2008 Vol. 26, No. 6
Display Method:
2008, (6): 417-419,437.
Abstract:
New progress of matrix tablets and release mechanisms were reviewed.The release characteristics and mechanisms for the matrix of sustained and controlled release tablets were dicussed.And new supplementary material's application in matrix tablet was introduced.A prospect for the matrix of sustained and controlled release preparations was made.
New progress of matrix tablets and release mechanisms were reviewed.The release characteristics and mechanisms for the matrix of sustained and controlled release tablets were dicussed.And new supplementary material's application in matrix tablet was introduced.A prospect for the matrix of sustained and controlled release preparations was made.
2008, (6): 422-426.
Abstract:
Objective: To investigate the protective effect of Yixin oral liquid(YOL)preconditoning on acute myocardial ischemia in rats. Methods: The model of acute myocardial ischemia was established on rats by left coronary artery ligation,then the rats were divided into 7 groups randomly:sham operation group,Model group,Diltiazem hydrochloride group,Fufang Danshen Dripping Pills group(FD) and various concentration of YOL groups(high,medium and low doses).The change of J point of ECG,the left ventricular function (LVSP,LVEDP,±dp/dtmax),the superoxide dismutase(SOD)and malonaldehyde(MDA)contents in serum,and the pathologic structure of ischemic rats were observed. Results: The YOL preconditoning could obviously antagonize J point raise and deterioration of left ventricular function compared with the model group(P<0.05),in which the high and medium dose groups with YOL are better;and there were no significant difference between FD group and the high and medium-dose with YOL group.The high and medium dose group with YOL raised SOD level and decreased MDA level in serum,and also ameliorated myocardial pathologic structure changes in acute ischemia rat. Conclusion: YOL preconditioning contributes to protective effect on acute myocardial ischemia in rats.
Objective: To investigate the protective effect of Yixin oral liquid(YOL)preconditoning on acute myocardial ischemia in rats. Methods: The model of acute myocardial ischemia was established on rats by left coronary artery ligation,then the rats were divided into 7 groups randomly:sham operation group,Model group,Diltiazem hydrochloride group,Fufang Danshen Dripping Pills group(FD) and various concentration of YOL groups(high,medium and low doses).The change of J point of ECG,the left ventricular function (LVSP,LVEDP,±dp/dtmax),the superoxide dismutase(SOD)and malonaldehyde(MDA)contents in serum,and the pathologic structure of ischemic rats were observed. Results: The YOL preconditoning could obviously antagonize J point raise and deterioration of left ventricular function compared with the model group(P<0.05),in which the high and medium dose groups with YOL are better;and there were no significant difference between FD group and the high and medium-dose with YOL group.The high and medium dose group with YOL raised SOD level and decreased MDA level in serum,and also ameliorated myocardial pathologic structure changes in acute ischemia rat. Conclusion: YOL preconditioning contributes to protective effect on acute myocardial ischemia in rats.
2008, (6): 427-429.
Abstract:
Objective: To establish a convenient and feasible animal model of vestibular dysfunction for pharmacodynamic study in mice. Methods: Both inner ears of the animals were intratympanically injected with 100 mg/mL solution of arsanilic acid for 0.05 mL. 3 days later,vestibular function was assessed by air righting reflex and contact righting reflex,as well as the head tilt and swimming behavior. Results: Correct landings rates of air righting reflex were decreased;time of contact righting reflex was prolonged;scores of head tilt and swimming behavior were higher than control. Conclusion: It is a convenient and feasible model of experimental vestibular dysfunction with injections of arsanilic acid in the inner ears of mice for research on pharmacodynamics of prophylactic drug for motion sickness and vertigo.
Objective: To establish a convenient and feasible animal model of vestibular dysfunction for pharmacodynamic study in mice. Methods: Both inner ears of the animals were intratympanically injected with 100 mg/mL solution of arsanilic acid for 0.05 mL. 3 days later,vestibular function was assessed by air righting reflex and contact righting reflex,as well as the head tilt and swimming behavior. Results: Correct landings rates of air righting reflex were decreased;time of contact righting reflex was prolonged;scores of head tilt and swimming behavior were higher than control. Conclusion: It is a convenient and feasible model of experimental vestibular dysfunction with injections of arsanilic acid in the inner ears of mice for research on pharmacodynamics of prophylactic drug for motion sickness and vertigo.
