442-450.
[7]	Chen XP, Zhang TT, Du GH. Lectin-like oxidized low-density Lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis[J]. Cardiovas Drug Rev, 2007, 25(2):146-161.
[8]	Mehta JL, Sanada N, Hu CP, et al. Deletion of olr1 reduces atherogenesis in ldlr knockout mice fed high cholesterol diet[J]. Circ Res, 2007, 100:1634-1642.
[9]	Sona M, Tanu G, Jawahar L,et al. Oxidized ldl, lox-1 and atherosclerosis[J]. Cardiovasc Drugs Ther, 2011, 25(5):419-429.
[10]	Hirokazu M, Noriaki K, Kazutaka H, et al. Interleukin 18 stimulates release of soluble lectin-like oxidized ldl receptor-1 (slox-1)[J]. Atherosclerosis,2009, 202:176-182.
[11]	Magomed Khaidakov, Sona Mitra, Xianwei Wang, et al. Oxidized ldl receptor 1 (olr1) as a possible link between obesity,dyslipidemia and cancer[J]. Plos One, 2011, 6(5):e20277.
[12]	Xu SW, Ogura S, Chen JW, et al. Lox-1 in atherosclerosis:biological functions and pharmacological modifiers[J]. Cell Mol Life Sci, 2013, 70(6):2859-2872.
[13]	Matarazzo S, Quitadamo MC, Mango R, et al. Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption[J]. Mol Pharmacol, 2012, 82(2):246-254.
[14]	Mehta JL, Chen J, Yu F, et al. Aspirin inhibits ox-LDL mediated Lox-1 expression and metalloproteinase-1 in human coronary endothelial cells[J]. Cardiovasc Res, 2004, 64(2):243-249.
[15]	Chen JW, Zhou SB, Tan ZM. Aspirin and pravastatin reduce lectin-like oxidized low density lipoprotein receptor-1 expression, adhesion molecules and oxidative stress in human coronary artery endothelial cells[J]. Chin Med J, 2010, 123(12):1553-1556.
[16]	Pang T, Wang J, Benicky J, et al. Minocycline ameliorates lps-induced inflammation in human monocytes by novel mechanisms including Lox-1,nur77 and litaf inhibition[J]. Biochim Biophys Acta, 2012, 1820(4):503-510.
[17]	Li L, Renier G. The oral anti-diabetic agent, gliclazide, inhibits oxidized ldl-mediated lox-1 expression, metalloproteinase-9 secretion and apoptosis in human aortic endothelial cells[J]. Atherosclerosis, 2009, 204(1):40-46.
[18]	Xu S, Liu Z, Huang Y, et al. Tanshinone Ⅱ-A inhibits oxidized LDL induced Lox-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation[J]. Transl Res, 2012, 160(2):114-124.
[19]	Kang BY, Khan JA, Ryu S, et al. Curcumin reduces angiotensin Ⅱ-mediated cardiomyocyte growth via Lox-1 inhibition[J]. J Cardiovasc Pharmacol, 2010, 55(2):176-183.
[20]	Guan S, Wang B, Li W, et al. Effects of berberine on expression of Lox-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL[J]. Am J Chin Med, 2010, 38(6):1161-1169.
[21]	Lee WJ,Ou HC, Chou MM, et al. Ellagic acid inhibits oxidized LDL-mediated Lox-1 expression, ROS generation, and inflammation in human endothelial cells[J]. J Vasc Surg, 2010, 52(5):1290-1300.
[22]	Ou HC, Song TY, Yeh YC, et al. EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting Lox-1-mediated signaling[J]. J Appl Physiol, 2010, 108(6):1745-1756.
[23]	Chang HC, Chen TG, Tai YT, et al. Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells[J]. J Cereb Blood Flow Metab, 2011, 31(3):842-854.
[24]	Taye A, Saad AH, Kumar AH, et al. Effect of apocynin on NADPH oxidase-mediated oxidative stress-Lox-1-eNOS pathway in human endothelial cells exposed to high glucose[J]. Eur J Pharmacol, 2010, 627(1-3):42-48.
[25]	Lee MJ, Lee HS, Park SD, et al. Leonurus sibiricus herb extract suppresses oxidative stress and ameliorates hypercholesterolemia in C57BL/6 mice and TNF-alpha induced expression of adhesion molecules and lectin-like oxidized LDL receptor-1 in human umbilical vein endothelial cells[J]. Biosci Biotechnol Biochem, 2010, 74(2):279-284.
[26]	Shibata Y, Kume N, Arai H, et al. Mulberry leaf aqueous fractions inhibit TNF-alpha-induced nuclear factor kappaB (NF-kappaB) activation and lectin-like oxidized LDL receptor-1(Lox-1) expression in vascular endothelial cells[J]. Atherosclerosis, 2007, 193(1):20-27.

