Research on the anti-fertility activity of natural products

QI Jing-jing; ZHEN Can-hui; LV Jia-guo

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Volume 29 Issue 4

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2011 > 29(4): 251-255

QI Jing-jing, ZHEN Can-hui, LV Jia-guo. Research on the anti-fertility activity of natural products[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 251-255.

Citation:

QI Jing-jing, ZHEN Can-hui, LV Jia-guo. Research on the anti-fertility activity of natural products[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 251-255.

Research on the anti-fertility activity of natural products

Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2010-09-12
Rev Recd Date: 2010-12-20

Abstract

Objective Natural products had been demonstrated with significant and extremely potent biological activities, which could provide useful leading compounds for new drug research. In recent years , it was one of the hotspots for the family planning drug research to discovery the high efficiency and good selectivity anti-fertility substance from natural products . The outline of natural product anti-fertility research was summarized concisely and the emphasis was focused on the terpenoids, alkaloids and flavonoids.
- anti-fertility,
- terpenoids,
- alkaloids,
- flavonoids

References

[1]	Sailani MR, Moeini H. Effect of ruta graveolens and cannabis sativa alcoholic extract on spermatogenesis in the adult wistar male rats[J]. Indian J Urol , 2007 , 23(3) : 257.
[2]	Lohiya NK, Manivannan B, Mishra PK, et al. Chloroform extract of carica papaya seeds induces long-term reversible azoospermia in langur monkey[J]. Asian J Androl , 2002 , 4(1) : 17.
[3]	Gershenzon J, Dudareva N. The function of terpene natural products in the natural world[J]. Nat Chem Biol , 2007 , 3(7) : 408.
[4]	Saha P, Majumdar S, Pal D, et al. Evaluation ofspermicidal activity of Mi-Saponin A[J]. Reprod Sci , 2010 , 17(5) : 454.
[5]	Vijay L, Saxena A, Pandey K, et al. Isolation of bivittoside D from sea cucumber and activity thereof[P]. US, 2005/0208147 A1 , 2005-09-22.
[6]	Lakshmi V, Saxena A, Mishra SK, et al. Spermicidal activity of bivittoside D from bohadschia vitiensis[J]. Arch Med Res , 2008 , 39(7) : 631.
[7]	Gupta RS, Bhatnager AK, Joshi YC, et al. Induction of antifertility with lupeol acetate in male albino rats[J]. Pharmacology , 2005 , 75(2) : 57.
[8]	Duan HQ, Takaishi Y, Momota H, et al. Triterpenoids from tripterygium wilfordii[J]. Phytochemistry , 2000 , 53(7) :805.
[9]	Xu RS, Fidler JM, Musser JH. Bioactive compounds from tripterygium wilfordii[J]. Stud Nat Prod Chem , 2005 , 32(12) : 773.
[10]	DarszonA, Labarca P, Nishigaki T, et al. Ion channels in sperm physiology[J]. Physiol Rev , 1999 , 79 : 481.
[11]	Bai JP, Shi YL, Fang X, et al. Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca²⁺ channels and progesterone-induced sperm acrosome reaction[J]. Eur J Pharmacol , 2003 , 464(1) : 9.
[12]	Wang HY, Zou QD, Li XL. Effect of traditional Chinese medicine on the growth and invasion of human first trimester cytotrophoblasts[J]. R & C , 2008 , 19(2) : 73.
[13]	Sang SM, Lao AN, Leng Y, et al. Segetoside F a new triterpenoid saponin with inhibition of luteal cell from the seeds of vaccaria segetalis[J]. Tetrahedron Lett , 2000 , 25 : 9205.
