2006 Vol. 24, No. 2
Display Method:
2006, (2): 81-83.
Abstract:
Objective : To study the effects of Qingzhiyuan soft capsule(QZY)on blood lipid and antioxidant activity in hyperlipi-demia rats. Methods : Fifty Wister rats were randomly divided into five groups according to body weight and serum cholesterol levels.They were fed one of five diets, a reference diet, a high fat supplemented diet and a high fat supplemented with 20mg/kg, 5mg/kg QZY, a positive diets.After three weeks, blood lipid and antioxidant activity were determined respectively. Results : Compared with model, QZY could reduced the serum TC, TG, LDL-C concentration, increased SOD and GSH-Px activities, decreased MDA level significantly(P<0.05). Conclusion : QZY might play an important role in preventing hyperlipidemia through its antioxidative effect.
Objective : To study the effects of Qingzhiyuan soft capsule(QZY)on blood lipid and antioxidant activity in hyperlipi-demia rats. Methods : Fifty Wister rats were randomly divided into five groups according to body weight and serum cholesterol levels.They were fed one of five diets, a reference diet, a high fat supplemented diet and a high fat supplemented with 20mg/kg, 5mg/kg QZY, a positive diets.After three weeks, blood lipid and antioxidant activity were determined respectively. Results : Compared with model, QZY could reduced the serum TC, TG, LDL-C concentration, increased SOD and GSH-Px activities, decreased MDA level significantly(P<0.05). Conclusion : QZY might play an important role in preventing hyperlipidemia through its antioxidative effect.
2006, (2): 83-86.
Abstract:
Objective : To study the effects of six flavonoids (fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone)on collagen synthesis of immortallized rat hepatic stellate cell line HSC-T6 cells. Methods : Collagen synthesis was determined by 3H-proline incorporation. Results :Fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone (12.5-50μmol/L)concentration-dependently diminished collagen synthesis stimulated by serum, macrophage conditioned medium (MCM)and transforming growth factorβ1(TGFβ1). Conclusion :The six flavonoids inhibited the collagen synthesis of hepatic stellate cells, which may have potential therapeutic effects against liver fibrosis.
Objective : To study the effects of six flavonoids (fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone)on collagen synthesis of immortallized rat hepatic stellate cell line HSC-T6 cells. Methods : Collagen synthesis was determined by 3H-proline incorporation. Results :Fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone (12.5-50μmol/L)concentration-dependently diminished collagen synthesis stimulated by serum, macrophage conditioned medium (MCM)and transforming growth factorβ1(TGFβ1). Conclusion :The six flavonoids inhibited the collagen synthesis of hepatic stellate cells, which may have potential therapeutic effects against liver fibrosis.
2006, (2): 86-89.
Abstract:
Objective : To investigate the compatible stability of ampicoxacillin sodium for injection in five infusions in different time and different temperature conditions. Methods : Ampicloxacillin sodium was dissolved in five infusions.Ampicillin and cloxacillin in ampicloxacillin sodium for injection were determined by HPLC,and the color changes of all infusions were observed. Results : The ampicillin and eloxacillin contents in ampicloxacillin sodium for injection declined with time and temperature increased.The most distinct were 5% glucose injection. Concision : Ampicloxacillin sodium for injection wasn't stable in 5% glucose, gluscose and sodium chloride injection.
Objective : To investigate the compatible stability of ampicoxacillin sodium for injection in five infusions in different time and different temperature conditions. Methods : Ampicloxacillin sodium was dissolved in five infusions.Ampicillin and cloxacillin in ampicloxacillin sodium for injection were determined by HPLC,and the color changes of all infusions were observed. Results : The ampicillin and eloxacillin contents in ampicloxacillin sodium for injection declined with time and temperature increased.The most distinct were 5% glucose injection. Concision : Ampicloxacillin sodium for injection wasn't stable in 5% glucose, gluscose and sodium chloride injection.
2006, (2): 89-92.
