2000 Vol. 18, No. 4
Display Method:
2000, (4): 195-196.
Abstract:
OBJECTIVE To compare the efficiency of cernilton and conprata pulean in the treatment of chronic prostatitis.METHODS One hundred and forty patients with chronic prostatitis were randomly divided into 2 groups.76 patients of treatment group(age 34a±13a)were treated with cernilton 1 tablet,po,bid,64 patients of control group(age 33a±15a)were treated with conprata pulean 2.0g,po,tid.All patients received 30 days treatment as a course.RESULTS The cure rates and total effective rates were 38.2% and 89.5% in the former group and 21.9% and 76.5% in the later group(P<0.05).Further more,the effects of cernilton on frequent micturition,underbelly ache and perineal ache were better than those of conprata pulean.CONCLUSION Cernilton has a better efficiency than conprata pulean in the treatment of chronic prostatitis.
OBJECTIVE To compare the efficiency of cernilton and conprata pulean in the treatment of chronic prostatitis.METHODS One hundred and forty patients with chronic prostatitis were randomly divided into 2 groups.76 patients of treatment group(age 34a±13a)were treated with cernilton 1 tablet,po,bid,64 patients of control group(age 33a±15a)were treated with conprata pulean 2.0g,po,tid.All patients received 30 days treatment as a course.RESULTS The cure rates and total effective rates were 38.2% and 89.5% in the former group and 21.9% and 76.5% in the later group(P<0.05).Further more,the effects of cernilton on frequent micturition,underbelly ache and perineal ache were better than those of conprata pulean.CONCLUSION Cernilton has a better efficiency than conprata pulean in the treatment of chronic prostatitis.
2000, (4): 209-211.
Abstract:
ORJECTIVE:To observe the antiinflammatory action of cobra(Naja naja)venom.METHODS Cobra venom was administered subcutaneously at doses of 2μg/kg,10μg/kg and 50μg/kg for 20 days after Freund complete adjuvant infection and intragastrically at dose of 25mg/kg for 7 days after cotton pellets planted in rats.RESULTS Cobra venom had no effect on the edema induced by adjuvant,but inhibited markedly granuloma information caused by cotton pellets in rats.CONCLUSION Cobra venom may be effective on synovitis.
ORJECTIVE:To observe the antiinflammatory action of cobra(Naja naja)venom.METHODS Cobra venom was administered subcutaneously at doses of 2μg/kg,10μg/kg and 50μg/kg for 20 days after Freund complete adjuvant infection and intragastrically at dose of 25mg/kg for 7 days after cotton pellets planted in rats.RESULTS Cobra venom had no effect on the edema induced by adjuvant,but inhibited markedly granuloma information caused by cotton pellets in rats.CONCLUSION Cobra venom may be effective on synovitis.
2000, (4): 212-215.
Abstract:
OBJECTIVE To Study the effects on myocardial ischemia re-perfusion injury treated by RCP on PC6 acupoint in rat.METHODS Wistar rats were randomized into groups of RCP acupoint group(A); i.m. RCP group(B);verapamil group(C) and NS control group(D).Myocardial ischemia re-perfusion injury models were set up.The hemodynamics parameters of the blood pressure(BP),left ventricular end systolic pressure(LVESP),left ventricular end diastolic pressure(LVEDP) and±dp/dtmax were recorded during the experiment.The intracelluar free calcium of the serum platelets and myocardial cells were measured with fluorescent probe,fura 2 established 2h after myocardial ischemia re-perfusion injury models.RESULTS In group A and group C,the concentration of calcium ion in myocardial cell were lower than that in group D(P<0.01).Group A was higher than group D in BP,LVESP and was lower inLVEDP,-dp/dtmax.Difference of the up-mentioned indexes between group A and group C appeared to be insignificant.CONCLUSION PC6 acupoint injection by RCP might increase myocardial contractility and prevent calcium overlodad in myocardial ischemia reperfusion injury rat.