2008, (6): 428-440.
Abstract:
Objective: To establish an enriching technic process of total flavones from Herba Oxytropis Falcatae by macroporous resin. Methods: Zirconium oxychloride（ZrOCl2）chromatometry was used to determine the content of total flavones in samples.Dynamic state adsorbability,concentration and volume of adsorption stripping solvent,and the re-utilization of D-101 macroporous resin were studied. Results: The content of total flavones in enrichment is 26%,which was nearly five times of that before enriched. Conclusion: Chromatometry with zirconium oxychloride as developer is simple and credible.D-101 macroporous resin showed better adsorbability of flavones from the aqueous extract of Herba Oxytropis Falcatae with high re-availability,and 60%alcohol could be used as adsorption stripping solvent because it works quickly and efficiently.
Objective: To establish an enriching technic process of total flavones from Herba Oxytropis Falcatae by macroporous resin. Methods: Zirconium oxychloride（ZrOCl2）chromatometry was used to determine the content of total flavones in samples.Dynamic state adsorbability,concentration and volume of adsorption stripping solvent,and the re-utilization of D-101 macroporous resin were studied. Results: The content of total flavones in enrichment is 26%,which was nearly five times of that before enriched. Conclusion: Chromatometry with zirconium oxychloride as developer is simple and credible.D-101 macroporous resin showed better adsorbability of flavones from the aqueous extract of Herba Oxytropis Falcatae with high re-availability,and 60%alcohol could be used as adsorption stripping solvent because it works quickly and efficiently.
2008, (6): 430-431.
Abstract:
Objective: To investigate the antifatigue and hypoxia-tolerance effect of Wuzi Yanzong Wan. Methods: Each group of mice were trained into doing a weight-loaded swimming until they were exhausted,and the time span was recorded as the sign of physi- cal endurance. Results: Wuzi Yanzong Wan could significantly prolong the time span of weight-loaded swimming and Hypoxia-tolerance time in mice,and it also has immunological enhancement function. Conclusion: Wuzi Yanzong Wan is a promising health-care traditional, because of its antifatigue and hypoxia-tolerance effect.
Objective: To investigate the antifatigue and hypoxia-tolerance effect of Wuzi Yanzong Wan. Methods: Each group of mice were trained into doing a weight-loaded swimming until they were exhausted,and the time span was recorded as the sign of physi- cal endurance. Results: Wuzi Yanzong Wan could significantly prolong the time span of weight-loaded swimming and Hypoxia-tolerance time in mice,and it also has immunological enhancement function. Conclusion: Wuzi Yanzong Wan is a promising health-care traditional, because of its antifatigue and hypoxia-tolerance effect.
2008, (6): 432-434,456.
Abstract:
Objective: To find a new way of improving the quality of TCM,blendings of crude Epimedium Brevicornum from various sources were studied according to their Fingerprints. Methods: Systematic optimization was adopted to determine the mixing ratio of different kinds of non-genuine crude drugs in order to maximize the similarity,which is based on the cosine value between the fingerprints of genuine and non-genuine crude drugs respectively.Fingerprints data were collected after the blending. Results: The similarity of drugs was improved evidently,and it was in accordance with the calculation result. Conclusion: Quality improvement of TCM can be made by blending.Optimized blending of crude drugs might be an efficient method in making full use of the relatively inadequate TCM resources.
Objective: To find a new way of improving the quality of TCM,blendings of crude Epimedium Brevicornum from various sources were studied according to their Fingerprints. Methods: Systematic optimization was adopted to determine the mixing ratio of different kinds of non-genuine crude drugs in order to maximize the similarity,which is based on the cosine value between the fingerprints of genuine and non-genuine crude drugs respectively.Fingerprints data were collected after the blending. Results: The similarity of drugs was improved evidently,and it was in accordance with the calculation result. Conclusion: Quality improvement of TCM can be made by blending.Optimized blending of crude drugs might be an efficient method in making full use of the relatively inadequate TCM resources.
2008, (6): 435-437.
