Clinial observation of rectal administration of morphine sulfate controlled-re-lease tablets for treatment of cancer pain

Key words: 
• cancer pain /
• morphine sulfate controlled-release tablets /
• rectal administration

Abstract: Objective To evaluate the analgesic effect, the life quality and toxic action of rectal administration of morphine sulfate controlled-release tablets (MST) in patients with oral administration.Methods 41 patients with cancer pain and with nausea, vomiting, obstruction and dysphagia were treated with rectal administration of MST, 12h a cycle.For comparision, 32 patients were treated with oral administration of MST, 12h a cycle.Results The total effective rate of the group of rectal administration was 97.56%.Incidence of the toxic action was 19.52%.Karnofsky was advanced from(45.24 ± 8.21) to (66.22 ±11.6) ;The total effective rate of the oral morphine group was 96.87%.Incidence of the toxic action was 56.24%.Karnofsky was advanced from (47.81 ± 12.11) to (66.72 ± 10.36).Analgesic effect and the life quality showed statistical significant difference between the two groups (P > 0.05).Toxicity showed statistical difference between the two groups (P < 0.01).Conclusion Rectal administration of MST for treatment of cancer pain was as effective as oral administration of MST.But the side effects was mild.The rectal administration of MST is fit especially for the patients, that oral administration is not available.