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通讯作者: 陈斌, [email protected]

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沈阳化工大学材料科学与工程学院沈阳 110142

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Lox-1, a new target in cardiovascular disease

Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-02-27

Rev Recd Date: 2013-10-23

Key words:

lectin-like oxidized low-density-lipoprotein receptor-1 /
atherosclerosis /
oxidized low-density lipoprotein

Abstract: Objective Lox-1 (lectin-like oxidized low-density lipoprotein receptor-1) was one of the main receptor of ox-LDL, which took an important role in vascular endothelial dysfunction, the formation of foam cells, and the stability of atherosclerotic plaques. To investigate the role of Lox-1 in cardiovascular diseases. Methods The literatures of Lox-1 in cardiovascular diseases retrospectively were reviewed. Results As a new ox-LDL scavenger receptor, Lox-1 played an important role in cardiovascular diseases. Conclusion Lox-1 might provide new ideas for cardiovascular diseases.

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Reference (26)

[1]	Sawamura T, Kume N, Aoyama T, et al. An endothelial receptor for oxidized low-density lipoprotein[J]. Nature, 1997, 386:73-77.
[2]	Mehta JL, Li DY. Identification and autoregulation of receptor for ox-LDL in cultured human coronary artery endothelial cells[J]. Biochem Biophys Res Commun, 1998, 248:511-514.
[3]	Chen M, Kakutani M, Naruko T,et al. Activation-dependent surface expression of lox-1 in human platelets[J]. Biochem Biophys Res Commun, 2001, 282(1):153-158.
[4]	Chen XP, Du GH. Lectin like oxidized low-density lipoprotein receptor-1:protein, ligands, expression and pathophysiological significance[J]. Chin Med J, 2007, 120(5):421-626.
[5]	Peiser L, Mukhopadhyay S, Gordon S. Scavenger receptors in innate immunity[J]. Curr Opin Immunol, 2002, 14:123-128.
[6]	Nickel T, Schmauss D, Hanssen H, et al. oxLDL uptake by dendritic cells induces upregulation of scavenger-receptors, maturation and differentiation[J]. Atherosclerosis, 2009, 205(2):442-450.
[7]	Chen XP, Zhang TT, Du GH. Lectin-like oxidized low-density Lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis[J]. Cardiovas Drug Rev, 2007, 25(2):146-161.
[8]	Mehta JL, Sanada N, Hu CP, et al. Deletion of olr1 reduces atherogenesis in ldlr knockout mice fed high cholesterol diet[J]. Circ Res, 2007, 100:1634-1642.
[9]	Sona M, Tanu G, Jawahar L,et al. Oxidized ldl, lox-1 and atherosclerosis[J]. Cardiovasc Drugs Ther, 2011, 25(5):419-429.
[10]	Hirokazu M, Noriaki K, Kazutaka H, et al. Interleukin 18 stimulates release of soluble lectin-like oxidized ldl receptor-1 (slox-1)[J]. Atherosclerosis,2009, 202:176-182.
[11]	Magomed Khaidakov, Sona Mitra, Xianwei Wang, et al. Oxidized ldl receptor 1 (olr1) as a possible link between obesity,dyslipidemia and cancer[J]. Plos One, 2011, 6(5):e20277.
[12]	Xu SW, Ogura S, Chen JW, et al. Lox-1 in atherosclerosis:biological functions and pharmacological modifiers[J]. Cell Mol Life Sci, 2013, 70(6):2859-2872.
