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Volume 26 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (3): 197-199,232

YU Da-hai. Effects and mechanism of Acanthopanax senticosus saponins on myocardial ischemia and reperfusion in rats[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 197-199,232.
Citation: YU Da-hai. Effects and mechanism of Acanthopanax senticosus saponins on myocardial ischemia and reperfusion in rats[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 197-199,232.
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Effects and mechanism of Acanthopanax senticosus saponins on myocardial ischemia and reperfusion in rats

  • The 404th Hospital of PLA,Weihai 264200,China

  • Received Date: 2007-10-09
  • Objective: To observe the protective effect of acanthopanax senticosus saponins(ASS) on myocardial ischemia-reperfusion in rats and to find a possible mechanism. Methods: An in vitro myocardial injury model was made by 30 min of ischemia followed by 30 min of reperfusion in the isolated rat heart from anesthetized rat.The change of heart function and coronary flow in normal and reperfusion conditions were observed. Results: ASS can improve the heart function at the dose of 20 mg/L;and at the dose of 10 mg/L and 20 mg/L ASS it can increase the coronary flow in normal and reperfusion conditions at dose-dependent ways;The effects can be cancelled by nitric oxide syntheses inhibitor. Conclusion: ASS has a weak influence on the normal heart function in vitro rats heart,but significantly improve the heart function after myocardial ischemia and reperfusion in rats.This mechanism may be related to the improvement in the myocardial ischemia and the coronary artery through increasing the nitric oxide.
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Effects and mechanism of Acanthopanax senticosus saponins on myocardial ischemia and reperfusion in rats

  • The 404th Hospital of PLA,Weihai 264200,China
  • Received Date: 2007-10-09

Abstract: Objective: To observe the protective effect of acanthopanax senticosus saponins(ASS) on myocardial ischemia-reperfusion in rats and to find a possible mechanism. Methods: An in vitro myocardial injury model was made by 30 min of ischemia followed by 30 min of reperfusion in the isolated rat heart from anesthetized rat.The change of heart function and coronary flow in normal and reperfusion conditions were observed. Results: ASS can improve the heart function at the dose of 20 mg/L;and at the dose of 10 mg/L and 20 mg/L ASS it can increase the coronary flow in normal and reperfusion conditions at dose-dependent ways;The effects can be cancelled by nitric oxide syntheses inhibitor. Conclusion: ASS has a weak influence on the normal heart function in vitro rats heart,but significantly improve the heart function after myocardial ischemia and reperfusion in rats.This mechanism may be related to the improvement in the myocardial ischemia and the coronary artery through increasing the nitric oxide.

YU Da-hai. Effects and mechanism of Acanthopanax senticosus saponins on myocardial ischemia and reperfusion in rats[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 197-199,232.
Citation: YU Da-hai. Effects and mechanism of Acanthopanax senticosus saponins on myocardial ischemia and reperfusion in rats[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 197-199,232.
shu

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