OBJECTIVE To Study the effects on myocardial ischemia re-perfusion injury treated by RCP on PC6 acupoint in rat.METHODS Wistar rats were randomized into groups of RCP acupoint group(A); i.m. RCP group(B);verapamil group(C) and NS control group(D).Myocardial ischemia re-perfusion injury models were set up.The hemodynamics parameters of the blood pressure(BP),left ventricular end systolic pressure(LVESP),left ventricular end diastolic pressure(LVEDP) and±dp/dtmax were recorded during the experiment.The intracelluar free calcium of the serum platelets and myocardial cells were measured with fluorescent probe,fura 2 established 2h after myocardial ischemia re-perfusion injury models.RESULTS In group A and group C,the concentration of calcium ion in myocardial cell were lower than that in group D(P<0.01).Group A was higher than group D in BP,LVESP and was lower inLVEDP,-dp/dtmax.Difference of the up-mentioned indexes between group A and group C appeared to be insignificant.CONCLUSION PC6 acupoint injection by RCP might increase myocardial contractility and prevent calcium overlodad in myocardial ischemia reperfusion injury rat.
2000, (4): 216-217,218.
Abstract:
OBJECTIVE To discover the effect of molecular weight of PLA on the properties of rifampicin polylactic acid microspheres.METHODS Rifampicin polylactic acid microspheres were prepared by dispersion-solvent diffusion method.The microsphere size distribution and drug encapsulation efficiency were determined.The experiments on in vitro releasing property and stability of the microspheres were also carried out.RESULTS The relationship between molecular weight of PLA and the particle size distribution had not been seen. PLA of low molecular weight could decrease the drug encapsulation efficiency and accelerate the drug releasing rate.The experiments on stability showed that the microspheres were stable under 4℃or room temperature.Fusion and aggregation of the microspheres happened under 37℃ due to low glasstransition temperature of PLA polymer.CONCLUSION PLA microspheres of proper characteristics should be prepared from polylactic acid of certain molecular weight.
OBJECTIVE To discover the effect of molecular weight of PLA on the properties of rifampicin polylactic acid microspheres.METHODS Rifampicin polylactic acid microspheres were prepared by dispersion-solvent diffusion method.The microsphere size distribution and drug encapsulation efficiency were determined.The experiments on in vitro releasing property and stability of the microspheres were also carried out.RESULTS The relationship between molecular weight of PLA and the particle size distribution had not been seen. PLA of low molecular weight could decrease the drug encapsulation efficiency and accelerate the drug releasing rate.The experiments on stability showed that the microspheres were stable under 4℃or room temperature.Fusion and aggregation of the microspheres happened under 37℃ due to low glasstransition temperature of PLA polymer.CONCLUSION PLA microspheres of proper characteristics should be prepared from polylactic acid of certain molecular weight.
2000, (4): 223-224,229.
Abstract:
OBJECTIVE To develop a method of HPLC to determine the content of tanshinone ⅡA in compound tanshin tablet,METHODS Spherisorb C18 (5μ,200mm×4.6mm)was used,mobile phase wasmethanol-waver(85:15).The detection wanelength was 270nm.RESULTS The linear ranges of determination of tanshinone ⅡA was 8～180ng(r=0.9999),the average recovery rate was 99.5%.CONCLUTION:This method may be used for determination tanshinone ⅡA in compound tanshin tablet.
OBJECTIVE To develop a method of HPLC to determine the content of tanshinone ⅡA in compound tanshin tablet,METHODS Spherisorb C18 (5μ,200mm×4.6mm)was used,mobile phase wasmethanol-waver(85:15).The detection wanelength was 270nm.RESULTS The linear ranges of determination of tanshinone ⅡA was 8～180ng(r=0.9999),the average recovery rate was 99.5%.CONCLUTION:This method may be used for determination tanshinone ⅡA in compound tanshin tablet.
2000, (4): 225-227.
