Studies on bioavailability of nimodipine soft capsules in healthy volunteer

Cai Changchun; Li Jingsu; Yang Zunxiang; Xie Xiaochan

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Volume 15 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 1997 > (5): 288-290

Cai Changchun, Li Jingsu, Yang Zunxiang, Xie Xiaochan. Studies on bioavailability of nimodipine soft capsules in healthy volunteer[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 288-290.

Citation:

Cai Changchun, Li Jingsu, Yang Zunxiang, Xie Xiaochan. Studies on bioavailability of nimodipine soft capsules in healthy volunteer[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 288-290.

Studies on bioavailability of nimodipine soft capsules in healthy volunteer

The Bethune International Peace Hospital, Shijiazhuang 050082

Abstract

A single oral dose of tablets or soft capsules of 60mg nimodipine was given to 8 healthy volunteers in a randomized crossover study.plasma levels were determined with HPLC method.The plasma concentration-time curve fitted 1-compartment open model,and 2 dose comparative T_max,C_max,AUC were not significantly different from that of the tablets(P>0.05).Although the sofe capsules could reach peak level faster,the bioavailability with same biological effect.
- nimodipine soft capsules,
- bioavailability,
- HPLC method
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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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