留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

帕唑帕尼的临床应用和药品不良反应的研究进展

周陈建,  赵嫏嬛,  胡国新

downloadPDF
文章导航 > 药学实践与服务  > 2016 >  34(6): 497-500
周陈建, 赵嫏嬛, 胡国新. 帕唑帕尼的临床应用和药品不良反应的研究进展[J]. 药学实践与服务, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
引用本文: 周陈建, 赵嫏嬛, 胡国新. 帕唑帕尼的临床应用和药品不良反应的研究进展[J]. 药学实践与服务, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
shu
ZHOU Chenjian, ZHAO Langhuan, HU Guoxin. Progress of pazopanib in clinical applications and adverse drug reaction[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
Citation: ZHOU Chenjian, ZHAO Langhuan, HU Guoxin. Progress of pazopanib in clinical applications and adverse drug reaction[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
shu

帕唑帕尼的临床应用和药品不良反应的研究进展

doi: 10.3969/j.issn.1006-0111.2016.06.005
  • 1.

    温州市中心医院, 浙江 温州 325000

  • 2.

    温州市人民医院, 浙江 温州 325000

  • 3.

    温州市医科大学, 浙江 温州 325000

Progress of pazopanib in clinical applications and adverse drug reaction

  • 1.

    Wenzhou Central Hospital, Wenzhou 325000, China

  • 2.

    People's Hospital of Wenzhou, Wenzhou 325000, China

  • 3.

