2004 Vol. 22, No. 5
Display Method:
2004, (5): 257-259.
Abstract:
Objective To evaluate the methods and conclusions of lidocaine's effects on electricity-kindling models. Methods The recent papers touching upon lidocaine's effects on electricity-kindling models were analyzed and compared. Results Different investigator had different or even converse conclusions. Conclusion The investigation should have unitary criteria and the conclusions should not be reached readily.
Objective To evaluate the methods and conclusions of lidocaine's effects on electricity-kindling models. Methods The recent papers touching upon lidocaine's effects on electricity-kindling models were analyzed and compared. Results Different investigator had different or even converse conclusions. Conclusion The investigation should have unitary criteria and the conclusions should not be reached readily.
2004, (5): 264-267.
Abstract:
Objective To introduce the development on the constituents and pharmacology of traditional Chinese medicine Zan-thoxylum nitidum. Methods The correlated literature at home and abroad was reviewed. Result and Conclusion Various types of alkaloids have been isolatecd from Zanthoxylum nitidum and they are all of high content. The effective constitutes of antitumor and analgesia have been convinced. Due to the antitumor activity of the alkaloids and relaxation pain of cancer of crystal-8, Zanthoxylum nitidum has high value in the research of cancer therapy.
Objective To introduce the development on the constituents and pharmacology of traditional Chinese medicine Zan-thoxylum nitidum. Methods The correlated literature at home and abroad was reviewed. Result and Conclusion Various types of alkaloids have been isolatecd from Zanthoxylum nitidum and they are all of high content. The effective constitutes of antitumor and analgesia have been convinced. Due to the antitumor activity of the alkaloids and relaxation pain of cancer of crystal-8, Zanthoxylum nitidum has high value in the research of cancer therapy.
2004, (5): 268-270.
Abstract:
Objective To explore the effect of Astragalus membranaceus injection on congestive heart failure and immune regulation. Methods The serum levers of IgA IgG IgM C3 IL-Ⅱ E-RFC T-LTT and antibody of cardiac muscle were measured in normal control group and CHF group. Then the CHF patients were divided randomly into two groups. Treatment group was infused intravenously daily with Astragalus membranaceus injection added into 5% glucose 250mL for two weeks, which was based on conventional therapy such as digitalis, diuretics and vasodilators. Conventional therapy group was only treated with conventional thearpy. Previous measurements were done again after two weeks. Comparative analysis was made between normal control group and CHF group, and also was made between conventional therapy group and treatment group. Results The level of IL-Ⅱ E-RFC T-LTT antibody of cardiac muscle in the CHF paients were significantly higher then that of normal control group (P<0.01). After two weeks, there was no significant difference in the total effective rate of CHF between two groups (P>0.05), but the obvious effective rate of treatment group was markedly higher than that of conventional therapy group(P >0.05). The decrease of IL-Ⅱ E-RFC T-LTT C3 and antibody of cardiac muscle in treatment group is more obvious than that in conventional therapy group (P<0.01). Conclusion The effect of Astragalus membranaceus injection on cogestive heart failure involves mainly the cell immune and Astragalus membranaceus may have a satisfied cure effect on it.
Objective To explore the effect of Astragalus membranaceus injection on congestive heart failure and immune regulation. Methods The serum levers of IgA IgG IgM C3 IL-Ⅱ E-RFC T-LTT and antibody of cardiac muscle were measured in normal control group and CHF group. Then the CHF patients were divided randomly into two groups. Treatment group was infused intravenously daily with Astragalus membranaceus injection added into 5% glucose 250mL for two weeks, which was based on conventional therapy such as digitalis, diuretics and vasodilators. Conventional therapy group was only treated with conventional thearpy. Previous measurements were done again after two weeks. Comparative analysis was made between normal control group and CHF group, and also was made between conventional therapy group and treatment group. Results The level of IL-Ⅱ E-RFC T-LTT antibody of cardiac muscle in the CHF paients were significantly higher then that of normal control group (P<0.01). After two weeks, there was no significant difference in the total effective rate of CHF between two groups (P>0.05), but the obvious effective rate of treatment group was markedly higher than that of conventional therapy group(P >0.05). The decrease of IL-Ⅱ E-RFC T-LTT C3 and antibody of cardiac muscle in treatment group is more obvious than that in conventional therapy group (P<0.01). Conclusion The effect of Astragalus membranaceus injection on cogestive heart failure involves mainly the cell immune and Astragalus membranaceus may have a satisfied cure effect on it.
