2007 Vol. 25, No. 2
Display Method:
2007, (2): 78-79,87.
Abstract:
Objective: To compare the effect of four stimulator to induce motion sickness in rats. Methods: 40 male SD rats were di-vided into four groups randomly.The induced motion sickness was determined by the assay of kaolin intake 2 days before and 2 days after rotational stimulation.GroupⅠwere stimulated in a rotator with ahernately variable speed for 1h,which were rotated clockwise around a horizontal axis at an angular acceleration of 18°/s2 until the angular velocity reached 120°/s.Then the device was decelerated at an angu-lar acceleration of 48°/s2 until rotation stopped.GroupⅡwere treated identically except that they were rotated for 1.5h.GroupⅢwere stimulated with alternately variable speed for 1h,which rotated clockwise around a horizontal axis at an angular acceleration of 48°/s2 un-til the angular velocity reached 120°/s.Then the device was decelerated at the same rate until rotation stopped.GroupⅣwere rotated at 120°/s clockwise around a horizontal axis. Results: Among the four groups,the difference of kaolin intake before and after rotation of groupⅠ,groupⅡand groupⅢwere significantly more than that of control group(groupⅡP＜0.01,groupⅠand groupⅢP＜0.05).The difference of kaolin intake before and after rotation of groupⅡwas more than others(P＜0.01). Conclusion: The rotational stimulation of groupⅠ,groupⅡand groupⅢcan induce motion sickness in rats,and groupⅡwere the most effective.
Objective: To compare the effect of four stimulator to induce motion sickness in rats. Methods: 40 male SD rats were di-vided into four groups randomly.The induced motion sickness was determined by the assay of kaolin intake 2 days before and 2 days after rotational stimulation.GroupⅠwere stimulated in a rotator with ahernately variable speed for 1h,which were rotated clockwise around a horizontal axis at an angular acceleration of 18°/s2 until the angular velocity reached 120°/s.Then the device was decelerated at an angu-lar acceleration of 48°/s2 until rotation stopped.GroupⅡwere treated identically except that they were rotated for 1.5h.GroupⅢwere stimulated with alternately variable speed for 1h,which rotated clockwise around a horizontal axis at an angular acceleration of 48°/s2 un-til the angular velocity reached 120°/s.Then the device was decelerated at the same rate until rotation stopped.GroupⅣwere rotated at 120°/s clockwise around a horizontal axis. Results: Among the four groups,the difference of kaolin intake before and after rotation of groupⅠ,groupⅡand groupⅢwere significantly more than that of control group(groupⅡP＜0.01,groupⅠand groupⅢP＜0.05).The difference of kaolin intake before and after rotation of groupⅡwas more than others(P＜0.01). Conclusion: The rotational stimulation of groupⅠ,groupⅡand groupⅢcan induce motion sickness in rats,and groupⅡwere the most effective.
2007, (2): 80-81.
Abstract:
Objective: To compare the antitumor effect of complex shark cartilage with its components alone. Methods: Complex shark cartilage and its components,Chinese tranditional medicines and shark cartilage,were given ig in sarcoma S180-bearing mice,re-spectively. Results: Complex shark cartilage at dose 5.0,2.5,and 1.25g/(kg·d)had significant antitumor effects.The inhibition rates against the tumors were 80.2%～65.6%.The Chinese tranditional medicines(2.4,1.2,and 0.6g/kg)and the shark cartilage (2.6,1.3,and 0.65g/kg)at the doses which were equal to those in the complex shark cartilage had mild antitumor effects.The inhibi-tion rates against the tumor were below 30%. Conclusion: The components of complex shark cartilage have significant antitumor effect in S180-bearing mice.
Objective: To compare the antitumor effect of complex shark cartilage with its components alone. Methods: Complex shark cartilage and its components,Chinese tranditional medicines and shark cartilage,were given ig in sarcoma S180-bearing mice,re-spectively. Results: Complex shark cartilage at dose 5.0,2.5,and 1.25g/(kg·d)had significant antitumor effects.The inhibition rates against the tumors were 80.2%～65.6%.The Chinese tranditional medicines(2.4,1.2,and 0.6g/kg)and the shark cartilage (2.6,1.3,and 0.65g/kg)at the doses which were equal to those in the complex shark cartilage had mild antitumor effects.The inhibi-tion rates against the tumor were below 30%. Conclusion: The components of complex shark cartilage have significant antitumor effect in S180-bearing mice.
2007, (2): 82-84.
