Clinical observation of piperacillin/tazobactam's optimized regimen formulated by T >MIC% for 59 patients with P.aeruginosa infection
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摘要: 目的 观察T> MIC%指导优化的哌拉西林/他唑巴坦抗铜绿假单胞菌感染方案的疗效。 方法 选择2015年1-4月病原学确诊为铜绿假单胞菌感染且对哌拉西林/他唑巴坦敏感的住院患者59例，治疗前随机分为对照组和试验组。对照组采用哌拉西林/他唑巴坦4.5 g，q6 h的方案；试验组采用哌拉西林/他唑巴坦4.5 g，q12 h的方案。2组均联合阿米卡星15 mg/（kg·d），qd的方案共同治疗。其他治疗方法相同。 结果 2组患者临床治疗有效率和总住院时间相当、细菌清除率和不良反应发生率相似、治疗前后CRP和APACHE Ⅱ评分无差异。 结论 依据T> MIC%指导优化的哌拉西林/他唑巴坦抗铜绿假单胞菌感染方案安全、有效、可行。
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关键词:
- 哌拉西林/他唑巴坦 /
- 铜绿假单胞菌 /
- 药动学/药效学理论 /
- 血药浓度大于最低抑菌浓度的持续时间
Abstract: Objective To observe the treatment efficacy of piperacillin/tazobactam regime for P.aeruginosa infection formulated by the method of the ratio of T above MIC (T >MIC%). Methods 59 hospitalized patients with P.aeruginosa infection were diagnosed by etiological diagnosis which was sensitive to piperacillin/tazobactam from Jan. to April.2015. Before treatment, all patients were randomly divided into the control group and the test group. Patients in the control group were treated with 4.5 g piperacillin/tazobactam once and repeated every six hours. Patients in test group were treated with 4.5 g piperacillin/tazobactam once and repeated every twelve hours. The two groups were injected by 15 mg/kg amikacin once a day based on the above program. The other treatments were kept to be same. Results Between the two groups, the clinical efficiency rate and total hospital stay were equivalent, bacterial clearance rate and incidence of adverse reactions were similar, there were no difference between CRP and APACHE Ⅱ score before and after treatment. Conclusion The regime of piperacillin/tazobactam for P.aeruginosa infection formulated by the method of the ratio of T above MIC (T >MIC%)was safe, effective and feasible. -
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