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WANG Fangfang. Optimization of preparation formulation of ethacridine solution by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 49-50,64. doi: 10.3969/j.issn.1006-0111.2014.01.012
Citation: WANG Fangfang. Optimization of preparation formulation of ethacridine solution by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 49-50,64. doi: 10.3969/j.issn.1006-0111.2014.01.012

Optimization of preparation formulation of ethacridine solution by orthogonal design

doi: 10.3969/j.issn.1006-0111.2014.01.012
  • Received Date: 2013-01-29
  • Rev Recd Date: 2013-09-02
  • Objective To compare the stability of ethacridine solution influenced by three factors:pH value, antioxidants and inert gas, to find out the most economical and effective production of ethacridine solution for the hospital with the consideration of economic benefits. Methods The content of ethacridine solution was determined by UV spectrophotometry, and the room-temperature storage period was predicted with the initial uniform rate method. Finally, the optimal conditions for producing the ethacridine solution was selected by orthogonal design. Results Ethacridine solution was the most stable under the condition of pH4.0, 0.10% p-phenetidine and nitrogen of 2 minutes. Ethacridine solution was the second most stable under the condition of pH4.5, 0.00% p-phenetidine and nitrogen of 2 minutes. Conclusion The condition of pH4.5 and nitrogen of 2 minutes was the optimal choice by considering the irritation of ethacridine solution, the cost of production and operation difficulty. However, more tests should be done to find out the optimal plan of production.
  • [1] 白瑞芝.利凡诺在外科换药中的应用[J].临床合理用药,2009,2(9):13.
    [2] 中华人民共和国卫生部药政局.中国医院制剂规范[M].2版.北京:中国医药科技出版社,1995:23-24.
    [3] 胡晓波,饶丹.依沙吖啶溶液处方中加入硫代硫酸钠的合理性的考察[J].贵州医药,2007,31(8):736.
    [4] Pambor MA. p-phenetidine containing antioxidant as an occupational eczematogenic agent in the manufacturing of special feed mixtures[J].Berufsdermatosen,1971,19(6):285-291.
    [5] 任飞宇,赵常青.利凡诺溶液的稳定性考察[J].西北药学杂志,2009,24(6):485-486.
    [6] 王劲,杨天燕,张靖贤.不同水质对依沙吖啶溶液稳定性的影响[J].医药导报,2003,22(9):642.
    [7] 张又才,程义琳.依沙吖啶溶液稳定性考察[J].中国药师,2003,6(2):88.
    [8] 黄之训,张惠芳.不同载体及配方的乳酸依沙吖啶溶液稳定性考察[J].中国医院药学杂志,2006,26(8):1023-1024.
    [9] 颜宏生,杨艺华.乳酸依沙吖啶溶液沉淀原因探讨[J].临床合理用药,2009,2(13):112.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Optimization of preparation formulation of ethacridine solution by orthogonal design

doi: 10.3969/j.issn.1006-0111.2014.01.012

Abstract: Objective To compare the stability of ethacridine solution influenced by three factors:pH value, antioxidants and inert gas, to find out the most economical and effective production of ethacridine solution for the hospital with the consideration of economic benefits. Methods The content of ethacridine solution was determined by UV spectrophotometry, and the room-temperature storage period was predicted with the initial uniform rate method. Finally, the optimal conditions for producing the ethacridine solution was selected by orthogonal design. Results Ethacridine solution was the most stable under the condition of pH4.0, 0.10% p-phenetidine and nitrogen of 2 minutes. Ethacridine solution was the second most stable under the condition of pH4.5, 0.00% p-phenetidine and nitrogen of 2 minutes. Conclusion The condition of pH4.5 and nitrogen of 2 minutes was the optimal choice by considering the irritation of ethacridine solution, the cost of production and operation difficulty. However, more tests should be done to find out the optimal plan of production.

WANG Fangfang. Optimization of preparation formulation of ethacridine solution by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 49-50,64. doi: 10.3969/j.issn.1006-0111.2014.01.012
Citation: WANG Fangfang. Optimization of preparation formulation of ethacridine solution by orthogonal design[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 49-50,64. doi: 10.3969/j.issn.1006-0111.2014.01.012
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