Abstract:
Objective: To study the water-soluble constituents from Cyclocarya paliurus(Batal)Ijinskaja Methods: The constitu-ents were isolated by reverse-phased materials,and their structures were characterized by chemical property and spectral analysis. Results: Seven compounds were isolated from the 70% ethanol extract of the leaves of Cyclocarya paliurus.Their structures were elucida-ted as kaempferol-3-O-β-D-glucuronate sodium(Ⅰ),quercetin-3-O-β-D-glucuronate sodium(Ⅱ),myricetin-3-O-β-D-glucuronate so-dium (Ⅲ),2,6-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside(Ⅳ),tryptophan(Ⅴ),gallic acid(Ⅵ)and benzoic acid (Ⅶ)respectively. Conclusion: CompoundsⅠ～Ⅵare isolated from this genus for the first time.
Objective: To study the water-soluble constituents from Cyclocarya paliurus(Batal)Ijinskaja Methods: The constitu-ents were isolated by reverse-phased materials,and their structures were characterized by chemical property and spectral analysis. Results: Seven compounds were isolated from the 70% ethanol extract of the leaves of Cyclocarya paliurus.Their structures were elucida-ted as kaempferol-3-O-β-D-glucuronate sodium(Ⅰ),quercetin-3-O-β-D-glucuronate sodium(Ⅱ),myricetin-3-O-β-D-glucuronate so-dium (Ⅲ),2,6-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside(Ⅳ),tryptophan(Ⅴ),gallic acid(Ⅵ)and benzoic acid (Ⅶ)respectively. Conclusion: CompoundsⅠ～Ⅵare isolated from this genus for the first time.
2007, (2): 85-87.
Abstract:
Objective: To survey the influence of the Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobar-bital sodium in mice. Methods: ICR mice were randomly divided into 4 equal groups(Dengzhanxixin injection group,breviscapine group,naloxone hydrochloride group and sodium chloride group),effects of drug on mice hypnosis induced by pentoharbital sodium in suprathreshold dose or hypnotic dose was observed.Effects of drugs on mice spontaneous movement and equilibrium function was also observed. Results: Comparing with the group of sodium chloride,the group of Dengzhanxixin injection,breviscapine and naloxone hydrochloride significantly prolonged the time of falling asleep,shorted the duration of hypnosis induced by pentobarbital sodium in su-prathreshold dose in mice respectively(P＜0.05),shorted vanishing period of righting reflex in the mice induced by pentobarbital sodi-um in hypnotic dose(P＜0.05 ). Conclusion: Dengzhanxixin injection and breviscapine had arousal effects on pentobarbital sodium treated mice.
Objective: To survey the influence of the Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobar-bital sodium in mice. Methods: ICR mice were randomly divided into 4 equal groups(Dengzhanxixin injection group,breviscapine group,naloxone hydrochloride group and sodium chloride group),effects of drug on mice hypnosis induced by pentoharbital sodium in suprathreshold dose or hypnotic dose was observed.Effects of drugs on mice spontaneous movement and equilibrium function was also observed. Results: Comparing with the group of sodium chloride,the group of Dengzhanxixin injection,breviscapine and naloxone hydrochloride significantly prolonged the time of falling asleep,shorted the duration of hypnosis induced by pentobarbital sodium in su-prathreshold dose in mice respectively(P＜0.05),shorted vanishing period of righting reflex in the mice induced by pentobarbital sodi-um in hypnotic dose(P＜0.05 ). Conclusion: Dengzhanxixin injection and breviscapine had arousal effects on pentobarbital sodium treated mice.
2007, (2): 88-90,93.
Abstract:
Objective: To investigate the effect of low dose of inhaled beclomethasone dipropionate(BDP)combined with asmeton on clinical symptoms,bronchial responsiveness and hypothalamic-pituitary-adrenal axis(HPAA). Methods: 96 patients with mild-mod-erate bronchial asthma were randomly divided into CA and C groups.49 subjects in group CA were treated with asmeton(2# tid)and inhaled BDP(300μg/day),47 cases in group C received inhaled BDP(600μg/day), Results: Before and 12 weeks after the treat-ment,symptom scores for group CA were(1.8±0.7)and(0.13±0.16),and those for group C were(1.9±0.9)and(0.13±0.15),which were remarkably improved in both groups(P＜0.01).Frequency of using inhaledβ2 agonist to relieve nocturnal asthmat-ic attacks in group C(5.9±1.4).was significantly greater than that in group CA(2.3±1.3),(P＜0.05).Plasma ACTH concentra-tions,basic cortisol levels and cortisol responses to ACTH before and 12 weeks after the treatment in group C were(31±11)ng/L and (20±9)ng/L,(97±53)μg/L and(84±43)μg/L,(156±78)% and(75±44)% respectively,which were decreased significant-ly after the treatment(P＜0.05).There were no such changes in group A. Conclusion: It was suggested that asmeton combined with low dose of inhaled BDP might have the same effect on relief of clinical symptoms and bronchial responsiveness,without suppression on HPAA function,comparing with relatively higher dose of inhaled BDP.