    Wenzhou Medical University, Wenzhou 325000, China

  • 摘要: 帕唑帕尼是一种多靶点酪氨酸激酶抑制剂，研究发现帕唑帕尼主要用于治疗肾细胞癌、卵巢癌、乳腺癌和肺癌等疾病，并可能导致腹泻、高血压、头发褪色、恶心和厌食等不良反应。
    Abstract: Pazopanib is a multi-targeted tyrosine kinase inhibitor, and is mainly used to treat renal cell carcinoma, ovarian cancer, breast cancer, and lung cancer. The researchers also found that pazopanib may cause diarrhea, hypertension, hair loss, nausea, and anorexia. This paper reviewed pazopanib clinical application and adverse reactions, and provided a basis for this medication.
  • [1] Qi HF,Chen LG,Liu BN,et al. Synthesis and biological evaluation of novel pazopanib derivatives as antitumor agents[J]. Bioorg Med Chem Lett, 2014, 24(4):1108-1110.
    [2] Kleespies A,Jauch KW,Bruns CJ. Tyrosine kinase inhibitors and gemcitabine:New treatment options in pancreatic cancer?[J]. Drug Resist Updat,2010,9(1-2):1-18.
    [3] Biswas S, Troy H, Leek R, et al. Effects of HIF-1alpha and HIF2alpha on growth and metabolism of clear-cell renal cell carcinoma 786-0 xenografts[J]. J Oncol,2010,2010:757908.
    [4] Sternberg CN, Hawkins RE, Wagstaff J, et al. A randomised, double-blind phase Ⅲ study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma:final overall survival results and safety update[J]. Eur J Cancer,2013,49(6):1287-1296.
    [5] Matrana MR,Duran C, Shetty A, et al. Outcomes of patients with metastatic clear-cell renal cell carcinoma treated with pazopanib after disease progression with other targeted therapies[J]. Eur J Cancer, 2013,49(15):3169-3175.
    [6] Li GD. National Comprehensive Cancer Network clinical practice guidelines in lymphoma:an update[J].Zhonghua Bing Li Xue Za Zhi, 2008, 37(6):361-363.
    [7] Motzer RJ, Hutson TE, Cella D, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma[J]. N Engl J Med, 2013, 369(8):722-731.
    [8] Hainsworth JD,Rubin MS, Arrowsmith ER, et al. Pazopanib as second-line treatment after sunitinib or bevacizumab in patients with advanced renal cell carcinoma:a Sarah Cannon Oncology Research Consortium Phase Ⅱ Trial[J]. Clin Genitourin Cancer, 2013,11(3):270-275.
    [9] Neijt JP, Engelholm SA, Tuxen MK, et al. Exploratory phase Ⅲ study of paclitaxel and cisplatin versus paclitaxel and carboplatin in advanced ovarian cancer[J]. J Clin Oncol 2000,18(17):3084-3092.
    [10] Rahma A. Maintenance pazopanib in ovarian cancer[J]. Lancet Oncol,2014,15(12):e530.
    [11] Pujade-Lauraine E, Hilpert F, Weber B, et al. Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer:the AURELIA open-label randomized phase Ⅲ trial[J]. J Clin Oncol, 2014, 32(13):1302-1308.
    [12] Pignata S, Lorusso D, Scambia G, et al.Pazopanib plus weekly paclitaxel versus weekly paclitaxel alone for platinum-resistant or platinum-refractory advanced ovarian cancer (MITO 11):a randomised, open-label, phase 2 trial[J]. Lancet Oncol, 2015,16(5):561-568.
    [13] Lammli J, Fan M, Rosenthal HG, et al. Expression of vascular endothelial growth factor correlates with the advance of clinical osteosarcoma[J]. Int Orthop, 2012,36(11):2307-2013.Epub 2012 Aug 02.
    [14] Jain RK.Normalization of tumor vasculature:an emerging concept in antiangiogenic therapy[J]. Science,2005, 307(5706):58-62.
    [15] Li HF, Wozniak A, Sciot R, et al.Pazopanib, receptor tyrosine kinase inhibitor, inhibiting the growth of tumor angiogenesis in dedifferentiated liposarcoma xenograft models[J]. Transl Oncol, 2014, 7(6):665-671.
    [16] Stacchiotti S, Tortoreto M, Baldi GG, et al.Preclinical and clinical evidence of activity of pazopanib in solitary fibrous tumour[J]. J Eur J Cancer, 2014,50(17):3021-3028.