2004, (5): 271-273.
Abstract:
Objective To analyse the drug resistance of the stenotrophomonas maltophilia in order to guide rational drug using in clinical. Methods The automatic drug sensitive test and method that the paper spreads medicine sensitive test were carried on to 101 stems of the stenotrophomonas maltophilia with the index of the VITEK system, and drug sensitive test with long-term difficult to treat nature's stenotrophomonas maltophilia infection patient was carried once a week. Results In all clinical samples,stenotrophomonas maltophilia separated from phlegm liquid is the most (75%), then is the clear urine(10%),this fungus is nature resistance to the action of the iminepinan. The drug resistance of ampicillin,amoxicillin/clavulanic acid,cefazolin,furantoin,cefuroxime are 100%. Amika-cin, aztreonam, cefmetazole, ceftriaxone, cefotaxime, gentamicin's sensitive rate are under 20%, for levofloxacin, Compound sinomin, ceftazidime,cefoperazone/sulbactam,the drug resistance is 18.92%,22.86%,13.95%,2.50% respectively. Conclusion Stenotrophomonas maltophilia is the important pathogen fungus that infects in hospital, and resistance to most of the antibiotics, Cefoperazone/sul-bactam is the first-selected medicine for it; Stenotrophomonas maltophilia is easy to produce medicament inductivity resistance to a few sensitive drugs.
Objective To analyse the drug resistance of the stenotrophomonas maltophilia in order to guide rational drug using in clinical. Methods The automatic drug sensitive test and method that the paper spreads medicine sensitive test were carried on to 101 stems of the stenotrophomonas maltophilia with the index of the VITEK system, and drug sensitive test with long-term difficult to treat nature's stenotrophomonas maltophilia infection patient was carried once a week. Results In all clinical samples,stenotrophomonas maltophilia separated from phlegm liquid is the most (75%), then is the clear urine(10%),this fungus is nature resistance to the action of the iminepinan. The drug resistance of ampicillin,amoxicillin/clavulanic acid,cefazolin,furantoin,cefuroxime are 100%. Amika-cin, aztreonam, cefmetazole, ceftriaxone, cefotaxime, gentamicin's sensitive rate are under 20%, for levofloxacin, Compound sinomin, ceftazidime,cefoperazone/sulbactam,the drug resistance is 18.92%,22.86%,13.95%,2.50% respectively. Conclusion Stenotrophomonas maltophilia is the important pathogen fungus that infects in hospital, and resistance to most of the antibiotics, Cefoperazone/sul-bactam is the first-selected medicine for it; Stenotrophomonas maltophilia is easy to produce medicament inductivity resistance to a few sensitive drugs.
2004, (5): 274-275.
Abstract:
Objective To investigate if sodium polyacrylate, a kind of superabsorbent polymer widely used in infant diaper and feminine napkin, has laxative effect. Methods Mice bowel motion test and keeping water test were carried out and mice constipation models were treated. Results It was found that sodium polyacrylate could increase intestine motion significantly and make intestine keeping more water than placebo,and treat constipation effectively. Conclusion Sodium polyacrylate has laxative effect.
Objective To investigate if sodium polyacrylate, a kind of superabsorbent polymer widely used in infant diaper and feminine napkin, has laxative effect. Methods Mice bowel motion test and keeping water test were carried out and mice constipation models were treated. Results It was found that sodium polyacrylate could increase intestine motion significantly and make intestine keeping more water than placebo,and treat constipation effectively. Conclusion Sodium polyacrylate has laxative effect.
2004, (5): 276-277.
Abstract:
Objective To establish a quantitative analysis method for benzoic acid and salicylic acid in compound benzoic acid tincture. Methods The benzoic acid was determined directly at 272 and 301 nm by dual-wavelength ratio coefficient spectrometry. The salicylic acid was determined directly at 318nm by first derivative spectrometry. Results The calibration curve of benzoic acid was linear in the range from 19.34 to 27.08μg/mL with r =0.9999,the average recovery and relative standard deviation were 99.4% and 0.80% respectively. The calibration curve of salicylic acid was linear in the range from 24.48 to 34.27μg/mL with r =0.9999, the average recovery and RSD were 99.6% and 0.49% respectively. Conclusion The method is simple,rapid and accurate.