Objective: To investigate the effect of low dose of inhaled beclomethasone dipropionate(BDP)combined with asmeton on clinical symptoms,bronchial responsiveness and hypothalamic-pituitary-adrenal axis(HPAA). Methods: 96 patients with mild-mod-erate bronchial asthma were randomly divided into CA and C groups.49 subjects in group CA were treated with asmeton(2# tid)and inhaled BDP(300μg/day),47 cases in group C received inhaled BDP(600μg/day), Results: Before and 12 weeks after the treat-ment,symptom scores for group CA were(1.8±0.7)and(0.13±0.16),and those for group C were(1.9±0.9)and(0.13±0.15),which were remarkably improved in both groups(P＜0.01).Frequency of using inhaledβ2 agonist to relieve nocturnal asthmat-ic attacks in group C(5.9±1.4).was significantly greater than that in group CA(2.3±1.3),(P＜0.05).Plasma ACTH concentra-tions,basic cortisol levels and cortisol responses to ACTH before and 12 weeks after the treatment in group C were(31±11)ng/L and (20±9)ng/L,(97±53)μg/L and(84±43)μg/L,(156±78)% and(75±44)% respectively,which were decreased significant-ly after the treatment(P＜0.05).There were no such changes in group A. Conclusion: It was suggested that asmeton combined with low dose of inhaled BDP might have the same effect on relief of clinical symptoms and bronchial responsiveness,without suppression on HPAA function,comparing with relatively higher dose of inhaled BDP.
2007, (2): 91-93.
Abstract:
Objective: To prepare the placenta polypeptide injection and establish the standard of quality control and to evaluate the therapeutic effect on white lesion of vulva. Methods: The placenta polypeptide injection was made from healthy human placenta by the method of thaw and ultrafiltration.The content of polypeptide was determined by Lowry-method. Results: The linear relationship of placenta polypeptide was found from 20μg/mL to 100μg/mL.The average recovery of polypeptide was 100.16%,99.25% and 98.59%,respectively.RSD was 1.09,0.48 and 0.50,respectively(n=6).The overall clinical effective rate for white lesion of vulva was 100%. Conclusion: The placenta polypeptide injection is simple in preparation technique and feasible in quality control.No ad-verse drug reactions were found and the clinical effect is satisfactory.
Objective: To prepare the placenta polypeptide injection and establish the standard of quality control and to evaluate the therapeutic effect on white lesion of vulva. Methods: The placenta polypeptide injection was made from healthy human placenta by the method of thaw and ultrafiltration.The content of polypeptide was determined by Lowry-method. Results: The linear relationship of placenta polypeptide was found from 20μg/mL to 100μg/mL.The average recovery of polypeptide was 100.16%,99.25% and 98.59%,respectively.RSD was 1.09,0.48 and 0.50,respectively(n=6).The overall clinical effective rate for white lesion of vulva was 100%. Conclusion: The placenta polypeptide injection is simple in preparation technique and feasible in quality control.No ad-verse drug reactions were found and the clinical effect is satisfactory.
2007, (2): 94-97.
Abstract:
Objective: To optimize the formulation of 5-ISMN orally disintegrating tablets,and inspect quality of prepared tablets. Methods: The orthogonal design was used and HPLC was used to determine the concentration. Results: Besides 5-ISMN,the tablets were composed of croscarmellose sodium 3%,mannite 15%,lactose 31%,MCC/L-HPC ratio was 8:2(32%,8%).The prepared tablets disintegrated completely in 20s,dissolved more than 80% in 2min and tasty fine. Conclusion: Choose properly excipients,we can produce orally rapidly-disintegrating tablets of rapidly disintegrating,tasty well and rapid absorption.
Objective: To optimize the formulation of 5-ISMN orally disintegrating tablets,and inspect quality of prepared tablets. Methods: The orthogonal design was used and HPLC was used to determine the concentration. Results: Besides 5-ISMN,the tablets were composed of croscarmellose sodium 3%,mannite 15%,lactose 31%,MCC/L-HPC ratio was 8:2(32%,8%).The prepared tablets disintegrated completely in 20s,dissolved more than 80% in 2min and tasty fine. Conclusion: Choose properly excipients,we can produce orally rapidly-disintegrating tablets of rapidly disintegrating,tasty well and rapid absorption.
2007, (2): 98-99.
Abstract:
Objective: To find a ideal and unified mobile phase both of dissolution test and content determination of terfenadine tablets. Methods: HPLC was used. Results: The mobile phaseⅢ[a mobile phase composed of acetonitrile-phosphate buffer(50:50)] was applied,t_R is shorter,the peak shape is better and the methods are specific and sensitive. Conclusion: The mobile phaseⅢis recommended as a ideal and unified mobile phase of dissolution and determination for terfenadine tablets.
