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Volume 34 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(5): 403-407,415

GAO Yue, CHEN Anni, ZHAO Yahong, XUE Dan, AN Yongtong, CHAI Yifeng, ZHANG Hai. Experimental study on the effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 403-407,415. doi: 10.3969/j.issn.1006-0111.2016.05.006
Citation: GAO Yue, CHEN Anni, ZHAO Yahong, XUE Dan, AN Yongtong, CHAI Yifeng, ZHANG Hai. Experimental study on the effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 403-407,415. doi: 10.3969/j.issn.1006-0111.2016.05.006
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Experimental study on the effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury

doi: 10.3969/j.issn.1006-0111.2016.05.006
  • 1.

    Center of Experimental Teaching, College of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital of Second Military Medical University, Shanghai, 200438, China

  • 3.

    Central Research Institute, Shanghai Pharmaceuticals Holding Co.Ltd., Shanghai 200123, China

  • Received Date: 2016-07-20
  • Rev Recd Date: 2016-08-23
  • Objective Experimental study on effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury in order to provide a theoretical basis for its clinical application. Method Rat model of chronic ischemic heart failure and acute ischemia reperfusion mouse model of myocardial infarction were constructed through coronary artery ligation. Those animals were randomized to sham operation group, model group, positive drug group, high Yangxinshi tablet dose group, middle Yangxinshi tablet dose group, low Yangxinshi tablet dose group. Rat electrocardiogram, ultrasound, ACE, ACD, TNF-a, mouse myocardial infarction area, CK, LDH, SOD and related factors were recorded during pre-dosing and post-dosing after modeling. Morphological changes were observed with cardiac pathological section. Results The biochemical indicators in model group were significantly different from sham operation group with statistical significance (P<0.001). Compared to the model group, positive drug group and high Yangxinshi tablet dose group exhibited biochemical differences with statistical significance (P<0.001, P<0.01, P<0.05), significant myocardial infarction area reduction (P<0.01, P<0.05), improvement in myocardial cells and reduction in the cell infiltration. Conclusion Yangxinshi tablets have preventive and therapeutic effects on chronic ischemic heart failure and acute ischemia reperfusion injury.
  • [1] 姜作玲,高 莉, 王 辉,等.养心氏片对大鼠冠脉结扎致心肌缺血模型的影响[J].世界中医药,2015,10(4):553-556.
    [2] 崔 燕,张 辉,庄 婕.养心氏片治疗心绞痛及冠心病临床试验资料研究[J].食品与药品, 2013,15(4):293-295.
    [3] 盘 锋.养心氏片辅助治疗舒张性心力衰竭80例疗效观察[J].中医临床研究,2014,6(18):39-41.
    [4] 瞿家武,虞江灏.养心氏片治疗慢性心力衰竭临床疗效观察[J].实用临床医药杂志,2010,14(15):89-97.
    [5] 王 靓,黄金玲,施 慧,等.对慢性心力衰竭实验动物模型制作方法的研究进展[J].当代医药论丛,2014,12(10):291-293.
    [6] 韩 曼,马 莉,于远望.2种慢性心力衰竭大鼠模型的建立[J].新乡医学院学报,2015,32(11):992-995.
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Experimental study on the effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury

doi: 10.3969/j.issn.1006-0111.2016.05.006
  • 1. Center of Experimental Teaching, College of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital of Second Military Medical University, Shanghai, 200438, China
  • 3. Central Research Institute, Shanghai Pharmaceuticals Holding Co.Ltd., Shanghai 200123, China
  • Received Date: 2016-07-20
  • Rev Recd Date: 2016-08-23

Abstract: Objective Experimental study on effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury in order to provide a theoretical basis for its clinical application. Method Rat model of chronic ischemic heart failure and acute ischemia reperfusion mouse model of myocardial infarction were constructed through coronary artery ligation. Those animals were randomized to sham operation group, model group, positive drug group, high Yangxinshi tablet dose group, middle Yangxinshi tablet dose group, low Yangxinshi tablet dose group. Rat electrocardiogram, ultrasound, ACE, ACD, TNF-a, mouse myocardial infarction area, CK, LDH, SOD and related factors were recorded during pre-dosing and post-dosing after modeling. Morphological changes were observed with cardiac pathological section. Results The biochemical indicators in model group were significantly different from sham operation group with statistical significance (P<0.001). Compared to the model group, positive drug group and high Yangxinshi tablet dose group exhibited biochemical differences with statistical significance (P<0.001, P<0.01, P<0.05), significant myocardial infarction area reduction (P<0.01, P<0.05), improvement in myocardial cells and reduction in the cell infiltration. Conclusion Yangxinshi tablets have preventive and therapeutic effects on chronic ischemic heart failure and acute ischemia reperfusion injury.

GAO Yue, CHEN Anni, ZHAO Yahong, XUE Dan, AN Yongtong, CHAI Yifeng, ZHANG Hai. Experimental study on the effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 403-407,415. doi: 10.3969/j.issn.1006-0111.2016.05.006
Citation: GAO Yue, CHEN Anni, ZHAO Yahong, XUE Dan, AN Yongtong, CHAI Yifeng, ZHANG Hai. Experimental study on the effects of Yangxinshi tablets in the prevention and treatment of chronic ischemic heart failure and acute myocardial ischemia reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 403-407,415. doi: 10.3969/j.issn.1006-0111.2016.05.006
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