[13]	Matarazzo S, Quitadamo MC, Mango R, et al. Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption[J]. Mol Pharmacol, 2012, 82(2):246-254.
[14]	Mehta JL, Chen J, Yu F, et al. Aspirin inhibits ox-LDL mediated Lox-1 expression and metalloproteinase-1 in human coronary endothelial cells[J]. Cardiovasc Res, 2004, 64(2):243-249.
[15]	Chen JW, Zhou SB, Tan ZM. Aspirin and pravastatin reduce lectin-like oxidized low density lipoprotein receptor-1 expression, adhesion molecules and oxidative stress in human coronary artery endothelial cells[J]. Chin Med J, 2010, 123(12):1553-1556.
[16]	Pang T, Wang J, Benicky J, et al. Minocycline ameliorates lps-induced inflammation in human monocytes by novel mechanisms including Lox-1,nur77 and litaf inhibition[J]. Biochim Biophys Acta, 2012, 1820(4):503-510.
[17]	Li L, Renier G. The oral anti-diabetic agent, gliclazide, inhibits oxidized ldl-mediated lox-1 expression, metalloproteinase-9 secretion and apoptosis in human aortic endothelial cells[J]. Atherosclerosis, 2009, 204(1):40-46.
[18]	Xu S, Liu Z, Huang Y, et al. Tanshinone Ⅱ-A inhibits oxidized LDL induced Lox-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation[J]. Transl Res, 2012, 160(2):114-124.
[19]	Kang BY, Khan JA, Ryu S, et al. Curcumin reduces angiotensin Ⅱ-mediated cardiomyocyte growth via Lox-1 inhibition[J]. J Cardiovasc Pharmacol, 2010, 55(2):176-183.
[20]	Guan S, Wang B, Li W, et al. Effects of berberine on expression of Lox-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL[J]. Am J Chin Med, 2010, 38(6):1161-1169.
[21]	Lee WJ,Ou HC, Chou MM, et al. Ellagic acid inhibits oxidized LDL-mediated Lox-1 expression, ROS generation, and inflammation in human endothelial cells[J]. J Vasc Surg, 2010, 52(5):1290-1300.
[22]	Ou HC, Song TY, Yeh YC, et al. EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting Lox-1-mediated signaling[J]. J Appl Physiol, 2010, 108(6):1745-1756.
[23]	Chang HC, Chen TG, Tai YT, et al. Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells[J]. J Cereb Blood Flow Metab, 2011, 31(3):842-854.
[24]	Taye A, Saad AH, Kumar AH, et al. Effect of apocynin on NADPH oxidase-mediated oxidative stress-Lox-1-eNOS pathway in human endothelial cells exposed to high glucose[J]. Eur J Pharmacol, 2010, 627(1-3):42-48.
[25]	Lee MJ, Lee HS, Park SD, et al. Leonurus sibiricus herb extract suppresses oxidative stress and ameliorates hypercholesterolemia in C57BL/6 mice and TNF-alpha induced expression of adhesion molecules and lectin-like oxidized LDL receptor-1 in human umbilical vein endothelial cells[J]. Biosci Biotechnol Biochem, 2010, 74(2):279-284.
[26]	Shibata Y, Kume N, Arai H, et al. Mulberry leaf aqueous fractions inhibit TNF-alpha-induced nuclear factor kappaB (NF-kappaB) activation and lectin-like oxidized LDL receptor-1(Lox-1) expression in vascular endothelial cells[J]. Atherosclerosis, 2007, 193(1):20-27.

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Lox-1, a new target in cardiovascular disease

doi: 10.3969/j.issn.1006-0111.2014.05.001

Abstract

References

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通讯作者: 陈斌, [email protected]

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