Objective To establish a quantitative analysis method for benzoic acid and salicylic acid in compound benzoic acid tincture. Methods The benzoic acid was determined directly at 272 and 301 nm by dual-wavelength ratio coefficient spectrometry. The salicylic acid was determined directly at 318nm by first derivative spectrometry. Results The calibration curve of benzoic acid was linear in the range from 19.34 to 27.08μg/mL with r =0.9999,the average recovery and relative standard deviation were 99.4% and 0.80% respectively. The calibration curve of salicylic acid was linear in the range from 24.48 to 34.27μg/mL with r =0.9999, the average recovery and RSD were 99.6% and 0.49% respectively. Conclusion The method is simple,rapid and accurate.
2004, (5): 278-280.
Abstract:
Objective To study antitussive, expectorant and antiasthmatic actions of Qiguanye pill. Methods Histamine was used to induce tracheaspasm in whole body and Guinea pig's isolated trachea test was used to observe the antiasthmatic action Of Qiguanye pill. Phenol red test was used to observe its expectorant action in mice. The cough of animal was induced by ammonia water to trachea tract. Results Qiguanye pill could obviously prolong the incubation period of asthma produced by histamine and also could markedly reduce the contraction amplitude, induced by histamine and acetylcholine of isolated trachea of Guinea pig. The contraction amplitudes were reduced. It could markedly increase excretion of phenol red in the trachial cavity of mice and could obviously reduce cough times of felines and mice. Conclusion Qiguanye pill has good antitussive,expectorant and antiasthmatic actions.
Objective To study antitussive, expectorant and antiasthmatic actions of Qiguanye pill. Methods Histamine was used to induce tracheaspasm in whole body and Guinea pig's isolated trachea test was used to observe the antiasthmatic action Of Qiguanye pill. Phenol red test was used to observe its expectorant action in mice. The cough of animal was induced by ammonia water to trachea tract. Results Qiguanye pill could obviously prolong the incubation period of asthma produced by histamine and also could markedly reduce the contraction amplitude, induced by histamine and acetylcholine of isolated trachea of Guinea pig. The contraction amplitudes were reduced. It could markedly increase excretion of phenol red in the trachial cavity of mice and could obviously reduce cough times of felines and mice. Conclusion Qiguanye pill has good antitussive,expectorant and antiasthmatic actions.
2004, (5): 281-282.
Abstract:
Objective To observe the clinical effectiveness for two program in women with NGU. Methods 90 patients were divided into treatment group and control group randomly. The treatment group was treated orally in combination with azithromycin, ofloxacin and doxycycline. The control group was treated orally with azithromycin only. The course of both groups was 14 days. Results The total effective rate of treatment group was 100% and the recurrence rate was 0%, while the total effective rate of control group was 85% and the recurrence rate was 30%. Conclusion The combined treatment achieves the better curative effect than the control group in treating NGU.
Objective To observe the clinical effectiveness for two program in women with NGU. Methods 90 patients were divided into treatment group and control group randomly. The treatment group was treated orally in combination with azithromycin, ofloxacin and doxycycline. The control group was treated orally with azithromycin only. The course of both groups was 14 days. Results The total effective rate of treatment group was 100% and the recurrence rate was 0%, while the total effective rate of control group was 85% and the recurrence rate was 30%. Conclusion The combined treatment achieves the better curative effect than the control group in treating NGU.
2004, (5): 284-287.
