Meta-analysis of effect and safety of standard regimens and weekly regimens of topotecan treating NSCLC

CAI Heping; WANG Zhuo

doi:10.3969/j.issn.1006-0111.2014.01.006

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Objective To compare the effect and safety of the two regimens of topotecan by means of Meta-analysis, in order to give evidences for doctors when selecting regimens. Methods All the studies that have been searched in Pub Med from setup data base to 2013-07-10 were evaluated strictly and meta-analysis was used to study the effect and safety of two regimens contain standard regimens and weekly regimens. The odds radio(OR) was calculate for incidence of efficiency and safety of two regimens. Results Totally 3 studies including 288 cases were analyzed in efficiency. 17 cases were effective in 165 cases of weekly regimens; 21 cases were effective in 123 cases of standard regimens. Totally 2 studies including 132 cases were analyzed in safety. 89 cases were in weekly regimens. Of which 26 cases of Ⅲ/Ⅳ neutropenia and 17cases of Ⅲ/Ⅳ low-hemoglobin and 32 cases of Ⅲ/Ⅳ thrombopenia. 43 cases were in standard regimens. Of which 39 cases of Ⅲ/Ⅳ neutropenia and 24 cases of Ⅲ/Ⅳ low-hemoglobin and 32 cases of Ⅲ/Ⅳ thrombopenia. The pooled OR of efficiency was 0.49 with a 95% confidence interval(0.23-1.01);the pooled OR of Ⅲ/Ⅳ neutropenia was 0.04 with a 95% confidence interval(0.01-0.14); the pooled OR of Ⅲ/Ⅳ low-hemoglobin was 0.27 with a 95% confidence interval(0.11-0.63); the pooled OR of Ⅲ/Ⅳ thrombopenia was 0.12 with a 95% confidence interval(0.04-0.32). Conclusion Weekly regimens group compared to standard regimens group in efficiency had no statistical significance; Weekly regimens group compared to standard regimens group for preventing Ⅲ/Ⅳ neutropenia, Ⅲ/Ⅳ low-hemoglobin and Ⅲ/Ⅳ thrombopenia had statistical significance. Weekly regimens group was better to standard regimens group for preventing Ⅲ/Ⅳ neutropenia, Ⅲ/Ⅳ low-hemoglobin and Ⅲ/Ⅳ thrombopenia.

Meta-analysis of effect and safety of standard regimens and weekly regimens of topotecan treating NSCLC

Department of Pharmacy, Changhai Hospital Afilliated to Second Military Medical University, Shanghai 200433, China

Received Date: 2013-12-11

Rev Recd Date: 2014-01-08

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Abstract: Objective To compare the effect and safety of the two regimens of topotecan by means of Meta-analysis, in order to give evidences for doctors when selecting regimens. Methods All the studies that have been searched in Pub Med from setup data base to 2013-07-10 were evaluated strictly and meta-analysis was used to study the effect and safety of two regimens contain standard regimens and weekly regimens. The odds radio(OR) was calculate for incidence of efficiency and safety of two regimens. Results Totally 3 studies including 288 cases were analyzed in efficiency. 17 cases were effective in 165 cases of weekly regimens; 21 cases were effective in 123 cases of standard regimens. Totally 2 studies including 132 cases were analyzed in safety. 89 cases were in weekly regimens. Of which 26 cases of Ⅲ/Ⅳ neutropenia and 17cases of Ⅲ/Ⅳ low-hemoglobin and 32 cases of Ⅲ/Ⅳ thrombopenia. 43 cases were in standard regimens. Of which 39 cases of Ⅲ/Ⅳ neutropenia and 24 cases of Ⅲ/Ⅳ low-hemoglobin and 32 cases of Ⅲ/Ⅳ thrombopenia. The pooled OR of efficiency was 0.49 with a 95% confidence interval(0.23-1.01);the pooled OR of Ⅲ/Ⅳ neutropenia was 0.04 with a 95% confidence interval(0.01-0.14); the pooled OR of Ⅲ/Ⅳ low-hemoglobin was 0.27 with a 95% confidence interval(0.11-0.63); the pooled OR of Ⅲ/Ⅳ thrombopenia was 0.12 with a 95% confidence interval(0.04-0.32). Conclusion Weekly regimens group compared to standard regimens group in efficiency had no statistical significance; Weekly regimens group compared to standard regimens group for preventing Ⅲ/Ⅳ neutropenia, Ⅲ/Ⅳ low-hemoglobin and Ⅲ/Ⅳ thrombopenia had statistical significance. Weekly regimens group was better to standard regimens group for preventing Ⅲ/Ⅳ neutropenia, Ⅲ/Ⅳ low-hemoglobin and Ⅲ/Ⅳ thrombopenia.

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Reference (8)

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Meta-analysis of effect and safety of standard regimens and weekly regimens of topotecan treating NSCLC

doi: 10.3969/j.issn.1006-0111.2014.01.006

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通讯作者: 陈斌, [email protected]

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