Abstract:
Objective :To evaluate the quality of three different products of water-soluable vitamin for injection(prouducted by AV, BV and CV respectively)and to make a reference for clinical application. Methods : several indicators were compared, such as the physical and chemical properties of the products, the pH, the solubility, the difference at the load capacity, the insoluble particles, the transparency clarity , the content and the toxin produced by certain bacteria according to the quality standards of the same kind prouducts at home and abroad Results :The color of sample varies from light yellow to brown yellow,even the color is diffent at spot.The pH values were between 5.6 -6.1.The powder and injection preparation dissolved in five minutes.The results of the tests of the transparency clarity, the difference at the load capacity and the toxin produced were complied with the Chinese Pharmacopoeia about the request of the injection.The amount of sub-visible particles whose size was larger than 10 or 25μm were accordence with the Chinese Pharmacopoeia.But The amount of sub-visible particles were different among products made in different manufacturers.For the content of vitamin or preservative,just three batches which made in AV were accordence with the standard of MOH among batches .Individual batch numbers that prouducted by the others could not meet the standard requests of the Ministry of Heal. Conclusion : On the whole,the quality is not too bad,but the quality of product made by different manufacturers has some difference.
Objective :To evaluate the quality of three different products of water-soluable vitamin for injection(prouducted by AV, BV and CV respectively)and to make a reference for clinical application. Methods : several indicators were compared, such as the physical and chemical properties of the products, the pH, the solubility, the difference at the load capacity, the insoluble particles, the transparency clarity , the content and the toxin produced by certain bacteria according to the quality standards of the same kind prouducts at home and abroad Results :The color of sample varies from light yellow to brown yellow,even the color is diffent at spot.The pH values were between 5.6 -6.1.The powder and injection preparation dissolved in five minutes.The results of the tests of the transparency clarity, the difference at the load capacity and the toxin produced were complied with the Chinese Pharmacopoeia about the request of the injection.The amount of sub-visible particles whose size was larger than 10 or 25μm were accordence with the Chinese Pharmacopoeia.But The amount of sub-visible particles were different among products made in different manufacturers.For the content of vitamin or preservative,just three batches which made in AV were accordence with the standard of MOH among batches .Individual batch numbers that prouducted by the others could not meet the standard requests of the Ministry of Heal. Conclusion : On the whole,the quality is not too bad,but the quality of product made by different manufacturers has some difference.
2006, (2): 93-95.
Abstract:
Objective :To study the influence of compound sepia capsules on the function of anti-aging. Methods : Fruit flies survival test was explored.The malondialdehyde(MAD),SOD and glutathione peroxidase (GSH-PX)in the rats blood and tissue were determined . Results : The compound sepia capsules prolonged survival time of the fruit flies, decreased the MAD in the serum, liver and kidney of the rats and improved the activeness of the SOD in the serum and tissue.The test indicated that the compound sepia capsules had the function of anti-aging significantly. Conclusion : The compound sepia capsules can prolong life.
Objective :To study the influence of compound sepia capsules on the function of anti-aging. Methods : Fruit flies survival test was explored.The malondialdehyde(MAD),SOD and glutathione peroxidase (GSH-PX)in the rats blood and tissue were determined . Results : The compound sepia capsules prolonged survival time of the fruit flies, decreased the MAD in the serum, liver and kidney of the rats and improved the activeness of the SOD in the serum and tissue.The test indicated that the compound sepia capsules had the function of anti-aging significantly. Conclusion : The compound sepia capsules can prolong life.
2006, (2): 99-100.
Abstract:
Objections : To establish the quality standards of the tannin in tannin-cod liver oil ointment. Methods :The content of the tannin was determined by compleximetry. Results : The equal content of the tannin in ointment was 4.77% ,RSD was 2.41% . Conclusion :These methods are specific and accurate.They can be used as the quality control method for the tannin in tannin-cod liver oil ointment.
Objections : To establish the quality standards of the tannin in tannin-cod liver oil ointment. Methods :The content of the tannin was determined by compleximetry. Results : The equal content of the tannin in ointment was 4.77% ,RSD was 2.41% . Conclusion :These methods are specific and accurate.They can be used as the quality control method for the tannin in tannin-cod liver oil ointment.