Abstract:
OBJECTIVE To determine the concentration of rifampicin in human serum by RP-HPLC.METHODS Serum was precipitated with centrifugation after add ed 4 times of methanol,and its super-stratum clear fluid was injected after filtration with 0.45μ micro-pore filter membrane.The method used Nova-Pak C18 column as chromatogram column,methanol-acetate buffer solution as flow phase,chlordiazepoxide as internal standard.The detection wavelength was 334nm.RESULTS The linear range of rifampicin was 1～25μg/ml.Average recovery was (100.9±4.2)%.Daily and daytime RSD were less than 4%.The lowest detection limit was 0.5μg/ml(the rate of signal and noise was greater than or equal to 3).CONCLUSION This method is simple,reliable and indicated for clinical monitoring.
OBJECTIVE To determine the concentration of rifampicin in human serum by RP-HPLC.METHODS Serum was precipitated with centrifugation after add ed 4 times of methanol,and its super-stratum clear fluid was injected after filtration with 0.45μ micro-pore filter membrane.The method used Nova-Pak C18 column as chromatogram column,methanol-acetate buffer solution as flow phase,chlordiazepoxide as internal standard.The detection wavelength was 334nm.RESULTS The linear range of rifampicin was 1～25μg/ml.Average recovery was (100.9±4.2)%.Daily and daytime RSD were less than 4%.The lowest detection limit was 0.5μg/ml(the rate of signal and noise was greater than or equal to 3).CONCLUSION This method is simple,reliable and indicated for clinical monitoring.
2000, (4): 230-231,232.
Abstract:
OBJECTIVE To study the quality standard of Gangang pills. METHODS Thin layer chromatography was used for simultaneously identification of Radix Astragali and Radix Salviae. The content of Ginsenoside Rgl in Radix Notoginseng was assayed by HPLC using YWG C18 column with acetonitrile-water(3:7, v/v)as the mobile. RESULTS The TLC identification was highly specific and the spots were clear and concentrated. An excellent linear relationship was obtained between the peak area and the concentration of Ginsenoside Rgl with the range of 4.05～24.30μg. The average recovery of Ginsenoside Rgl was 94.41% and the RSD was 3.04%. CONCLUSION This quality standard can be used for effectively controlling the quality of Gankang pills.
OBJECTIVE To study the quality standard of Gangang pills. METHODS Thin layer chromatography was used for simultaneously identification of Radix Astragali and Radix Salviae. The content of Ginsenoside Rgl in Radix Notoginseng was assayed by HPLC using YWG C18 column with acetonitrile-water(3:7, v/v)as the mobile. RESULTS The TLC identification was highly specific and the spots were clear and concentrated. An excellent linear relationship was obtained between the peak area and the concentration of Ginsenoside Rgl with the range of 4.05～24.30μg. The average recovery of Ginsenoside Rgl was 94.41% and the RSD was 3.04%. CONCLUSION This quality standard can be used for effectively controlling the quality of Gankang pills.
2000, (4): 250-254,244.
Abstract:
OBJECTIVE To review the principles of therapeutic drug monitoring (TDM)and the role of analytical techniques in TDM.METHODS The content included ranges of monitored drugs,sampling requirements and analytical aspects.RESULTS This article explained the criteria for undertaking drug level monitoring and the requirements of sampling,compared techniques of chromatographic and immunoassay.CONCLUSION For reliable results of TDM,it is necessary to implement good quality control of the assay to ensure that it continues to work satisfactorily.
OBJECTIVE To review the principles of therapeutic drug monitoring (TDM)and the role of analytical techniques in TDM.METHODS The content included ranges of monitored drugs,sampling requirements and analytical aspects.RESULTS This article explained the criteria for undertaking drug level monitoring and the requirements of sampling,compared techniques of chromatographic and immunoassay.CONCLUSION For reliable results of TDM,it is necessary to implement good quality control of the assay to ensure that it continues to work satisfactorily.
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