Abstract:
Objective To compare the bioavailability of cefixime tablets and capsules with Cefspan's (marketed cefixime capsules) in human subjects. Methods A reversed-phase high performance liquid chromatography was used for the determination of cefixime in plasma after a single oral dose of 400mg cefixime tablets,capsules and cefspan in a crossover design. Results The pharmaco-kinetic parameters of cefixime tablets, capsules and cefspan are as follows: AUC0→1(27.29±8.76)μg/mL·h,(28.12±8.91)μg/mL·h and(27.76±8.25)μg/mL·h,AUC0→∞(28.12±9.11)μg/mL·h,(28.98 ±9.33)μg/mL·h and(28.72±8.78)μg/mL·h,tmax(4.00±0.36)h,(4.00±0.35)h and (4.00±0.37)h.Cmax(4.75±1.21)μg/mL,(4.76±1.05)μg/mL and(4.75 ±1.10)μg/mL,t1/2(2.70±0.38)h, (2.65±0.57)h and (2.78±0.61)h, MRT0-T(5.52±0.60)h, (5.57±0.59)h and (5.54±0.57)h. Conclusion The cefixime capsules and tablets are bioequivalent with Cefspan.
Objective To compare the bioavailability of cefixime tablets and capsules with Cefspan's (marketed cefixime capsules) in human subjects. Methods A reversed-phase high performance liquid chromatography was used for the determination of cefixime in plasma after a single oral dose of 400mg cefixime tablets,capsules and cefspan in a crossover design. Results The pharmaco-kinetic parameters of cefixime tablets, capsules and cefspan are as follows: AUC0→1(27.29±8.76)μg/mL·h,(28.12±8.91)μg/mL·h and(27.76±8.25)μg/mL·h,AUC0→∞(28.12±9.11)μg/mL·h,(28.98 ±9.33)μg/mL·h and(28.72±8.78)μg/mL·h,tmax(4.00±0.36)h,(4.00±0.35)h and (4.00±0.37)h.Cmax(4.75±1.21)μg/mL,(4.76±1.05)μg/mL and(4.75 ±1.10)μg/mL,t1/2(2.70±0.38)h, (2.65±0.57)h and (2.78±0.61)h, MRT0-T(5.52±0.60)h, (5.57±0.59)h and (5.54±0.57)h. Conclusion The cefixime capsules and tablets are bioequivalent with Cefspan.
2004, (5): 287-289.
Abstract:
Objective To study the preparation of resident compound ofloxacin eye drops and its quality control. Methods Ofloxacin was used as main drug mixed with dexamethasone sodium phosphate and phosphate was adopted as buffer, while carbomer 940 as residence. The content of ofloxacin was determined by HPLC method. Results The preparations was stable, the average recovery rate of ofloxacin was (99.8±0.5)% (n=5) and that of dexamethasone sodium phosphate was (100.6±0.8)%(n=5). Conclusion; The preparing technique is simple and the quality control is reliable.
Objective To study the preparation of resident compound ofloxacin eye drops and its quality control. Methods Ofloxacin was used as main drug mixed with dexamethasone sodium phosphate and phosphate was adopted as buffer, while carbomer 940 as residence. The content of ofloxacin was determined by HPLC method. Results The preparations was stable, the average recovery rate of ofloxacin was (99.8±0.5)% (n=5) and that of dexamethasone sodium phosphate was (100.6±0.8)%(n=5). Conclusion; The preparing technique is simple and the quality control is reliable.
2004, (5): 289-290.
Abstract:
Objective To prepare metronidazole cream and establish quality control standard. Methods The cream was prepared by taking metronidazole as main components. The contents of metronidazole was determined by UV spectrometry. Results The average recovery of metronidazole was 100.2%, RSD was 1.7%. Conclusion The cream can be prepare feasibly. The method of quality control is simple,rapid and accurate.
Objective To prepare metronidazole cream and establish quality control standard. Methods The cream was prepared by taking metronidazole as main components. The contents of metronidazole was determined by UV spectrometry. Results The average recovery of metronidazole was 100.2%, RSD was 1.7%. Conclusion The cream can be prepare feasibly. The method of quality control is simple,rapid and accurate.
2004, (5): 291-293.
Abstract:
Objective To establish nonaqueous acicle-base electrolytic titrations method for the determination of adefovir dipivoxil raw material, and investigate the infulents of the proportion of acetic anhydride in the acetric anhydride and anhydro-glacial acetic acid mixed solution. Methods 75% acetric anhydride was selected as the solvent, and 0.1 mol/L perchloric was selected as the standard solution to determine the content of adefovir dipivoxil in raw material. Results It was found that the end point was changed more acuate with the increasing of acetric anhydride proportion in solvent. The average recovery of adefovir dipivoxil raw material was 99.7% and RSD was 0.2%. Conclusion The method was simple, accurate, and is suitable for the quality control of adefovir dipivoxil raw material.
