Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 26 Issue 3
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (3): 185-187

CAO Wei-wei, LU bo. Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 185-187.
Citation: CAO Wei-wei, LU bo. Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 185-187.
shu

Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents

  • Department of Pharmacy,411 Hospital of PLA,Shanghai 200081,China

  • Received Date: 2007-07-24
  • Objective: To investigate the antidepressant activity of Centalla asiatic triterpenic acid(CATA),and its main comstituerts asiatic acid(AA) and madecassic acid(MA). Methods: The forced swimming test(FST),tail suspension test(TST),open field activity(OFA) test and reserpine-induced ptosis test were carried out to examine the antidepressant activity in mice.Mice immobility duration in FST and TST,spontaneous activity frequency in OFA,and ptosis in reserpine antagonistic test were observed. Results: CATA,AA and MA could significantly shorten mice immobility time in FST at the dosages of 60 and 120 mg/kg and could markedly shorten mice immobility time in TST at the dosages of 30,60 and 120 mg/kg.They could not reduce mice spontaneous activity in OFA.CATA,AA and MA could reduce ptosis mice in reserpine antagonistic test. Conclusion: CATA,AA and MA exert an antidepressant activity in animal models.
  • 加载中
通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2707) PDF downloads(579) Cited by()

Related
Proportional views

Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents

  • Department of Pharmacy,411 Hospital of PLA,Shanghai 200081,China
  • Received Date: 2007-07-24

Abstract: Objective: To investigate the antidepressant activity of Centalla asiatic triterpenic acid(CATA),and its main comstituerts asiatic acid(AA) and madecassic acid(MA). Methods: The forced swimming test(FST),tail suspension test(TST),open field activity(OFA) test and reserpine-induced ptosis test were carried out to examine the antidepressant activity in mice.Mice immobility duration in FST and TST,spontaneous activity frequency in OFA,and ptosis in reserpine antagonistic test were observed. Results: CATA,AA and MA could significantly shorten mice immobility time in FST at the dosages of 60 and 120 mg/kg and could markedly shorten mice immobility time in TST at the dosages of 30,60 and 120 mg/kg.They could not reduce mice spontaneous activity in OFA.CATA,AA and MA could reduce ptosis mice in reserpine antagonistic test. Conclusion: CATA,AA and MA exert an antidepressant activity in animal models.

CAO Wei-wei, LU bo. Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 185-187.
Citation: CAO Wei-wei, LU bo. Antidepressant activity of Centalla Asiatic Triterpenic acid and its main constituents[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 185-187.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return