2006, (2): 101-103.
Abstract:
Objective : To establish a method for determination of contents in Xieliting tablets. Methods : The computer-aided con-juction curve method had been applied to determine sulfamethoxazol and trimethoprim. Results : The corresponding average recovery and the relative standard deviation of sulfamethoxazol and trimethoprim were 99.85% ,0.53% , 102.01% ,3.14% ,the linear range of sultamethoxazol and trimethoprim were 0-20μg/mL,0-12μg/mL. Conclusions : The method was satisfactory, simple and convenient and had a good accuracy.
Objective : To establish a method for determination of contents in Xieliting tablets. Methods : The computer-aided con-juction curve method had been applied to determine sulfamethoxazol and trimethoprim. Results : The corresponding average recovery and the relative standard deviation of sulfamethoxazol and trimethoprim were 99.85% ,0.53% , 102.01% ,3.14% ,the linear range of sultamethoxazol and trimethoprim were 0-20μg/mL,0-12μg/mL. Conclusions : The method was satisfactory, simple and convenient and had a good accuracy.
2006, (2): 107-108.
Abstract:
Objective : To evaluate cost-effectiveness of irbesartan and benazepril in the treatment of primary hypertension. Methods : According to literatures and method of cost-effectiveness analysis, two drugs with the treatment of primary hypertension were eco-nomicaly evaluated. Results and Conclusion : There were no obvious difference between these two projects in treating primary hypertension.The cost of treatment of two drugs were 998.68 and 923.08 yuan.The cost-effectiveness ratio of benazepril is superior to that of irbesartan.
Objective : To evaluate cost-effectiveness of irbesartan and benazepril in the treatment of primary hypertension. Methods : According to literatures and method of cost-effectiveness analysis, two drugs with the treatment of primary hypertension were eco-nomicaly evaluated. Results and Conclusion : There were no obvious difference between these two projects in treating primary hypertension.The cost of treatment of two drugs were 998.68 and 923.08 yuan.The cost-effectiveness ratio of benazepril is superior to that of irbesartan.
2006, (2): 109-112.
Abstract:
Objective : To study on the utilization of hypoglycemic agents in a hospital from 2001 to 2005. Methods : Making a statistic analysis of transaction data on sum of consume and money and concluding the trends of drug utilization. Results : Both the sum of drug consume and money were increasing.The utility of some drugs with more adverse reactions were decreasing.However, the utility of other new safer drugs were rising. Conclusion : Both doctors and patients thought more of the diagnosis and therapy of diabetes, but the knowledges about the usage and choice of hypoglycemic agents should be improved.
Objective : To study on the utilization of hypoglycemic agents in a hospital from 2001 to 2005. Methods : Making a statistic analysis of transaction data on sum of consume and money and concluding the trends of drug utilization. Results : Both the sum of drug consume and money were increasing.The utility of some drugs with more adverse reactions were decreasing.However, the utility of other new safer drugs were rising. Conclusion : Both doctors and patients thought more of the diagnosis and therapy of diabetes, but the knowledges about the usage and choice of hypoglycemic agents should be improved.
2006, (2): 112-116.
Abstract:
Objective :To analyze the situation the utility of antibacterials in order to promote the rational drug use. Methods :The data of the antibacterial use during 2002-2004 were study by the methods of DDD analysis and ranking of amount of money. Results : Cephalosporins, Fcuoquinolones and Penicillins are the most frequent among used antibacterials.In terms of the ranking of amount of money, most of the drugs ranking in the first 30 places were expensive or in large use. Conclusion : Some problems for application of antibacterials should not be ignored in our hospital.
Objective :To analyze the situation the utility of antibacterials in order to promote the rational drug use. Methods :The data of the antibacterial use during 2002-2004 were study by the methods of DDD analysis and ranking of amount of money. Results : Cephalosporins, Fcuoquinolones and Penicillins are the most frequent among used antibacterials.In terms of the ranking of amount of money, most of the drugs ranking in the first 30 places were expensive or in large use. Conclusion : Some problems for application of antibacterials should not be ignored in our hospital.
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