Abstract:
Objective: To develop an HPLC quantitative method for the determination of baicalin in Xiaoer Runfei Oral liquid. Methods: HPLC system consisted an Agilent C18column（ZORBAX Eclipse XDB-C18,4.6 mm×150 mm,5μm）and a mixture of methanol-water-phosphoric acid（38:62:0.5）as mobile phase.The flow rate was 1.0 mL/min and was monitored at 278 nm. Results: The retention time of baicalin was 20.6 min.The regress equation for baicalin was Y=0.060 47X+1.131,r=0.999 9,and the linear range was 62.84～314.2μg/mL.The average recovery of baicalin was（n=6）103.3%,RSD 0.43%. Conclusion: The method was sensitive,time-saving and accurate.
Objective: To develop an HPLC quantitative method for the determination of baicalin in Xiaoer Runfei Oral liquid. Methods: HPLC system consisted an Agilent C18column（ZORBAX Eclipse XDB-C18,4.6 mm×150 mm,5μm）and a mixture of methanol-water-phosphoric acid（38:62:0.5）as mobile phase.The flow rate was 1.0 mL/min and was monitored at 278 nm. Results: The retention time of baicalin was 20.6 min.The regress equation for baicalin was Y=0.060 47X+1.131,r=0.999 9,and the linear range was 62.84～314.2μg/mL.The average recovery of baicalin was（n=6）103.3%,RSD 0.43%. Conclusion: The method was sensitive,time-saving and accurate.
2008, (6): 441-443.
Abstract:
Objective: To study the chemical constituents of the branches of Daphne genkwa Sieb.et Zucc. Methods: Column chromatography on Silica gel and Sephadex LH-20,and recrystallization were used for the isolation and purification of the constituents. The structures were identified on the basis of spectral analysis and chemical evidences. Results: From the crude CHCl3 fraction of the EtOH extract of the branches of D.genkwa,6 coumarins were isolated and identified,which were umbelliferone（1）,daphnoretin （2）,daphnetin（3）,edgeworthin（4）,edgeworin（5）,and umbelliferone-7-O-β-D-glycoside（6）. Conclusion: ICompounds 3～6 were isolated and identified from the branches of Daphne genkwa for the first time.
Objective: To study the chemical constituents of the branches of Daphne genkwa Sieb.et Zucc. Methods: Column chromatography on Silica gel and Sephadex LH-20,and recrystallization were used for the isolation and purification of the constituents. The structures were identified on the basis of spectral analysis and chemical evidences. Results: From the crude CHCl3 fraction of the EtOH extract of the branches of D.genkwa,6 coumarins were isolated and identified,which were umbelliferone（1）,daphnoretin （2）,daphnetin（3）,edgeworthin（4）,edgeworin（5）,and umbelliferone-7-O-β-D-glycoside（6）. Conclusion: ICompounds 3～6 were isolated and identified from the branches of Daphne genkwa for the first time.
2008, (6): 444-446,467.
Abstract:
Objective: To synthesize new pyridazinone derivatives substituted by different amino groups. Methods: Eight target compounds were designed and synthesized by inletting different substituted amino groups connecting through the acetyl fragment.All of them were confirmed by 1 H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported for the first time.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggregative activity to a certain extent.Compounds（1）,（3）and（8）have better activeties;compound （3）showed a 6 times higher activity than that of MCI-154. Conclusion: Inletting different substituted amino groups can enhance the antiplatelet aggregation activity of the compounds.
Objective: To synthesize new pyridazinone derivatives substituted by different amino groups. Methods: Eight target compounds were designed and synthesized by inletting different substituted amino groups connecting through the acetyl fragment.All of them were confirmed by 1 H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported for the first time.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggregative activity to a certain extent.Compounds（1）,（3）and（8）have better activeties;compound （3）showed a 6 times higher activity than that of MCI-154. Conclusion: Inletting different substituted amino groups can enhance the antiplatelet aggregation activity of the compounds.
2008, (6): 447-449.
Abstract:
Objective: To optimize the synthesis of replaced imidazole. Methods: Orthogonal experimental design was used and the influence of temperature,reactant ratio and solvent on the yield were investigated. Results: Reactant ratio was more important than the others.The yield was improved from less than 10%to 42.5%. Conclusion: The optimal preparation procedure is stable and available for industrial production.
Objective: To optimize the synthesis of replaced imidazole. Methods: Orthogonal experimental design was used and the influence of temperature,reactant ratio and solvent on the yield were investigated. Results: Reactant ratio was more important than the others.The yield was improved from less than 10%to 42.5%. Conclusion: The optimal preparation procedure is stable and available for industrial production.
2008, (6): 455-456.
