Preparation and application of solid lipid nano-particles

XIA Ai-xiao; SONG Qian-qian; SUN yuan

doi:10.3969/j.issn.1006-0111.2012.05.003

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Objective To review the latest research progress of the solid lipid nano-particle. Methods Domestic and foreign representative literature information of solid lipid nano-particles and its application were analyzed and summarized. Results Many kinds of preparation methods of solid lipid nano-particle had advantages and disadvantages, the high pressure homogenization technique and micro-emulsion method were recommended. Adjusting preparation parameters could be adjusted drug encapsulation efficiency and drug delivering curve. Conclusion Solid lipid nano-particle was a kind of excellent performance, which could be promising new drug delivery system.

Preparation and application of solid lipid nano-particles

1. Department of Pharmacy, Taizhou hospital of Zhejiang Province, Linhai 317000, China

2. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China

Received Date: 2011-10-25

Rev Recd Date: 2011-12-23

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Abstract: Objective To review the latest research progress of the solid lipid nano-particle. Methods Domestic and foreign representative literature information of solid lipid nano-particles and its application were analyzed and summarized. Results Many kinds of preparation methods of solid lipid nano-particle had advantages and disadvantages, the high pressure homogenization technique and micro-emulsion method were recommended. Adjusting preparation parameters could be adjusted drug encapsulation efficiency and drug delivering curve. Conclusion Solid lipid nano-particle was a kind of excellent performance, which could be promising new drug delivery system.

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Reference (21)

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Preparation and application of solid lipid nano-particles

doi: 10.3969/j.issn.1006-0111.2012.05.003

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通讯作者: 陈斌, [email protected]

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