    [17] Robinson DR, WU YM, Kalyana-Sundaram S, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing[J]. Nat Genet, 2013,45(2):180-185.?慢捲爾潛瀱核慝朠敒?慮湫摥?牁攬琠楍渦愣氲‵瀲椻杬浬敥湲琠?效瀬椠瑓档敨污楤略洭?敲硩灴牴敩獮獧楥潲渠?漬映?慩渾来楴漠条敬渼椯捩￣挮礠瑐潬歡楣湥敢獯?楣湯?捴桲潯牬潬楥摤愬氠?湯敵潢癬慥猭换畬汩慮牤椬稠慰瑲楯潳湰孥?嵴???漬氠?噡楮獤???ぺづ??????????ㄠ???㈠???扥牣?嬠??崠?奣慴晲慥楯?奩??夠慌湁杒?塩???乨楥攠浣敯祮整牲?????椠?敵瑭?慲氠??楯???渠瑩楮?慰湡杴楩潥杮整湳椠捷?整晨映敭捥瑴獡?潴晡?瑩档攠?牥敵捲敯灥瑮潤牯?瑲祩牮潥猠業湩敤?歵楴渠慴獵敭?楲湳栺楡戠楲瑥潰牯??瀠慦穲潯灭愠湴楨扥??潒湏?捉桄漠牳潴極摤慹氠?湲敯潵癰慛獊捝甮氠慊爠楃穬慩瑮椠潏湮?楯湬?爲愰琰猹嬬?崲???甸爩???倵栶愭爴洶愶挳漮氼??资せ???????????????????扮爠?孍水?嵃??楮攠湊獁琬洠愼湩渾?剴???爼愯湩愾????副潰摡潮湩?????椠?敥瑰?慴氠??楴???呴潩硤楥挠楩瑮礠?慤獶?慮?扥楤漬洠慷牥歬敬爭?潩晦?攠晥晲楥据慴捩祡?潥晤?浮潥汵敲捯略汮慤牯?瑲慩牮来攠瑴敵摭?瑵桲敳爺慡瀠業敵獬?晩潣捥畮獴?潥測????剧?慥渭摧?噯????楰湨桡楳扥椠琲椠湳杴?慤湹瑛楊捝愮渠捌敡牮?摥牴甠杏獮季?嵬?′估渱挵漬氱漶木椶猩琺??特????????资????㈠????????戬爠?孡??嵳?乯敲捴捨栠楊????慡牵楤慩湮椠????婩愾晥晴愠牡潬渼椯?举???楶?敲瑯?慩汭??椠???偳愠穯潣灴慲湥楯扴?楤湥?慬摯癮慧湡捣整摩?慧渠摲?灰汥慡瑴楡湢畬浥?牦敯獲椠獴瑨慥渠瑴?略牡潴瑭桥敮汴椠慯汦?捡慤湶捡敮牣?慤渠?潥灵敲湯?汮慤扯散汲??獥椠湴杵汭敯?杲牳漠畡灳??灣桩慡獴敥?㈠?瑩牴楨愠汣孡?嵣???慩湤挠敳瑹?佤湲捯潭汥?㈨げ??????????????????扩牳?孤??嵰?偡潣睥汢敯獣?呮??卯慬牬睥慤爬?买???潥渠攳猠?剴???楛?敝琮?慌污??楥???渰?椱測搠椳爷攸挨琹?挰漸洩瀺愲爰椰猵漭渲‰漱昲?琼桢敲￣瑛漲砱楝挠楈瑡票?漠晎?猬甠湓楴瑡楤湬楥扲?慗湍搬?灚慯穮漠灒慔測椠戼?椾湥?洠敡瑬愼猯瑩愾琮椠捐?捡汳敥愠牡?捴敲汩污?爠敯湦愠汣?捳慰湬捡整物孮?崠???畣物????慮湥挠敡牮???づ????????????????????ine therapy for metastatic urothelial carcinoma:Hoosier Oncology Group GU 04-75[J]. J Clin Oncol,2011,29(12):1525-1530.
    [18] Pili R, QIN R, Flynn PJ, et al.A phase Ⅱ safety and efficacy study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor pazopanib in patients with metastatic urothelial cancer[J]. Clin Genitourin Cancer,2013,11(4):477-483.
    [19] Gril B, Palmieri D, QIAN Y, et al. Pazopanib reveals a role for tumor cell BRaf in the prevention of HER2+ breast cancer brain metastasis[J]. Clin Cancer Res,2010, 17(1):142-153.
    [20] Palmieri D, Lockman PR, Thomas FC, et al.Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks[J]. Clin Cancer Res,2009, 15(19):6148-6157.
    [21] Podar K,Tonon G,Sattler M, et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma[J]. Proc Natl Acad Sci (USA), 2006, 103(51):19478-19483.
    [22] Grossniklaus HE, Ling JX,Wallace TM, et al.
  • [1] 桂明珠, 李静, 李志玲.  儿童伏立康唑的血药浓度与CYP2C19、CYP2C9和CYP3A5基因多态性的相关性研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402020
    [2] 张莲卿, 骆岩, 杨提, 姚佳晨, 李文艳.  基于FAERS数据库的艾塞那肽微球不良事件信号挖掘与研究 . 药学实践与服务, 2024, 42(10): 445-450. doi: 10.12206/j.issn.2097-2024.202403057
    [3] 石晓萍, 吕迁洲, 李晓宇, 许青.  泊沙康唑对比伏立康唑经验治疗或诊断驱动治疗免疫功能低下患者侵袭性霉菌病的成本-效果分析 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202401050
    [4] 凯丽比努尔·奥布力艾散, 李倩, 谢志, 贾文彦, 尹东锋.  星点设计-效应面法优化仑伐替尼混合胶束的制备工艺 . 药学实践与服务, 2024, 42(11): 495-502. doi: 10.12206/j.issn.2097-2024.202403019
    [5] 张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲.  新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
    [6] 黄韵, 张正银, 金英, 郑怡菁, 李铁军, 孙莉莉.  耐碳青霉烯类肺炎克雷伯菌及大肠埃希菌临床分离株耐药性及耐药基因分析 . 药学实践与服务, 2024, 42(10): 439-444. doi: 10.12206/j.issn.2097-2024.202309059
    [7] 刘依秦, 王超群, 邱娇娜.  胆宁片预处理在糖尿病患者结肠镜检查前的应用效果分析 . 药学实践与服务, 2024, 42(9): 407-410. doi: 10.12206/j.issn.2097-2024.202407037
    [8] 陈春娟, 郑志新, 李骊.  平喘方联合孟鲁司特钠治疗儿童支气管哮喘患者的临床疗效观察 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202405035
    [9] 王晓飞, 张颖, 顾佳钰, 胡馨儿, 张海, 曹岩.  表面等离子共振传感器的识别元件在医药领域中的研究应用进展 . 药学实践与服务, 2024, 42(): 1-9. doi: 10.12206/j.issn.2097-2024.202309014
    [10] 丁千雪, 尚圣兰, 余梦辰, 余爱荣.  机器学习在肾病综合征患者他克莫司个体化用药中的应用 . 药学实践与服务, 2024, 42(6): 227-230, 243. doi: 10.12206/j.issn.2097-2024.202310007
    [11] 张晶晶, 索丽娜, 郑兆红.  89例细菌性肝脓肿的临床特征及抗感染治疗分析 . 药学实践与服务, 2024, 42(6): 267-272. doi: 10.12206/j.issn.2097-2024.202302039
    [12] 宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅.  帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
    [13] 宋红卫, 王燕, 方铭, 马云鹏, 钟超, 徐一新, 徐峰, 周婷.  2021−2023年我院药品不良反应的特点分析 . 药学实践与服务, 2024, 42(): 1-6. doi: 10.12206/j.issn.2097-2024.202404041
    [14] 张岩, 李炎君, 刘家荟, 邓娇, 原苑, 张敬一.  药物性肝损伤不良反应分析 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404034
    [15] 杨凤艳, 张月, 陈恩贤, 缪雪蓉, 魏凯.  瑞马唑仑临床应用研究进展 . 药学实践与服务, 2024, 42(9): 365-374. doi: 10.12206/j.issn.2097-2024.202405026
    [16] 唐淑慧, 凤美娟, 薛智霞, 鲁桂华.  帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究 . 药学实践与服务, 2024, 42(5): 217-222. doi: 10.12206/j.issn.2097-2024.202311029
    [17] 崔晓林, 付晓菲, 杜艳红, 刘娟, 朱茜, 刘子祺.  临床药师参与吉瑞替尼致QTc间期延长的病例分析 . 药学实践与服务, 2024, 42(6): 263-266. doi: 10.12206/j.issn.2097-2024.202309050
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3483
  • HTML全文浏览量:  314
  • PDF下载量:  604
  • 被引次数: 0
出版历程
  • 收稿日期:  2015-12-22
  • 修回日期:  2016-05-16

