Olaparib: a new drug for hereditary ovarian cancer treatment

TANG Yuenian; JIN Liang; SUN Chaorong

doi:10.3969/j.issn.1006-0111.2015.04.022

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Olaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, and was developed by AstraZeneca Pharmaceuticals LP. Olaparib has therapeutic potential for treating cancers associated with impaired DNA repair capabilities, particularly those with deficiencies in the homologous recombination repair (HRR) pathway. Olaparib is an available therapy option for ovarian cancer patients with deficiencies in the BRCA1 and BRCA2 genes. Olaparib can selectively kill cancer cells without compromising normal cells. Compared to traditional chemotherapy means, adverse reactions are much smaller.

Olaparib: a new drug for hereditary ovarian cancer treatment

Department of Pharmacy, Xinhua Hospital, Sechool of Medicine, Shanghai Jiaotong University, Shanghai 200092

Received Date: 2015-02-02

Rev Recd Date: 2015-04-29

Key words:

olaparib /
hereditary /
ovarian cancer

Abstract: Olaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, and was developed by AstraZeneca Pharmaceuticals LP. Olaparib has therapeutic potential for treating cancers associated with impaired DNA repair capabilities, particularly those with deficiencies in the homologous recombination repair (HRR) pathway. Olaparib is an available therapy option for ovarian cancer patients with deficiencies in the BRCA1 and BRCA2 genes. Olaparib can selectively kill cancer cells without compromising normal cells. Compared to traditional chemotherapy means, adverse reactions are much smaller.

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[8]	Norris RE, Adamson PC, Nguyen VT,et al. Preclinical evaluation of the PARP inhibitor, olaparib, in combination with cytotoxic chemotherapy in pediatric solid tumors[J]. Pediatr Blood Cancer, 2014 61 (1): 145-150.
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Olaparib: a new drug for hereditary ovarian cancer treatment

doi: 10.3969/j.issn.1006-0111.2015.04.022

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通讯作者: 陈斌, [email protected]

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