Application of microbial transformation in natural products research

LIU Qing-xin; LI Hui-liang; LIU Run-hui

doi:10.3969/j.issn.1006-0111.2012.05.001

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

With the continuous development of biotechnology technology, microbial transformation gradually was applied to the study of natural products. The specific effective reactions, mild reaction conditions and high yield of the microbial transformation were outlined in this paper. The applications were reviewed in the microbial transformation of natural products in recent five years, especially in anthraquinones, flavonoids, terpenoids, steroids, alkaloids and glycosides. The developments of microbial transformation were prospected.

Application of microbial transformation in natural products research

1. Department of Pharmacy, Fujian Traditional Chinese Medicine University, Fuzhou 350108, China

2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-02-02

Rev Recd Date: 2012-03-26

Key words:

Abstract: With the continuous development of biotechnology technology, microbial transformation gradually was applied to the study of natural products. The specific effective reactions, mild reaction conditions and high yield of the microbial transformation were outlined in this paper. The applications were reviewed in the microbial transformation of natural products in recent five years, especially in anthraquinones, flavonoids, terpenoids, steroids, alkaloids and glycosides. The developments of microbial transformation were prospected.

HTML

Reference (31)

[1]	陈代杰. 生物转化与药物开发[J]. 医药化工, 2005,9(9):1.
[2]	郭继强, 朱殿生, 谭慧,等. 假单胞菌转化喜树碱的初步研究[J]. 食品科技, 2010, 35(1):42.
[3]	Peterson D, Murray H,Eppstein S. et al, Microbiological Transformations of Steroids. 1 I. Introduction of Oxygen at Carbon-11 of Progesterone[J]. Journal of the American Chemical Society, 1952, 74 (23):5933.
[4]	吴梧桐, 丁锡申, 刘景晶. 基因工程药物:基础与临床[M].北京:人民卫生出版社, 1996:183.
[5]	张薇, 占纪勋, 陈英杰, 等. 刺囊毛霉对三种大黄游离蒽醌的生物转化研究[J]. 中国天然药物, 2003, 1(4):219.
[6]	戴万生, 赵荣华. 发酵法对大黄蒽醌类成分含量的影响[J]. 云南中医中药杂志, 2005, 26(1):38.
[7]	Jakubowicz-Gil J, Paduch R, Gawron A, et al. The effect of heat shock, cisplatin, etoposide and quercetin on Hsp27 expression in human normal and tumour cells[J]. Folia Histochem Cytobiol, 2002, 40(1):31.
[8]	王园园, 余伯阳, 李里, 等. 灰色链霉菌对芦丁的生物转化及产物的抗氧化活性[J]. 中国天然药物, 2006, 4(1):66.
[9]	徐萌萌, 沈竞, 徐春, 等. 槐米固态发酵提高槲皮素含量的研究[J]. 时珍国医国药, 2008, 19(3):704.
[10]	高陪, 苏建, 沈竞, 等. 微生物发酵转化芦丁制备槲皮素的研究[J]. 四川大学学报(自然科学版), 2010, 47(6):1429.
[11]	杨莉萍, 崔志超, 高芳, 等. 融粘帚霉对葛根素的生物转化研究[J]. 工业微生物, 2011, 41(2):47.
[12]	汪红, 高陪, 廖勇, 等. 微生物发酵转化黄芩苷生成黄芩素的研究[J]. 四川大学学报(自然科学版), 2009, 46(3):795.
[13]	陈有根, 余伯阳. 微生物转化青蒿素为9α-羟基青蒿素的条件优化[J]. 药物生物技术, 2001, 8(2):90.
[14]	占纪勋, 魏秋芬, 单成启, 等. 四个青蒿素生物转化产物抗体外培养恶性疟原虫滑陛研究[J]. 中国热带医学, 2003, 3(1):17.
[15]	Zhan JX, Guo HZ, Han J, et al. Biotransformation of artemisinin by fermentation of Rhizopus chinensis and Curminghamell elegans[J]. Chinese Traditional Herbal Drugs, 2002, 33 (10):869.
[16]	和朝军, 孙华, 李鹏举, 等. 新月弯孢霉KA-9l对甘草次酸的转化研究[J]. 药物生物技术, 2011, 18(3):238.
[17]	马晶, 辛秀兰, 张薇, 等. 刺囊毛霉对甘草次酸的微生物转化研究[J]. 北京化工大学学报,2008,35(1):79.
[18]	马晶, 辛秀兰, 袁其朋, 等. HPLC法测定刺囊毛霉微生物转化甘草次酸的主产物含量[J]. 微生物学通报, 2008, 35(10):l664.
[19]	占纪勋, 张元兴, 宁黎丽, 等. 铜绿假单孢菌AS1.860对紫杉醇的微生物转化[J]. 应用与环境生物学报, 2003, 9(4):429.
[20]	李合平, 许东升, 徐海伟, 等. 微生物转化法制备脱水穿心莲内酯[J]. 中国药科大学学报, 2008, 39(5):479.
[21]	杨若林, 郑桂兰, 张荣庆. 黄柏酮微生物转化研究[J]. 中草药, 2007, 38 (10):1471.
[22]	李于善, 贺艳. 白首乌甾苷元C11α-羟基化的两种微生物转化[J]. 化学与生物工程, 2008, 25(7):48.
[23]	姜绍通, 赵俊平, 杨英, 等. 两相系统发酵转化植物甾醇为雄烯二酮的研究[J]. 食品与发酵工业, 2008, 34(6):46.
[24]	郝雪秦, 许激扬, 陈代杰, 等. 利用双水相系统转化雄甾-1, 4-二烯-3, 17-二酮的研究[J]. 药物生物技术, 2003, 10(3):169.
[25]	朱殿生, 张彧, 于营, 等. 喜树碱生物转化优良菌株的筛选及其转化条件初步研究[J]. 大连轻工业学院学报, 2007, 26(1):18.
[26]	Lv YF, Chen KY, Li HL, et al. Biotransformation of vermitaline by Cunninghamella echinulata[J]. Helvetica Chimica Acta,2008, 91:819.
[27]	金艳, 尹成日, 金恩华. 微生物转化人参皂苷Rbl为C-K的研究[J]. 人参研究, 2010, (4):7.
[28]	白龙律, 臧蕴霞, 尹成日. 微生物转化人参皂苷Rb1为Rg3的研究[J]. 延边大学学报(自然科学版), 2009, 35(2):141.
[29]	金艳, 金香梅, 尹成日. 微生物转化人参皂苷Rbl为稀有皂苷F2[J]. 延边大学农学学报, 2011, 33(2):112.
[30]	田天丽, 沈竞, 徐萌萌, 等. 虎杖中虎杖苷的微生物发酵转化研究[J]. 四川大学学报(自然科学版), 2008, 45(2):437.
[31]	王永宏, 苏建, 王建芳, 等. 栀子中京尼平苷的微生物转化研究[J]. 时珍国医国药, 2007, 18(12):3003.

Message Board

Application of microbial transformation in natural products research

doi: 10.3969/j.issn.1006-0111.2012.05.001

Abstract

References

Proportional views

通讯作者: 陈斌, [email protected]

Article Metrics

Related

Proportional views