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抗骨质疏松治疗药物研究的新进展

贾文斌,  刘超,  邹燕

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文章导航 > 药学实践与服务  > 2017 >  35(6): 490-494,542
贾文斌, 刘超, 邹燕. 抗骨质疏松治疗药物研究的新进展[J]. 药学实践与服务, 2017, 35(6): 490-494,542. doi: 10.3969/j.issn.1006-0111.2017.06.003
引用本文: 贾文斌, 刘超, 邹燕. 抗骨质疏松治疗药物研究的新进展[J]. 药学实践与服务, 2017, 35(6): 490-494,542. doi: 10.3969/j.issn.1006-0111.2017.06.003
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JIA Wenbin, LIU Chao, ZOU Yan. Research progress on drugs in osteoporosis therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 490-494,542. doi: 10.3969/j.issn.1006-0111.2017.06.003
Citation: JIA Wenbin, LIU Chao, ZOU Yan. Research progress on drugs in osteoporosis therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 490-494,542. doi: 10.3969/j.issn.1006-0111.2017.06.003
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抗骨质疏松治疗药物研究的新进展

doi: 10.3969/j.issn.1006-0111.2017.06.003
  • 1.

    海军青岛第一疗养院药剂科, 山东 青岛 266071

  • 2.

    第二军医大学药学院有机化学教研室, 上海 200433

Research progress on drugs in osteoporosis therapy

  • 1.

    Department of Pharmacy, Qingdao First Sanatorium of Navy Military, Qingdao 266071, China

  • 2.

    Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 骨质疏松是一种常见的全身性骨代谢疾病，主要表现为骨密度与骨量的下降，从而导致继发性骨折。目前，随着其发病率不断增高，骨质疏松已经成为一个世界范围的健康问题和当前医学的研究热点。骨吸收抑制剂主要作用于破骨细胞，通过抑制破骨细胞分化成熟，减少骨吸收；骨形成促进剂主要作用于成骨细胞，激活其骨形成功能，并且有重建骨组织的效应；骨矿化物是防治骨质疏松的基础药物，包括钙剂和维生素D；解偶联剂种类较为单一，代表药物为雷尼酸锶。主要对以上四大类抗骨质疏松药物的研究进展进行介绍。
    Abstract: Osteoporosis (OP) is a systemic bone metabolism disease characterized by a systemic impairment of bone mass, strength, and microarchitecture, which will be result in increasing the propensity of fragility fractures. In recent years, OP becomes a worldwide health problem and a hotspot in medical research due to its increasing incidence. Anti-resorptive drugs inhibit osteoclast differentiation and maturation in order to reduce bone resorption; Bone-anabolic drugs promote the bone formation function of osteoblast and reconstruct bone tissue; Bone mineralization-acceleration drugs are the basic material for prevention and treatment of osteoporosis, including calcium and vitamin D; Strontium ranelate is the representative drug of uncoupling agents. In this paper, the current progress of osteoporosis treatments were reviewed including these proposed drugs.
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出版历程
  • 收稿日期:  2017-08-24
  • 修回日期:  2017-10-16

抗骨质疏松治疗药物研究的新进展

doi: 10.3969/j.issn.1006-0111.2017.06.003
  • 1. 海军青岛第一疗养院药剂科, 山东 青岛 266071
  • 2. 第二军医大学药学院有机化学教研室, 上海 200433
  • 收稿日期: 2017-08-24
  • 修回日期: 2017-10-16

摘要: 骨质疏松是一种常见的全身性骨代谢疾病，主要表现为骨密度与骨量的下降，从而导致继发性骨折。目前，随着其发病率不断增高，骨质疏松已经成为一个世界范围的健康问题和当前医学的研究热点。骨吸收抑制剂主要作用于破骨细胞，通过抑制破骨细胞分化成熟，减少骨吸收；骨形成促进剂主要作用于成骨细胞，激活其骨形成功能，并且有重建骨组织的效应；骨矿化物是防治骨质疏松的基础药物，包括钙剂和维生素D；解偶联剂种类较为单一，代表药物为雷尼酸锶。主要对以上四大类抗骨质疏松药物的研究进展进行介绍。

English Abstract

贾文斌, 刘超, 邹燕. 抗骨质疏松治疗药物研究的新进展[J]. 药学实践与服务, 2017, 35(6): 490-494,542. doi: 10.3969/j.issn.1006-0111.2017.06.003
引用本文: 贾文斌, 刘超, 邹燕. 抗骨质疏松治疗药物研究的新进展[J]. 药学实践与服务, 2017, 35(6): 490-494,542. doi: 10.3969/j.issn.1006-0111.2017.06.003
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JIA Wenbin, LIU Chao, ZOU Yan. Research progress on drugs in osteoporosis therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 490-494,542. doi: 10.3969/j.issn.1006-0111.2017.06.003
Citation: JIA Wenbin, LIU Chao, ZOU Yan. Research progress on drugs in osteoporosis therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 490-494,542. doi: 10.3969/j.issn.1006-0111.2017.06.003
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