Progress in pulsatile drug delivery system

LI Ying; LU Yang; DU Shou-ying; MA Yong; XU Pan

doi:10.3969/j.issn.1006-0111.2012.05.002

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Volume 30 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2012 > 30(5): 326-330,343

LI Ying, LU Yang, DU Shou-ying, MA Yong, XU Pan. Progress in pulsatile drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 326-330,343. doi: 10.3969/j.issn.1006-0111.2012.05.002

Citation:

LI Ying, LU Yang, DU Shou-ying, MA Yong, XU Pan. Progress in pulsatile drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 326-330,343. doi: 10.3969/j.issn.1006-0111.2012.05.002

Progress in pulsatile drug delivery system

doi: 10.3969/j.issn.1006-0111.2012.05.002

1.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
2.
Medical Insurance Research Council of China, Beijing 100716, China

Received Date: 2012-02-01
Rev Recd Date: 2012-03-01

Abstract

Pulsatile drug delivery system developed quickly with the further study of chronobiology and chronopharmacology, which controled drug release and dosage by the method of formulation, and could coordinate the change of physiological rhythm, furthermore ensure efficacy and reduce adverse reaction. The characteristics and drug release mechanism of pulsatile drug delivery system were introduced and the clinical applications of pulsatile drug delivery system in recent years were discussed.
- pulsatile drug delivery system,
- drug release mechanism,
- biological rhythm,
- dosage form,
- chronopharmacology

References

[1]	廖华.缓控释制剂简介[J].湖北中医杂志,2008,30(12):51.
[2]	Rane AB, Gattani SG, Kadam VD,et al. Formulation and evaluation of press coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers[J].Chem Pharm Bull (Tokyo),2009,57(11):1213.
[3]	杨金有.生物节律与合理用药[J].中国实用医药,2010,5(5):241.
[4]	袁源,刘保安.昼夜节律与肿瘤的相关研究进展[J].现代生物医学进展, 2009,9(5):976
[5]	Smolensky MH, Peppas NA. Chronobiology, drug delivery, and chronotherapeutics[J].Adv Drug Deliv Rev,2007,59(9-10):828.
[6]	Youan BB.Chronopharmaceutics:gimmick or clinically relevant approach to drug delivery? [J].J Control Release,2004,98(3):337.
[7]	丛绍强,王延文,王智亮.中药时辰药理学的研究进展[J].泰山卫生,2005,29(1):11.
[8]	潘颖,杨劫.脉冲释药系统[J].河北医药,2005,27(11):862.
[9]	Lin HL, Lin SY, Lin YK, et al. Release characteristics and in vitro-in vivo correlation of pulsatile pattern for a pulsatile drug delivery system activated by membrane rupture via osmotic pressure and swelling[J]. Eur J Pharm Biopharm, 2008,70(1):289.