Abstract:
Objective: To set up a method for determining the density of solid medicines.Method:Based on the definition of density, a mathematical formula for calculating the density of solid medicine was deducted. Results: By means of calculating with the mathematical formula,it is able to determine the density of some solid medicines. Conclusion: This method is suitable to directly determine the density of some solid medicines and packaging materials for medicine such as PVC,and is unnecessary to use other density meters.
Objective: To set up a method for determining the density of solid medicines.Method:Based on the definition of density, a mathematical formula for calculating the density of solid medicine was deducted. Results: By means of calculating with the mathematical formula,it is able to determine the density of some solid medicines. Conclusion: This method is suitable to directly determine the density of some solid medicines and packaging materials for medicine such as PVC,and is unnecessary to use other density meters.
2008, (6): 459-461.
Abstract:
Objective: To facilitate the doctors'standardized writing of prescriptions and choosing medicines and instructing the pharmacists'prescriptions accurately.Then we can reduce malpractices and ensure the safety and utility of medication. Methods: According to the new edition of prescription management regulations,we investigated 5 018 presciptions of outpatient clinic teaditional Chinese medicine prescriptions from 2007 to 2008 in our hospital.The standardization of writing and herbal medicines in a prescription of these prescriptions were analyzed. Results: We found that the percent of age prescriptions of nonstandardization of writing is 43.12%, including nonstandardization of prolegomena,nonstandardization of revision,nonstandardization of drug names,nonstandardization of annotation and units. Conclusion: The hospital managers should establish a wholesome prescription management system and take related measures to enhance it.The doctor should strengthen the learning of prescription management regulations.The pharmacist should improve their ability to check prescriptions and to find out problems while they are working.
Objective: To facilitate the doctors'standardized writing of prescriptions and choosing medicines and instructing the pharmacists'prescriptions accurately.Then we can reduce malpractices and ensure the safety and utility of medication. Methods: According to the new edition of prescription management regulations,we investigated 5 018 presciptions of outpatient clinic teaditional Chinese medicine prescriptions from 2007 to 2008 in our hospital.The standardization of writing and herbal medicines in a prescription of these prescriptions were analyzed. Results: We found that the percent of age prescriptions of nonstandardization of writing is 43.12%, including nonstandardization of prolegomena,nonstandardization of revision,nonstandardization of drug names,nonstandardization of annotation and units. Conclusion: The hospital managers should establish a wholesome prescription management system and take related measures to enhance it.The doctor should strengthen the learning of prescription management regulations.The pharmacist should improve their ability to check prescriptions and to find out problems while they are working.
2008, (6): 472-475.
Abstract:
Objective: To analyze the characteristics of adverse drug reaction and promote rational clinical drug use. Methods: 550 ADR reports of our hospital during 1.1.2007 and 8.1.2008 has been collected.The categories and administration route of drugs that have caused ADR were statistically analyzed as well as the damaged organs caused by ADR and ADR patients'adverse drug reaction history. Results: Among the total 550 reports,the percentage of middle aged and elderly patients was 28.0%;the percentage of ADR caused by antibiotics was 61.64%;and that of ADR caused by intravenous drip was 70.0%.The major clinical manifestation of ADR were tetter,dizziness,headache and gastrointestinal reaction. Conclusion: based on the characteristics and discipline of ADR, the adapted symptoms of drugs should be strictly controlled,and supervision on drug use should be strengthened.Detection and management on ADR should be target-oriented taken to minimize the occurrence of ADR.
Objective: To analyze the characteristics of adverse drug reaction and promote rational clinical drug use. Methods: 550 ADR reports of our hospital during 1.1.2007 and 8.1.2008 has been collected.The categories and administration route of drugs that have caused ADR were statistically analyzed as well as the damaged organs caused by ADR and ADR patients'adverse drug reaction history. Results: Among the total 550 reports,the percentage of middle aged and elderly patients was 28.0%;the percentage of ADR caused by antibiotics was 61.64%;and that of ADR caused by intravenous drip was 70.0%.The major clinical manifestation of ADR were tetter,dizziness,headache and gastrointestinal reaction. Conclusion: based on the characteristics and discipline of ADR, the adapted symptoms of drugs should be strictly controlled,and supervision on drug use should be strengthened.Detection and management on ADR should be target-oriented taken to minimize the occurrence of ADR.
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