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类风湿性关节炎的治疗药物研究进展

王静,  赵庆杰,  卓小斌,  姜云云,  叶光明

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文章导航 > 药学实践与服务  > 2019 >  37(6): 485-490
王静, 赵庆杰, 卓小斌, 姜云云, 叶光明. 类风湿性关节炎的治疗药物研究进展[J]. 药学实践与服务, 2019, 37(6): 485-490. doi: 10.3969/j.issn.1006-0111.2019.06.002
引用本文: 王静, 赵庆杰, 卓小斌, 姜云云, 叶光明. 类风湿性关节炎的治疗药物研究进展[J]. 药学实践与服务, 2019, 37(6): 485-490. doi: 10.3969/j.issn.1006-0111.2019.06.002
shu
WANG Jing, ZHAO Qinjie, ZHUO Xiaobin, JIANG Yunyun, YE Guangming. Research progress on therapeutic drugs for rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 485-490. doi: 10.3969/j.issn.1006-0111.2019.06.002
Citation: WANG Jing, ZHAO Qinjie, ZHUO Xiaobin, JIANG Yunyun, YE Guangming. Research progress on therapeutic drugs for rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 485-490. doi: 10.3969/j.issn.1006-0111.2019.06.002
shu

类风湿性关节炎的治疗药物研究进展

doi: 10.3969/j.issn.1006-0111.2019.06.002
  • 1.

    安徽医科大学解放军98临床学院, 浙江 湖州 230032

  • 2.

    海军军医大学药学院, 上海 200433

  • 3.

    解放军101医院, 江苏 无锡 214044

Research progress on therapeutic drugs for rheumatoid arthritis

  • 1.

    Huzhou Clinical College of Auhui medical University/No. 98 Hospital of PLA, Huzhou 230032, China

  • 2.

    School of Pharmacy, Naval Medical University, Shanghai 200433, China

  • 3.

    No. 101 Hospital of PLA, Wuxi 214044, China

  • 摘要: 类风湿性关节炎（RA）作为一种常见的自身免疫性疾病，临床表现为关节损伤和滑膜炎症。通过阐述临床RA药物的治疗机制和作用靶点，综述了两大类RA药物，包括小分子合成类RA药物和大分子生物RA药物（肿瘤坏死因子α抑制剂、T、B细胞抑制剂、细胞因子受体抑制剂、靶点RANKL生物制剂以及靶点粒细胞-巨噬细胞集落刺激因子生物制剂），通过结合RA病理机制重点对这两大类药物的治疗机制和作用靶点进行阐明介绍，同时概述了治疗类风湿性关节炎的最新治疗靶点，为类风湿性关节炎患者的治疗提供潜在新方向。
    Abstract: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by joint damage and synovial inflammation.Two major classes of RA drugs,including small molecule synthetic RA drugs and macromolecular biological RA drugs (TNF inhibitors、B cell inhibitors、T cell inhibitors、IL inhibitors、target RANKL biologics、target GM-CSF biologics) were reviewed in this paper,focusing on the therapeutic mechanisms of these two classes of drugs.In addition the latest therapeutic target for rheumatoid arthritis was also summarized,which provided a potential new direction for the treatment of patients with rheumatoid arthritis.
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  • 收稿日期:  2019-06-03
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类风湿性关节炎的治疗药物研究进展

doi: 10.3969/j.issn.1006-0111.2019.06.002
  • 1. 安徽医科大学解放军98临床学院, 浙江 湖州 230032
  • 2. 海军军医大学药学院, 上海 200433
  • 3. 解放军101医院, 江苏 无锡 214044
  • 收稿日期: 2019-06-03
  • 修回日期: 2019-10-09

摘要: 类风湿性关节炎（RA）作为一种常见的自身免疫性疾病，临床表现为关节损伤和滑膜炎症。通过阐述临床RA药物的治疗机制和作用靶点，综述了两大类RA药物，包括小分子合成类RA药物和大分子生物RA药物（肿瘤坏死因子α抑制剂、T、B细胞抑制剂、细胞因子受体抑制剂、靶点RANKL生物制剂以及靶点粒细胞-巨噬细胞集落刺激因子生物制剂），通过结合RA病理机制重点对这两大类药物的治疗机制和作用靶点进行阐明介绍，同时概述了治疗类风湿性关节炎的最新治疗靶点，为类风湿性关节炎患者的治疗提供潜在新方向。

English Abstract

王静, 赵庆杰, 卓小斌, 姜云云, 叶光明. 类风湿性关节炎的治疗药物研究进展[J]. 药学实践与服务, 2019, 37(6): 485-490. doi: 10.3969/j.issn.1006-0111.2019.06.002
引用本文: 王静, 赵庆杰, 卓小斌, 姜云云, 叶光明. 类风湿性关节炎的治疗药物研究进展[J]. 药学实践与服务, 2019, 37(6): 485-490. doi: 10.3969/j.issn.1006-0111.2019.06.002
shu
WANG Jing, ZHAO Qinjie, ZHUO Xiaobin, JIANG Yunyun, YE Guangming. Research progress on therapeutic drugs for rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 485-490. doi: 10.3969/j.issn.1006-0111.2019.06.002
Citation: WANG Jing, ZHAO Qinjie, ZHUO Xiaobin, JIANG Yunyun, YE Guangming. Research progress on therapeutic drugs for rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 485-490. doi: 10.3969/j.issn.1006-0111.2019.06.002
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