[14]	Sang SM, Lao AN, Leng Y, et al. A new triterpenoid saponin with inhibition of luteal cell from the seeds of vaccaria segetalis[J]. J Asian Nat Prod Res , 2002 , 4(4) : 297.
[15]	Patricio M, Milene K, Eduardo P, et al. Effect of azorellanone, a diterpene from azorella yareta hauman, on human sperm physiology[J]. J Androl , 2003 , 24(3) :364.
[16]	Shen YC, Chen CF, Chiou WF. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect[J]. Br J Pharmacol , 2002 ,135 (2) : 399.
[17]	Reddy VL, Reddy SM, Ravikanth V, et al. A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity[J]. Nat Prod Res, 2005 , 19(3) : 223.
[18]	Zhang ZJ, Jiang J, Yu P, et al. Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment[J]. J Transl Med , 2009 , 7 : 62.
[19]	Shi MD, Lin HH, Lee YC, et al. Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide[J]. Chem Biol Interact , 2008 , 174(13) : 201.
[20]	Kumar S, Naskar S, Hazra A, et al. Evaluation of spermicidal potential of labdane diterpenes from Andrographis paniculata[J]. Int J Biochem , 2009 , 3(4) : 221.
[21]	Akbarsha MA, Murugaian P. Aspects of the male reproductive toxicity/ male antifertility property of andrographolide in albino rats: effect on thetestis and the cauda epididymidal spermatozoa[J]. Phytotherapy Research , 2000 , 14(6) : 432.
[22]	王伟成, 陈荣发, 赵世兴, 等. 土槿皮乙酸的抗生育作用[J] 中国药理学报, 1982, 3(3) : 185.
[23]	陈浩洪, 顾芝萍, 游根娣, 等. 人蜕皮细胞培养作为抗早孕药物筛选模型的研究[J]. 上海铁道大学学报, 1998 , 19(11) :1.
[24]	Matlin SA, Zhou R, Bialy G, et al. (-)-Gossypol: an active male antifertility agent[J]. Contraception , 1985 , 31 :141.
[25]	楚世峰, 王玉珠, 郑里翔, 等. 棉酚造成大鼠精子质量下降与NO之间关系的研究[J]. 中国药理学通报, 2008 , 24(11): 1518 .
[26]	Stipanovic RD, Puckhaber LS, Bell AA, et al. Occurrence of (+)-and (-)-gossypol in wild species of cotton and in Gossypium hirsutum Var. mariegalante (Watt) Hutchinson[J]. J Agric Food Chem , 2005 , 53(16) : 6266.
[27]	OuYang XK, Jin MC, He CH. Simultaneous determination of four sesquiterpene alkaloids in tripterygium wilfordii Hook. F. extracts by high-performance liquid chromatography[J]. Phytochem Anal , 2007 , 18(4) : 320.
[28]	Yuvaraj G, Vijayalakshmi M, Sandeep G. et al. Antifertility Activity of the ethanolic extract of cassia occidentalis,derris brevipes variety brevipes and justicia simplex[J]. World J Chem , 2009 , 4(2) : 118.
[29]	Udoh FV, Udoh PB, Umoh EE. Activity of alkaloid extract of carica papaya seeds on reproductive functions in male wistar rats[J]. Pharm Biol , 2005 , 43(6) : 563.
[30]	Keshri G, Oberoi RM, Lakshmi V, et al. Contraceptive and hormonal properties of the stem bark of dysoxylum binectariferum in rat and docking analysis of rohitukine, the alkaloid isolated from active chloroform soluble fraction[J]. Contraception , 2007 , 76 : 400.
[31]	Srivastav A, Chandra A, Singh M, et al. Inhibition of hyaluronidase activity of human and rat spermatozoa in vitro and antispermatogenic activity in rats in vivo by terminalia chebula,a flavonoid rich plant[J]. Reproductive Toxicology , 2010 , 29(2) : 214.
[32]	Taitzoglou IA, Tsantarliotou M,Zervos I, et al. Inhibition of human and ovine acrosomal enzymes by tannic acid in vitro[J]. J Reprod Fertil , 2001 , 121(1) : 131.
[33]	Shivayogi PH, Shrishailappa B, Shanmukhaswamy KH, et al. Antifertility and hormonal properties of flavones of Striga orobanchioides[J]. Eur J Pharmacol , 2000 , 391(1-2) : 193.

