CHEN Hao, YE Ji, LIU Jiangyun, ZHANG Weidong, SUN Qingyan. Total synthesis of the natural product of crinumaquine[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 331-333. doi: 10.3969/j.issn.1006-0111.2015.04.011
| Citation:
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CHEN Hao, YE Ji, LIU Jiangyun, ZHANG Weidong, SUN Qingyan. Total synthesis of the natural product of crinumaquine[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 331-333. doi: 10.3969/j.issn.1006-0111.2015.04.011
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Total synthesis of the natural product of crinumaquine
- 1.
School of Pharmacy, Soochow University, Suzhou 215123, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- 2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- 3.
School of Pharmacy, Soochow University, Suzhou 215123, China
- Received Date: 2014-05-30
- Rev Recd Date:
2014-09-09
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Abstract
Objective To complete the synthesis of the natural product of crinumaquine. Methods 3,4-methylenedioxyphenethylamine and 2,5-dimthoxyphenylacetic were taken as starting material, and chemical reactions of condensation, cyclization, reduction, oxidation and other reactions were conducted. Results and Conclusion The optimum synthetic route was determinedunder which the final yield rate was 73%.
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