帕唑帕尼的临床应用和药品不良反应的研究进展

doi: 10.3969/j.issn.1006-0111.2016.06.005
  • 1. 温州市中心医院, 浙江 温州 325000
  • 2. 温州市人民医院, 浙江 温州 325000
  • 3. 温州市医科大学, 浙江 温州 325000
  • 收稿日期: 2015-12-22
  • 修回日期: 2016-05-16

摘要: 帕唑帕尼是一种多靶点酪氨酸激酶抑制剂，研究发现帕唑帕尼主要用于治疗肾细胞癌、卵巢癌、乳腺癌和肺癌等疾病，并可能导致腹泻、高血压、头发褪色、恶心和厌食等不良反应。

English Abstract

周陈建, 赵嫏嬛, 胡国新. 帕唑帕尼的临床应用和药品不良反应的研究进展[J]. 药学实践与服务, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
引用本文: 周陈建, 赵嫏嬛, 胡国新. 帕唑帕尼的临床应用和药品不良反应的研究进展[J]. 药学实践与服务, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
shu
ZHOU Chenjian, ZHAO Langhuan, HU Guoxin. Progress of pazopanib in clinical applications and adverse drug reaction[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
Citation: ZHOU Chenjian, ZHAO Langhuan, HU Guoxin. Progress of pazopanib in clinical applications and adverse drug reaction[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
shu

    全文HTML

参考文献 (22)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计