2002 Vol. 20, No. 3
Display Method:
2002, (3): 152-154.
Abstract:
OBJECTIVE To discuss the identification and specific characterization between the domestic urapidil and the imported ebrantil through the clinical efficacy research for the patients with hypertensio METHODS The doubleblind method was selected.RESULTS The better advances of SBP、SDP、HR were significant after given above mentioned drugs and always kept the lower level for 24 hours.The total efficacy of URA team and EBR team were 97.4%,95.2%,respect ively,which have no significant diference each other.CONCLUSION There pharmacological mechanism,efficacy,safety and quickly effect,moderate decrease of blood-pressure and little side adverse effect were no significant diferent.
OBJECTIVE To discuss the identification and specific characterization between the domestic urapidil and the imported ebrantil through the clinical efficacy research for the patients with hypertensio METHODS The doubleblind method was selected.RESULTS The better advances of SBP、SDP、HR were significant after given above mentioned drugs and always kept the lower level for 24 hours.The total efficacy of URA team and EBR team were 97.4%,95.2%,respect ively,which have no significant diference each other.CONCLUSION There pharmacological mechanism,efficacy,safety and quickly effect,moderate decrease of blood-pressure and little side adverse effect were no significant diferent.
2002, (3): 157-159.
Abstract:
OBJECTIVE To study the five stability of buflomedil hydrochloride in five injection solutions METHODS The content of buflomedil hydrochloride was determined by UV spectrophotometery The appearance Ph and change of buflomedil hydrochloride of UV spectrum in 9 hours RESULTS Buflomedil hydrochloride in five injection solution at 25℃、37℃ in 9 hours was stable The quantity of buflomedil hydrochloride was over 98.5%.CONCLUSION The solutions prepared were compatible and clinical applicable.
OBJECTIVE To study the five stability of buflomedil hydrochloride in five injection solutions METHODS The content of buflomedil hydrochloride was determined by UV spectrophotometery The appearance Ph and change of buflomedil hydrochloride of UV spectrum in 9 hours RESULTS Buflomedil hydrochloride in five injection solution at 25℃、37℃ in 9 hours was stable The quantity of buflomedil hydrochloride was over 98.5%.CONCLUSION The solutions prepared were compatible and clinical applicable.
2002, (3): 171-173.
Abstract:
OBJECTIVE To improve the method for determination compound fluocinonide ointment.METHODS A method of RP HPLC be used, plus the internal standard after extraction and filter.ODS column (250mm×4.6mm, 5μm) was selected and the mobile phase was consisted of methanol-water-ether(62:38:2,v/v/v) at flow rate of 1.0ml·min-1.The detection wavelength was 240nm.RESULTS The precision and the accuracy of improved method are good.CONCLUSION The problem of the old method was solved with this improved method and have a universal significance for the determination of ointment preparation.
OBJECTIVE To improve the method for determination compound fluocinonide ointment.METHODS A method of RP HPLC be used, plus the internal standard after extraction and filter.ODS column (250mm×4.6mm, 5μm) was selected and the mobile phase was consisted of methanol-water-ether(62:38:2,v/v/v) at flow rate of 1.0ml·min-1.The detection wavelength was 240nm.RESULTS The precision and the accuracy of improved method are good.CONCLUSION The problem of the old method was solved with this improved method and have a universal significance for the determination of ointment preparation.
2002, (3): 174-176.
Abstract:
OBJECTIVE To establish a methed for determining the concentration of kanamycin and dexamethson in DICA eye drops.METHED The concentration of kanamycin was determined by polarmetric analysis,ultravio specyro-photometry was employed for determination of dexamethson sodium phosphate.RESUITS:The average recovery of kana-mycin was 99.3%,RSD=0.40%(n=5);the average recovery of dexamethson sodium phosphate was 99.2%,RSD=0.20%(n=5).CONCLUSION It is a simple method for the quantitative analysis of compound preperation.
OBJECTIVE To establish a methed for determining the concentration of kanamycin and dexamethson in DICA eye drops.METHED The concentration of kanamycin was determined by polarmetric analysis,ultravio specyro-photometry was employed for determination of dexamethson sodium phosphate.RESUITS:The average recovery of kana-mycin was 99.3%,RSD=0.40%(n=5);the average recovery of dexamethson sodium phosphate was 99.2%,RSD=0.20%(n=5).CONCLUSION It is a simple method for the quantitative analysis of compound preperation.
2002, (3): 179-181.
Abstract:
OBJECTIVE To establish a new method to determin ondansetron in a natrium chloride infusion.METHLDS A reversed phase high performance liquid chromatography was employed. The mobile phase was composed of methanol and 0.02M KH2PO4 solution(58:42,pH=6.0).ODS was the stable phase.RESULTS Recovery was 100.14%.Between-day and Within-day precision was 0.41% and 0.54% respectively.CONCLUSION The method was rapid and correct.It is suitable for the determination of ondansetron in natrium chloride infusion.
OBJECTIVE To establish a new method to determin ondansetron in a natrium chloride infusion.METHLDS A reversed phase high performance liquid chromatography was employed. The mobile phase was composed of methanol and 0.02M KH2PO4 solution(58:42,pH=6.0).ODS was the stable phase.RESULTS Recovery was 100.14%.Between-day and Within-day precision was 0.41% and 0.54% respectively.CONCLUSION The method was rapid and correct.It is suitable for the determination of ondansetron in natrium chloride infusion.
2002, (3): 185-187.
Abstract:
OBJECTIVE To evaluate the economic effectiveness of different therapeutic regimens for essential hypertension.METHODS 106 patients with first and second phase hypertension and without serious heart,brain and kidney complication were divided into 3 groups.Each group was given different drugs,Agroup:captopril+simvastatin+instructions(38cases),Bgroup:betaloc+simvastatin+instructions(33cases),Cgroup:plendil+simvastatin+instructions(35c-ases).All the drugs were taken orally.The treatment time was 10wk.RESULTS The costs of A,B,C regimens were RMB 3596.50、3671 90、3885.40 Yuans and the effective rates were 86.84%、90.91%、97.14%,respectively.CONCLUSION According to the results of cost-effectiveness analysis,Bgroup:is the best choice among the three therapeutic reg-imens.
OBJECTIVE To evaluate the economic effectiveness of different therapeutic regimens for essential hypertension.METHODS 106 patients with first and second phase hypertension and without serious heart,brain and kidney complication were divided into 3 groups.Each group was given different drugs,Agroup:captopril+simvastatin+instructions(38cases),Bgroup:betaloc+simvastatin+instructions(33cases),Cgroup:plendil+simvastatin+instructions(35c-ases).All the drugs were taken orally.The treatment time was 10wk.RESULTS The costs of A,B,C regimens were RMB 3596.50、3671 90、3885.40 Yuans and the effective rates were 86.84%、90.91%、97.14%,respectively.CONCLUSION According to the results of cost-effectiveness analysis,Bgroup:is the best choice among the three therapeutic reg-imens.
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