Objective: To find a ideal and unified mobile phase both of dissolution test and content determination of terfenadine tablets. Methods: HPLC was used. Results: The mobile phaseⅢ[a mobile phase composed of acetonitrile-phosphate buffer(50:50)] was applied,t_R is shorter,the peak shape is better and the methods are specific and sensitive. Conclusion: The mobile phaseⅢis recommended as a ideal and unified mobile phase of dissolution and determination for terfenadine tablets.
2007, (2): 100-101.
Abstract:
Objective: To study the influence factores of chloramphenicol release with sodium hyaluronate as vehicle in eye drops. Methods: The penetration rates of chloramphenicol were determined with modified Franz diffusion cell in solutions with different influ-ence factores. Results: The increase of solution viscosity could decrease the release rate of chloramphenicol.The release rates of chlor-amphenicol decreased with the concentrations of sodium hyaluronate increased and increased with the concentrations of chloramphenicol increased. Conclusion: The release rate of chloramphenicol in eye drops is concerned with viscosity of solution and drug concentration, but there is a limite to the drug sustained release by increasing viscosity of solution.
Objective: To study the influence factores of chloramphenicol release with sodium hyaluronate as vehicle in eye drops. Methods: The penetration rates of chloramphenicol were determined with modified Franz diffusion cell in solutions with different influ-ence factores. Results: The increase of solution viscosity could decrease the release rate of chloramphenicol.The release rates of chlor-amphenicol decreased with the concentrations of sodium hyaluronate increased and increased with the concentrations of chloramphenicol increased. Conclusion: The release rate of chloramphenicol in eye drops is concerned with viscosity of solution and drug concentration, but there is a limite to the drug sustained release by increasing viscosity of solution.
2007, (2): 102-103.
Abstract:
Objective: To optimize the synthesis of econazole nitrate,a useful antifungal agent. Methods: Orthogonal experimen-tal design is used and the influence of temperature,catalyst,reaction time and solvent on the yield is investigated. Results: Solvent is more important than reaction time and catalyst. Conclusion: The new method has several advantages such as cheap reactants,facile reaction condition,convenient operation and high yield.
Objective: To optimize the synthesis of econazole nitrate,a useful antifungal agent. Methods: Orthogonal experimen-tal design is used and the influence of temperature,catalyst,reaction time and solvent on the yield is investigated. Results: Solvent is more important than reaction time and catalyst. Conclusion: The new method has several advantages such as cheap reactants,facile reaction condition,convenient operation and high yield.
2007, (2): 117-120.
Abstract:
Objective: To explore the cost-effectiveness of different chemothrapeutic schemes in the treatment of advanced gastric cancer. Methods: 96 cases of gastric cancer were divided into three groups receiving different medication.A group(32 cases)with Do-cetaxel+Fluorouracil(5-FU)+Calcium folinate(CF)+Cisplatin(DDP);B group(30 cases)with Epirubicin+DDP+5-FU+CF; C group(34 cases)with Oxaliplatin+5-FU+CF.Date was evaluated using clinic economics cost-effectiveness analysis. Results: A-mong three groups,the effective rate of A group was 56.25% and expenditure of one therapeutic course was 9979 yuans,1% increase of effective rate 177.40 yuans.The effective rate of A group was 40.00% and expenditure of one therapeutic course was 4158 yuans, increase of 1% effective rate was costed 103.95yuans.The effective rate of C group was 52.94% and expenditure of one therapeutic course was 4498 yuans,1% increase of effective rate costed 84.96 yuans. Conclusion: C schemes is the most rational one among three chemotherapeutic programs for advanced gastric cancer.
Objective: To explore the cost-effectiveness of different chemothrapeutic schemes in the treatment of advanced gastric cancer. Methods: 96 cases of gastric cancer were divided into three groups receiving different medication.A group(32 cases)with Do-cetaxel+Fluorouracil(5-FU)+Calcium folinate(CF)+Cisplatin(DDP);B group(30 cases)with Epirubicin+DDP+5-FU+CF; C group(34 cases)with Oxaliplatin+5-FU+CF.Date was evaluated using clinic economics cost-effectiveness analysis. Results: A-mong three groups,the effective rate of A group was 56.25% and expenditure of one therapeutic course was 9979 yuans,1% increase of effective rate 177.40 yuans.The effective rate of A group was 40.00% and expenditure of one therapeutic course was 4158 yuans, increase of 1% effective rate was costed 103.95yuans.The effective rate of C group was 52.94% and expenditure of one therapeutic course was 4498 yuans,1% increase of effective rate costed 84.96 yuans. Conclusion: C schemes is the most rational one among three chemotherapeutic programs for advanced gastric cancer.
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