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通讯作者: 陈斌, [email protected]

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沈阳化工大学材料科学与工程学院沈阳 110142

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Research on the anti-fertility activity of natural products

Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2010-09-12

Rev Recd Date: 2010-12-20

Key words:

Abstract: Objective Natural products had been demonstrated with significant and extremely potent biological activities, which could provide useful leading compounds for new drug research. In recent years , it was one of the hotspots for the family planning drug research to discovery the high efficiency and good selectivity anti-fertility substance from natural products . The outline of natural product anti-fertility research was summarized concisely and the emphasis was focused on the terpenoids, alkaloids and flavonoids.

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Reference (33)

[1]	Sailani MR, Moeini H. Effect of ruta graveolens and cannabis sativa alcoholic extract on spermatogenesis in the adult wistar male rats[J]. Indian J Urol , 2007 , 23(3) : 257.
[2]	Lohiya NK, Manivannan B, Mishra PK, et al. Chloroform extract of carica papaya seeds induces long-term reversible azoospermia in langur monkey[J]. Asian J Androl , 2002 , 4(1) : 17.
[3]	Gershenzon J, Dudareva N. The function of terpene natural products in the natural world[J]. Nat Chem Biol , 2007 , 3(7) : 408.
[4]	Saha P, Majumdar S, Pal D, et al. Evaluation ofspermicidal activity of Mi-Saponin A[J]. Reprod Sci , 2010 , 17(5) : 454.
[5]	Vijay L, Saxena A, Pandey K, et al. Isolation of bivittoside D from sea cucumber and activity thereof[P]. US, 2005/0208147 A1 , 2005-09-22.
[6]	Lakshmi V, Saxena A, Mishra SK, et al. Spermicidal activity of bivittoside D from bohadschia vitiensis[J]. Arch Med Res , 2008 , 39(7) : 631.
[7]	Gupta RS, Bhatnager AK, Joshi YC, et al. Induction of antifertility with lupeol acetate in male albino rats[J]. Pharmacology , 2005 , 75(2) : 57.
[8]	Duan HQ, Takaishi Y, Momota H, et al. Triterpenoids from tripterygium wilfordii[J]. Phytochemistry , 2000 , 53(7) :805.
[9]	Xu RS, Fidler JM, Musser JH. Bioactive compounds from tripterygium wilfordii[J]. Stud Nat Prod Chem , 2005 , 32(12) : 773.
[10]	DarszonA, Labarca P, Nishigaki T, et al. Ion channels in sperm physiology[J]. Physiol Rev , 1999 , 79 : 481.
[11]	Bai JP, Shi YL, Fang X, et al. Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca²⁺ channels and progesterone-induced sperm acrosome reaction[J]. Eur J Pharmacol , 2003 , 464(1) : 9.
[12]	Wang HY, Zou QD, Li XL. Effect of traditional Chinese medicine on the growth and invasion of human first trimester cytotrophoblasts[J]. R & C , 2008 , 19(2) : 73.
[13]	Sang SM, Lao AN, Leng Y, et al. Segetoside F a new triterpenoid saponin with inhibition of luteal cell from the seeds of vaccaria segetalis[J]. Tetrahedron Lett , 2000 , 25 : 9205.
[14]	Sang SM, Lao AN, Leng Y, et al. A new triterpenoid saponin with inhibition of luteal cell from the seeds of vaccaria segetalis[J]. J Asian Nat Prod Res , 2002 , 4(4) : 297.
[15]	Patricio M, Milene K, Eduardo P, et al. Effect of azorellanone, a diterpene from azorella yareta hauman, on human sperm physiology[J]. J Androl , 2003 , 24(3) :364.
