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Volume 26 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (3): 175-177,190

XU Yong, HUANG Xiao-jin, XU Jian-ming, CAI Ling-zhi, SONG Yan, ZHAO Qing-jie, Wu Qiu-ye. Synthesis and the antiplatelet aggregative activity of 4,5-dihydro-3(2 H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 175-177,190.
Citation: XU Yong, HUANG Xiao-jin, XU Jian-ming, CAI Ling-zhi, SONG Yan, ZHAO Qing-jie, Wu Qiu-ye. Synthesis and the antiplatelet aggregative activity of 4,5-dihydro-3(2 H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 175-177,190.
shu

Synthesis and the antiplatelet aggregative activity of 4,5-dihydro-3(2 H)-pyridazinones

  • 1.

    No.85 Hospital of PLA,Shanghai,200052,China

  • 2.

    Department of Organnic Chemistry,School of Pharmcy,Second military Medical University,Shanghai,200433,China

  • Received Date: 2008-03-03
  • Objective: To study the antiplatelet aggregative activity of 6-(4-substituted acetamido-phenyl)-4,5-dihydro-3(2H)-pyridazinones inletting different piperazine groups. Methods: Ten target compounds were designed and synthesized.All of them were confirmed by 1H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggregative activity to a certain extent.Compound(1)/(4)and performed better than MCI-154 in vitro. Conclusion: The carbochain’s length of piperazine’s 4-substituted groups impacted the antiplatelet aggregative activity promintly.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Synthesis and the antiplatelet aggregative activity of 4,5-dihydro-3(2 H)-pyridazinones

  • 1. No.85 Hospital of PLA,Shanghai,200052,China
  • 2. Department of Organnic Chemistry,School of Pharmcy,Second military Medical University,Shanghai,200433,China
  • Received Date: 2008-03-03

Abstract: Objective: To study the antiplatelet aggregative activity of 6-(4-substituted acetamido-phenyl)-4,5-dihydro-3(2H)-pyridazinones inletting different piperazine groups. Methods: Ten target compounds were designed and synthesized.All of them were confirmed by 1H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggregative activity to a certain extent.Compound(1)/(4)and performed better than MCI-154 in vitro. Conclusion: The carbochain’s length of piperazine’s 4-substituted groups impacted the antiplatelet aggregative activity promintly.

XU Yong, HUANG Xiao-jin, XU Jian-ming, CAI Ling-zhi, SONG Yan, ZHAO Qing-jie, Wu Qiu-ye. Synthesis and the antiplatelet aggregative activity of 4,5-dihydro-3(2 H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 175-177,190.
Citation: XU Yong, HUANG Xiao-jin, XU Jian-ming, CAI Ling-zhi, SONG Yan, ZHAO Qing-jie, Wu Qiu-ye. Synthesis and the antiplatelet aggregative activity of 4,5-dihydro-3(2 H)-pyridazinones[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 175-177,190.
shu

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