HUANG Jin, LI Luyi, QI Weigang, HUANG Ying, ZENG Ying, TANG Fan. Regulating effect of Xuefuzhuyu capsule on clopidogrel resistance in patients with severe blood stasis syndrome after PCI operation[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 533-535,546. doi: 10.3969/j.issn.1006-0111.2018.06.012
| Citation:
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HUANG Jin, LI Luyi, QI Weigang, HUANG Ying, ZENG Ying, TANG Fan. Regulating effect of Xuefuzhuyu capsule on clopidogrel resistance in patients with severe blood stasis syndrome after PCI operation[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 533-535,546. doi: 10.3969/j.issn.1006-0111.2018.06.012
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Regulating effect of Xuefuzhuyu capsule on clopidogrel resistance in patients with severe blood stasis syndrome after PCI operation
- 1.
Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Pudong New Aera People's Hospital, Shanghai 201299, China
- 2.
Department of Pharmacy, Pudong New Aera People's Hospital, Shanghai 201299, China
- 3.
Department of Cardiology, Pudong New Aera People's Hospital, Shanghai 201299, China
- Received Date: 2018-04-08
- Rev Recd Date:
2018-07-03
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Abstract
Objective To observe and evaluate the regulating effect of Xuefuzhuyu capsule combined with clopidogrel on clopidogrel resistance. Methods After PCI operation, 80 patients with clopidogrel resistance were randomly divided into three different treatments,A:clopidogrel (Tai Jia) combined with Xuefuzhuyu capsule; B:clopidogrel (Plavix); C:clopidogrel (Tai Jia) combined with cilostazol.)After three months of continuous medication, and the inhibition rate of platelet aggregation was detected by thromboela-stogram(TEG).The patients were followed up for half a year to observe the incidence of adverse events. Results After three months of treatment, the inhibition rates of the three groups were improved(P<0.05).The effective rate of platelet inhibition in group A was 40% (10/25), which was higher to group C (33.33%), and which was equivalent to group B (40.74%). The effect of platelet aggregation inhibition was better in patients who were not sensitive to aspirin and clopidogrel and then with imported Plavix. And the treatment group of clopidogrel combined with Xuefuzhuyu capsule had a synergistic effect on platelet aggregation inhibition for clopidogrel insensitive patients. After six months' follow-up, it was found that the platelet inhibition was enhanced but the bleeding risk and abnormal coagulation function was not increased after prolonged using of Xuefuzhuyu capsule. Conclusion Xuefuzhuyu capsule had a certain effect on improving the inhibition rate of platelet aggregation, which had little effect on the risk of bleeding.
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