[16]	Shen YC, Chen CF, Chiou WF. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect[J]. Br J Pharmacol , 2002 ,135 (2) : 399.
[17]	Reddy VL, Reddy SM, Ravikanth V, et al. A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity[J]. Nat Prod Res, 2005 , 19(3) : 223.
[18]	Zhang ZJ, Jiang J, Yu P, et al. Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment[J]. J Transl Med , 2009 , 7 : 62.
[19]	Shi MD, Lin HH, Lee YC, et al. Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide[J]. Chem Biol Interact , 2008 , 174(13) : 201.
[20]	Kumar S, Naskar S, Hazra A, et al. Evaluation of spermicidal potential of labdane diterpenes from Andrographis paniculata[J]. Int J Biochem , 2009 , 3(4) : 221.
[21]	Akbarsha MA, Murugaian P. Aspects of the male reproductive toxicity/ male antifertility property of andrographolide in albino rats: effect on thetestis and the cauda epididymidal spermatozoa[J]. Phytotherapy Research , 2000 , 14(6) : 432.
[22]	王伟成, 陈荣发, 赵世兴, 等. 土槿皮乙酸的抗生育作用[J] 中国药理学报, 1982, 3(3) : 185.
[23]	陈浩洪, 顾芝萍, 游根娣, 等. 人蜕皮细胞培养作为抗早孕药物筛选模型的研究[J]. 上海铁道大学学报, 1998 , 19(11) :1.
[24]	Matlin SA, Zhou R, Bialy G, et al. (-)-Gossypol: an active male antifertility agent[J]. Contraception , 1985 , 31 :141.
[25]	楚世峰, 王玉珠, 郑里翔, 等. 棉酚造成大鼠精子质量下降与NO之间关系的研究[J]. 中国药理学通报, 2008 , 24(11): 1518 .
[26]	Stipanovic RD, Puckhaber LS, Bell AA, et al. Occurrence of (+)-and (-)-gossypol in wild species of cotton and in Gossypium hirsutum Var. mariegalante (Watt) Hutchinson[J]. J Agric Food Chem , 2005 , 53(16) : 6266.
[27]	OuYang XK, Jin MC, He CH. Simultaneous determination of four sesquiterpene alkaloids in tripterygium wilfordii Hook. F. extracts by high-performance liquid chromatography[J]. Phytochem Anal , 2007 , 18(4) : 320.
[28]	Yuvaraj G, Vijayalakshmi M, Sandeep G. et al. Antifertility Activity of the ethanolic extract of cassia occidentalis,derris brevipes variety brevipes and justicia simplex[J]. World J Chem , 2009 , 4(2) : 118.
[29]	Udoh FV, Udoh PB, Umoh EE. Activity of alkaloid extract of carica papaya seeds on reproductive functions in male wistar rats[J]. Pharm Biol , 2005 , 43(6) : 563.
[30]	Keshri G, Oberoi RM, Lakshmi V, et al. Contraceptive and hormonal properties of the stem bark of dysoxylum binectariferum in rat and docking analysis of rohitukine, the alkaloid isolated from active chloroform soluble fraction[J]. Contraception , 2007 , 76 : 400.
[31]	Srivastav A, Chandra A, Singh M, et al. Inhibition of hyaluronidase activity of human and rat spermatozoa in vitro and antispermatogenic activity in rats in vivo by terminalia chebula,a flavonoid rich plant[J]. Reproductive Toxicology , 2010 , 29(2) : 214.
[32]	Taitzoglou IA, Tsantarliotou M,Zervos I, et al. Inhibition of human and ovine acrosomal enzymes by tannic acid in vitro[J]. J Reprod Fertil , 2001 , 121(1) : 131.
[33]	Shivayogi PH, Shrishailappa B, Shanmukhaswamy KH, et al. Antifertility and hormonal properties of flavones of Striga orobanchioides[J]. Eur J Pharmacol , 2000 , 391(1-2) : 193.

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Research on the anti-fertility activity of natural products

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通讯作者: 陈斌, [email protected]

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