石蒜碱2-位羟基构型翻转的探索

赵增; 许旭升; 孙青龑; 陈浩; 柳润辉

doi:10.3969/j.issn.1006-0111.2016.06.008

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石蒜碱2-位羟基构型翻转的探索

赵增, 许旭升, 孙青龑, 陈浩, 柳润辉

文章导航 > 药学实践与服务 > 2016 > 34(6): 511-515

赵增, 许旭升, 孙青龑, 陈浩, 柳润辉. 石蒜碱2-位羟基构型翻转的探索[J]. 药学实践与服务, 2016, 34(6): 511-515. doi: 10.3969/j.issn.1006-0111.2016.06.008

引用本文:

赵增, 许旭升, 孙青龑, 陈浩, 柳润辉. 石蒜碱2-位羟基构型翻转的探索[J]. 药学实践与服务, 2016, 34(6): 511-515. doi: 10.3969/j.issn.1006-0111.2016.06.008

ZHAO Zeng, XU Xusheng, SUN Qingyan, CHEN Hao, LIU Runhui. Configuration inversion of C-2-hydroxy in lycorine[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 511-515. doi: 10.3969/j.issn.1006-0111.2016.06.008

Citation:

ZHAO Zeng, XU Xusheng, SUN Qingyan, CHEN Hao, LIU Runhui. Configuration inversion of C-2-hydroxy in lycorine[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 511-515. doi: 10.3969/j.issn.1006-0111.2016.06.008

石蒜碱2-位羟基构型翻转的探索

doi: 10.3969/j.issn.1006-0111.2016.06.008

第二军医大学药学院天然药物化学教研室, 上海 200433

Configuration inversion of C-2-hydroxy in lycorine

Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 目的对石蒜碱2-位羟基构型翻转的研究，为化合物asiaticumine B的半合成提供基础。方法通过氧化再还原的方法，探索石蒜碱2-位羟基构型的翻转。结果完成了石蒜碱2-位羟基构型翻转，总收率49%。结论探索出一种高效便捷的对石蒜碱2-位羟基构型翻转的方法。
- 石蒜碱 /
- asiaticumineB /
- 构型翻转
Abstract: Objective Study configuration inversion of C-2-hydroxy in lycorine to provide a foundation for semi-synthesis of asiaticumine B. Methods Use instrumental analyses to explore the C-2-hydroxy configuration through oxidation and reduction reactions. Results Accomplished configuration inversion of C-2-hydroxy in lycorine with 49% yield. Conclusion We identified a convenient and efficient method for the configuration inversion of C 2-hydroxy in lycorine.
- lycorine /
- asiaticumine B /
- configuration inversion

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