[10]	Fan TY, Wei SL, Yan WW, et al.An investigation of pulsatile release tablets with ethylcellulose and Eudragitl as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets[J].J Control Release,2001,77(3):245.
[11]	Gao C, Huang J, Jiao Y, et al. In vitro release and in vivo absorption in beagle dogs of meloxicam from Eudragit FS 30 D-coated pellets[J]. Int J Pharm, 2006,322(1-2):104.
[12]	许建辰.微囊化技术用于脉冲给药系统的研究[D].天津大学,2005.
[13]	He W, Du Q, Cao DY, et al. Study on colon-specific pectin/ethylcellulose film-coated 5-fluorouracil pellets in rats[J]. Int J Pharm,2008,348(1-2):35.
[14]	侯世祥,杜守颖,夏新华,等.现代中药制剂设计理论与实践[M].北京:人民卫生出版社,2010.620.
[15]	Efentakis M, Koligliati S, Vlachou M.Design and evaluation of a dry coated drug delivery system with an impermeable cup, swellable top layer and pulsatile release[J].Int J Pharm,2006,311 (1-2):147.
[16]	谢燕,马越鸣,李国文.口服脉冲控释给药系统的释药机制及其应用[J].中国医药工业杂志,2011,42(1):60.
[17]	施祥杰,周建平.胃内滞留释药系统的研究新进展[J].药学进展,2010,34(2):55.
[18]	Miyazaki Y, Ogihara K, Yakou S, et al. In vitro and in vivo evaluation of mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate[J].Int J Pharm,2003,258 (1-2):21.
[19]	邹豪,孔令山,谢明萱.漂浮型脉冲释放胶囊的人体内γ-闪烁扫描示踪研究[J].中国医药工业杂志,2004,35(12):724.
[20]	唐宇,罗杰英,王文苹.胃内膨胀型制剂的研究进展[J].中国新药杂志,2009,18(14):1304.
[21]	Park K, Chen J, Park H. Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties[P].US, 6271278, 2001-08-07.
[22]	郭涛,周俭平,隋因,等.硫酸沙丁胺醇脉冲片的制备及体外释放度研究[J].中国药学杂志,2000,35(6):388.
[23]	杨正管,朱家壁,刘锡钓.茶碱脉冲式控释片的研制[J].中国医院药学杂志,1998,18(11):483.
[24]	匡玉霞,刘生友.心血管疾病的昼夜节律与时辰给药[J].中国药师,2010,13(10):1514.
[25]	孙学惠,郭涛,宋洪涛,等.单硝酸异山梨酯定时脉冲控释片的研究[J].解放军药学学报,2005,21(4):258.
[26]	吴芳,张志荣,何伟玲,等.磷酸川芎嗪脉冲塞胶囊的制备与体外释放[J]. 药学学报,2002,37(9):733.
[27]	陈燕忠,岗艳云,金志忠,等.法莫替丁脉冲控释胶囊剂的研究[J].中国药科大学学报,1997,28(3):150.
[28]	曹赛宏.浅谈糖皮质激素的合理应用[J].安庆医学,2005,26(1):6.
[29]	郭涛,郑春丽,宋洪涛,等.双氯芬酸钠脉冲控释微丸的研究[J].药学学报,2003,38(9):707.
[30]	郑春丽,郭涛,宋洪涛,等.双氯芬酸钠脉冲控释微丸的制备与体外释放影响因素的研究[J].中国药学杂志,2003,38(2):111.
[31]	安娜.栓塞控制型盐酸维拉帕米双脉冲胶囊的研制[D].河北医科大学,2010.
[32]	胡文静,张良珂,刘静.含果胶盖塞型脉冲胶囊的制备及体外释放研究[J]. 中国药学杂志,2009,44(9):685.
[33]	刘伟芬,张会丽.硝苯地平脉冲释放微丸的试制[J].中国中医药现代远程教育,2010,8(14):201.
[34]	梁雪丹,郑颖,范田园.丹参酮ⅡA脉冲微丸的制备与体外质量评价[J]. 北京大学学报,2010,42(5):559.
[35]	屈勇,张怡,林宁.丹参口服脉冲控释片的制备及体外释药研究[J].湖北中医学院学报,2010,12(6):24.
[36]	逄凤娟,邹梅娟,刘国良,等.盐酸伪麻黄碱脉冲小片包衣液处方优化[J].沈阳药科大学学报,2009,26(3):170.