Objective To establish nonaqueous acicle-base electrolytic titrations method for the determination of adefovir dipivoxil raw material, and investigate the infulents of the proportion of acetic anhydride in the acetric anhydride and anhydro-glacial acetic acid mixed solution. Methods 75% acetric anhydride was selected as the solvent, and 0.1 mol/L perchloric was selected as the standard solution to determine the content of adefovir dipivoxil in raw material. Results It was found that the end point was changed more acuate with the increasing of acetric anhydride proportion in solvent. The average recovery of adefovir dipivoxil raw material was 99.7% and RSD was 0.2%. Conclusion The method was simple, accurate, and is suitable for the quality control of adefovir dipivoxil raw material.
2004, (5): 293-294.
Abstract:
Objective To establish a HPLC-ECD method for determination of nitrite remaining in gliclazide. Methods A colum of Hypersil-SAX was used. The mobile phase was 13.61g of sodium acetate dissolved in water(pH4.3) with phosphoric acid and diluted to 1000mL. Results The linear range was 0.04～0.80μg(r= 0.9995). The average recovery was 99.2% RSD = 1.7% (n = 9). Conclusion The method was simple and accurate.
Objective To establish a HPLC-ECD method for determination of nitrite remaining in gliclazide. Methods A colum of Hypersil-SAX was used. The mobile phase was 13.61g of sodium acetate dissolved in water(pH4.3) with phosphoric acid and diluted to 1000mL. Results The linear range was 0.04～0.80μg(r= 0.9995). The average recovery was 99.2% RSD = 1.7% (n = 9). Conclusion The method was simple and accurate.
2004, (5): 294-296.
Abstract:
Objective To establish three variables complex chromometry for the determination of berberine in compound Sophora flavescens lotions. Methods The berberine formed three variables complex with bromophenol blue and quinine in pH6.7,then it was withdrawn with chloroform. The detection wavelength was 610nm. Results The linear range of berberine was the 0.8～4mg/L(r = 0.9999),the average recovery was 98.65%,RSD was 1.12%. Conclusion The method had a good sensitive, and reproducibility. It can be used for determination of berberine in compound sophora flavescens lotions.
Objective To establish three variables complex chromometry for the determination of berberine in compound Sophora flavescens lotions. Methods The berberine formed three variables complex with bromophenol blue and quinine in pH6.7,then it was withdrawn with chloroform. The detection wavelength was 610nm. Results The linear range of berberine was the 0.8～4mg/L(r = 0.9999),the average recovery was 98.65%,RSD was 1.12%. Conclusion The method had a good sensitive, and reproducibility. It can be used for determination of berberine in compound sophora flavescens lotions.
2004, (5): 296-297.
Abstract:
Objective To develop a method for determination of content of camphor in camphor cream. Methods The content of camphor in camphor cream was determined by UV spectrophotometry.The detection wavelength was (289 ±1) nm. Results There was a good linear relation between camphor content and Abs in the range of 1.28～3.84mg/mL. The average recovery was 101.7% with RSD of 0.4%. Conclusion The method is simple and accurate.
Objective To develop a method for determination of content of camphor in camphor cream. Methods The content of camphor in camphor cream was determined by UV spectrophotometry.The detection wavelength was (289 ±1) nm. Results There was a good linear relation between camphor content and Abs in the range of 1.28～3.84mg/mL. The average recovery was 101.7% with RSD of 0.4%. Conclusion The method is simple and accurate.
2004, (5): 298-298,312.
Abstract:
Objective To establish an accurate method for determination of the content of oxacillin sodium for injection. Methods Oxacillin sodium for injection was determinted with as water by polarimetry. Results The standard curve was linear in the range of 1～10 mg/mL. The regression equation was: C = 0.391 314 + 5.261 50a,r = 0.9997. The average recovery rate was 102.1%,RSD
Objective To establish an accurate method for determination of the content of oxacillin sodium for injection. Methods Oxacillin sodium for injection was determinted with as water by polarimetry. Results The standard curve was linear in the range of 1～10 mg/mL. The regression equation was: C = 0.391 314 + 5.261 50a,r = 0.9997. The average recovery rate was 102.1%,RSD
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