ZHU Yuan-yuan, QIU Yan, LU Yi, LIU Mei, LIU Jing. Experimental study on hemostasis effect of carbonized hair[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 431-434.
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ZHU Yuan-yuan, QIU Yan, LU Yi, LIU Mei, LIU Jing. Experimental study on hemostasis effect of carbonized hair[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 431-434.
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Experimental study on hemostasis effect of carbonized hair
- Received Date: 2011-05-11
- Rev Recd Date:
2011-06-10
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Abstract
Objective To observe the hemostasis effect of carbonized hair. Methods The coagulation time was measured in vitro with blood collected from rabbits in the presence of blank, starch, carbonized hair or Yunnan White Drug-Powder respectively. Bama miniature pigs traumatic model was established and animal haemostatic experiment was performed.Hemostatic effect was observed in liver, spleen and femoral arteriovenous fistula hemorrhagic model of Bama miniature pigs. Results The coagulation time of rabbit blood was markedly shorter by addition of carbonized hair compared to Yunnan White Drug-Powder, starch and blank (P<0.05,P<0.01).Compare with the starch group, carbonized hair could significantly shorten the bleeding time and decrease the volume of bleeding (P<0.01), in the liver and spleen of hemorrhagic model of Bama miniature pigs. Compared with the Yunnan White Drug-Powder and the starch, carbonized hair could more effectively stop the femoral arteriovenous fistula bleeding in the model of Bama miniature pigs (P<0.05,P<0.01). Histologic study revealed there was no significant pathological change around the femoral artery. Conclution Carbonized hair could effectively inhibit blood coagulation in vitro, decrease bleeding volume and bleeding time in the liver and spleen of hemorrhagic model of Bama miniature pigs. Carbonized hair dressing could also effectively control hemorrhage in femoral arteriovenous fistula model with lethal vascular injury.
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