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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Progress in pulsatile drug delivery system

1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China

2. Medical Insurance Research Council of China, Beijing 100716, China

Received Date: 2012-02-01

Rev Recd Date: 2012-03-01

Key words:

Abstract: Pulsatile drug delivery system developed quickly with the further study of chronobiology and chronopharmacology, which controled drug release and dosage by the method of formulation, and could coordinate the change of physiological rhythm, furthermore ensure efficacy and reduce adverse reaction. The characteristics and drug release mechanism of pulsatile drug delivery system were introduced and the clinical applications of pulsatile drug delivery system in recent years were discussed.

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Reference (36)

[1]	廖华.缓控释制剂简介[J].湖北中医杂志,2008,30(12):51.
[2]	Rane AB, Gattani SG, Kadam VD,et al. Formulation and evaluation of press coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers[J].Chem Pharm Bull (Tokyo),2009,57(11):1213.
[3]	杨金有.生物节律与合理用药[J].中国实用医药,2010,5(5):241.
[4]	袁源,刘保安.昼夜节律与肿瘤的相关研究进展[J].现代生物医学进展, 2009,9(5):976
[5]	Smolensky MH, Peppas NA. Chronobiology, drug delivery, and chronotherapeutics[J].Adv Drug Deliv Rev,2007,59(9-10):828.
[6]	Youan BB.Chronopharmaceutics:gimmick or clinically relevant approach to drug delivery? [J].J Control Release,2004,98(3):337.
[7]	丛绍强,王延文,王智亮.中药时辰药理学的研究进展[J].泰山卫生,2005,29(1):11.
[8]	潘颖,杨劫.脉冲释药系统[J].河北医药,2005,27(11):862.
[9]	Lin HL, Lin SY, Lin YK, et al. Release characteristics and in vitro-in vivo correlation of pulsatile pattern for a pulsatile drug delivery system activated by membrane rupture via osmotic pressure and swelling[J]. Eur J Pharm Biopharm, 2008,70(1):289.
[10]	Fan TY, Wei SL, Yan WW, et al.An investigation of pulsatile release tablets with ethylcellulose and Eudragitl as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets[J].J Control Release,2001,77(3):245.
[11]	Gao C, Huang J, Jiao Y, et al. In vitro release and in vivo absorption in beagle dogs of meloxicam from Eudragit FS 30 D-coated pellets[J]. Int J Pharm, 2006,322(1-2):104.
[12]	许建辰.微囊化技术用于脉冲给药系统的研究[D].天津大学,2005.
[13]	He W, Du Q, Cao DY, et al. Study on colon-specific pectin/ethylcellulose film-coated 5-fluorouracil pellets in rats[J]. Int J Pharm,2008,348(1-2):35.
[14]	侯世祥,杜守颖,夏新华,等.现代中药制剂设计理论与实践[M].北京:人民卫生出版社,2010.620.
[15]	Efentakis M, Koligliati S, Vlachou M.Design and evaluation of a dry coated drug delivery system with an impermeable cup, swellable top layer and pulsatile release[J].Int J Pharm,2006,311 (1-2):147.
[16]	谢燕,马越鸣,李国文.口服脉冲控释给药系统的释药机制及其应用[J].中国医药工业杂志,2011,42(1):60.
[17]	施祥杰,周建平.胃内滞留释药系统的研究新进展[J].药学进展,2010,34(2):55.
[18]	Miyazaki Y, Ogihara K, Yakou S, et al. In vitro and in vivo evaluation of mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate[J].Int J Pharm,2003,258 (1-2):21.
[19]	邹豪,孔令山,谢明萱.漂浮型脉冲释放胶囊的人体内γ-闪烁扫描示踪研究[J].中国医药工业杂志,2004,35(12):724.
[20]	唐宇,罗杰英,王文苹.胃内膨胀型制剂的研究进展[J].中国新药杂志,2009,18(14):1304.
[21]	Park K, Chen J, Park H. Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties[P].US, 6271278, 2001-08-07.
[22]	郭涛,周俭平,隋因,等.硫酸沙丁胺醇脉冲片的制备及体外释放度研究[J].中国药学杂志,2000,35(6):388.
[23]	杨正管,朱家壁,刘锡钓.茶碱脉冲式控释片的研制[J].中国医院药学杂志,1998,18(11):483.
[24]	匡玉霞,刘生友.心血管疾病的昼夜节律与时辰给药[J].中国药师,2010,13(10):1514.
[25]	孙学惠,郭涛,宋洪涛,等.单硝酸异山梨酯定时脉冲控释片的研究[J].解放军药学学报,2005,21(4):258.
[26]	吴芳,张志荣,何伟玲,等.磷酸川芎嗪脉冲塞胶囊的制备与体外释放[J]. 药学学报,2002,37(9):733.
[27]	陈燕忠,岗艳云,金志忠,等.法莫替丁脉冲控释胶囊剂的研究[J].中国药科大学学报,1997,28(3):150.
[28]	曹赛宏.浅谈糖皮质激素的合理应用[J].安庆医学,2005,26(1):6.
[29]	郭涛,郑春丽,宋洪涛,等.双氯芬酸钠脉冲控释微丸的研究[J].药学学报,2003,38(9):707.
[30]	郑春丽,郭涛,宋洪涛,等.双氯芬酸钠脉冲控释微丸的制备与体外释放影响因素的研究[J].中国药学杂志,2003,38(2):111.
[31]	安娜.栓塞控制型盐酸维拉帕米双脉冲胶囊的研制[D].河北医科大学,2010.
[32]	胡文静,张良珂,刘静.含果胶盖塞型脉冲胶囊的制备及体外释放研究[J]. 中国药学杂志,2009,44(9):685.
[33]	刘伟芬,张会丽.硝苯地平脉冲释放微丸的试制[J].中国中医药现代远程教育,2010,8(14):201.
[34]	梁雪丹,郑颖,范田园.丹参酮ⅡA脉冲微丸的制备与体外质量评价[J]. 北京大学学报,2010,42(5):559.
[35]	屈勇,张怡,林宁.丹参口服脉冲控释片的制备及体外释药研究[J].湖北中医学院学报,2010,12(6):24.
[36]	逄凤娟,邹梅娟,刘国良,等.盐酸伪麻黄碱脉冲小片包衣液处方优化[J].沈阳药科大学学报,2009,26(3):170.

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Progress in pulsatile drug delivery system

doi: 10.3969/j.issn.1006-0111.2012.05.002

Abstract

References

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通讯作者: 陈斌, [email protected]

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