LI Wenjuan, LI Renwu, WU Maocheng, WANG Fuzhe, QIN Liping, LI Bai, HU Honggang. Solid-phase synthesis of melittin of anti-tumor peptide[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 51-52. doi: 10.3969/j.issn.1006-0111.2014.01.013
| Citation:
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LI Wenjuan, LI Renwu, WU Maocheng, WANG Fuzhe, QIN Liping, LI Bai, HU Honggang. Solid-phase synthesis of melittin of anti-tumor peptide[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 51-52. doi: 10.3969/j.issn.1006-0111.2014.01.013
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Solid-phase synthesis of melittin of anti-tumor peptide
- 1.
School of Pharmacy, Yantai University, Yantai 264005, China
- 2.
Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Second Military Medical University, Shanghai 200433, China
- 3.
Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
- Received Date: 2012-12-16
- Rev Recd Date:
2013-08-31
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Abstract
Objective To synthesize the antitumor activity of twenty-six peptide melittin. Methods The melittin was synthesized by stepwise solid-phase peptide synthesis (SPPS). During the synthesis of melittin, wang-resin was chosen as solid supporter and HOBt/DCC were used as the coupling reagent. Results The melittin was synthesized with yield of 32%. Conclusion The synthetic method was feasible, simple and with high yield for long chain polypeptide synthesis.
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References
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