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Volume 33 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(1): 63-64,93

LIN Xiaoming, WEI Baohan, ZENG Yi, WEI Pingyuan, LIANG Hanqin, XIE Weiqian, CHEN Mingzhong. Stability of sodium nitroprusside for injection in two different dissolvants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 63-64,93. doi: 10.3969/j.issn.1006-0111.2015.01.017
Citation: LIN Xiaoming, WEI Baohan, ZENG Yi, WEI Pingyuan, LIANG Hanqin, XIE Weiqian, CHEN Mingzhong. Stability of sodium nitroprusside for injection in two different dissolvants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 63-64,93. doi: 10.3969/j.issn.1006-0111.2015.01.017
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Stability of sodium nitroprusside for injection in two different dissolvants

doi: 10.3969/j.issn.1006-0111.2015.01.017

  • People's Hospital of Guigang City, Guigang 537100, China

  • Received Date: 2013-11-09
  • Rev Recd Date: 2014-03-05
  • Objective To study the stability of sodium nitroprusside for injection in 5% glucose injection and 0.9% sodium chloride injection,and provide reference for clinical rational drug use. Methods The content of sodium nitroprusside for injection in different dissolvants(5% glueose,sodium chloride injection) within 26 h was determined by HPLC.The change of micro particle was measured by light blockage method in accordance with China pharmacopeia(2010 edition),and the appearance and UV visible absorption spectroscopy and pH, the osmotic pressure of the mixtures were observed as well. Results The changes in appearnace,UV visible absorption spectroscopy,pH value,content and microparticle were not significant. Conclusion Sodium nitroprusside for injection were stable within 26 h after mixing with different dissolvants (5%glueose,sodium chloride injection).
  • [1] 林小明,韦宝含,曾 毅,等.HPLC法测定硝普钠氯化钠注射液中硝普钠的含量[J].北方药学,2013,10(12):11-12.
    [2] 林小明,韦宝含,曾 毅,等.HPLC法测定硝普钠葡萄糖注射液中硝普钠的含量[J].临床合理用药杂志,2014,7(8):84-85.
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Stability of sodium nitroprusside for injection in two different dissolvants

doi: 10.3969/j.issn.1006-0111.2015.01.017
  • People's Hospital of Guigang City, Guigang 537100, China
  • Received Date: 2013-11-09
  • Rev Recd Date: 2014-03-05

Abstract: Objective To study the stability of sodium nitroprusside for injection in 5% glucose injection and 0.9% sodium chloride injection,and provide reference for clinical rational drug use. Methods The content of sodium nitroprusside for injection in different dissolvants(5% glueose,sodium chloride injection) within 26 h was determined by HPLC.The change of micro particle was measured by light blockage method in accordance with China pharmacopeia(2010 edition),and the appearance and UV visible absorption spectroscopy and pH, the osmotic pressure of the mixtures were observed as well. Results The changes in appearnace,UV visible absorption spectroscopy,pH value,content and microparticle were not significant. Conclusion Sodium nitroprusside for injection were stable within 26 h after mixing with different dissolvants (5%glueose,sodium chloride injection).

LIN Xiaoming, WEI Baohan, ZENG Yi, WEI Pingyuan, LIANG Hanqin, XIE Weiqian, CHEN Mingzhong. Stability of sodium nitroprusside for injection in two different dissolvants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 63-64,93. doi: 10.3969/j.issn.1006-0111.2015.01.017
Citation: LIN Xiaoming, WEI Baohan, ZENG Yi, WEI Pingyuan, LIANG Hanqin, XIE Weiqian, CHEN Mingzhong. Stability of sodium nitroprusside for injection in two different dissolvants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 63-64,93. doi: 10.3969/j.issn.1006-0111.2015.01.017
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