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辐射所致肠道损伤中环氧酶作用的研究进展

陶玉龙,  杨宏,  陶霞

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文章导航 > 药学实践与服务  > 2016 >  34(3): 193-195
陶玉龙, 杨宏, 陶霞. 辐射所致肠道损伤中环氧酶作用的研究进展[J]. 药学实践与服务, 2016, 34(3): 193-195. doi: 10.3969/j.issn.1006-0111.2016.03.001
引用本文: 陶玉龙, 杨宏, 陶霞. 辐射所致肠道损伤中环氧酶作用的研究进展[J]. 药学实践与服务, 2016, 34(3): 193-195. doi: 10.3969/j.issn.1006-0111.2016.03.001
shu
TAO Yulong, YANG Hong, TAO Xia. Role of cyclooxygenases in radiation enteropathy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 193-195. doi: 10.3969/j.issn.1006-0111.2016.03.001
Citation: TAO Yulong, YANG Hong, TAO Xia. Role of cyclooxygenases in radiation enteropathy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 193-195. doi: 10.3969/j.issn.1006-0111.2016.03.001
shu

辐射所致肠道损伤中环氧酶作用的研究进展

doi: 10.3969/j.issn.1006-0111.2016.03.001

  • 第二军医大学附属长征医院药学部, 上海 200003

基金项目: 上海市科学技术委员会科研计划项目(12401900704)

Role of cyclooxygenases in radiation enteropathy

  • Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

  • 摘要: 胃肠道对辐射高度敏感;防治辐射所致的胃肠道组织损伤一直是放射生物学领域探究的热点。以往研究表明,环氧酶对辐射引起的肠组织损伤有重要的保护作用。笔者就环氧酶在辐射所致肠道损伤中的作用及其机制做一综述。
    Abstract: Gastrointestinal tract is one of the most sensitive organs exposed to ionizing radiation. Radiation enteropathy is a hot topic in radiobiological field. Cumulative evidences demonstrated that cyclooxygenases (COXs) might contribute substantially to attenuating intestinal damage provoked by irradiation. The role of cyclooxygenases in radiation-induced intestinal damage was reviewed in this paper.
  • [1] Williams JP, Brown SL, Georges GE, et al. Animal models for medical countermeasures to radiation exposure[J]. Radiat Res, 2010,173(4):557-578.
    [2] Hauer-Jensen M, Denham JW, Andreyev HJ. Radiation enteropathy- -pathogenesis, treatment and prevention[J]. Nat Rev Gastroenterol Hepatol, 2014,11(8):470-479.
    [3] Theis VS, Sripadam R, Ramani V, et al. Chronic radiation enteritis[J]. Clin Oncol (R Coll Radiol), 2010,22(1):70-83.
    [4] Singh VK, Newman VL, Berg AN, et al. Animal models for acute radiation syndrome drug discovery[J]. Expert Opin Drug Discov, 2015,10(5):497-517.
    [5] Houchen CW, Stenson WF, Cohn SM. Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury[J]. Am J Physiol Gastrointest Liver Physiol, 2000,279(5):G858-865.
    [6] Ciorba MA, Riehl TE, Rao MS, et al. Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner[J]. Gut, 2012,61(6):829-838.
    [7] Vance DE, Vance JE. Biochemistry of lipids, lipoproteins and membranes[M]. 5th ed. San Diego:Elsevier, 2008:332-361.
    [8] Smith WL, Song I. The enzymology of prostaglandin endoperoxide H synthases-1 and -2[J]. Prostaglandins Other Lipid Mediat, 2002,(68-69):115-128.
    [9] Jackson LM, Wu KC, Mahida YR, et al. Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa[J]. Gut, 2000,47(6):762-770.
    [10] Zhang Z, Andoh A, Inatomi O, et al. Interleukin-17 and lipopolysaccharides synergistically induce cyclooxygenase-2 expression in human intestinal myofibroblasts[J]. J Gastroenterol Hepatol, 2005,20(4):619-627.
    [11] Brown SL, Riehl TE, Walker MR, et al. Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury[J]. J Clin Invest, 2007,117(1):258-269.
    [12] Hall E J. Radiobiology for the radiologist[M]. 5th ed. USA:Lippincott Williams & Wilkins, 2000:32-66.
    [13] Shadad AK, Sullivan FJ, Martin JD, et al. Gastrointestinal radiation injury:symptoms, risk factors and mechanisms[J]. World J Gastroenterol, 2013,19(2):185-198.
    [14] Barker N. Adult intestinal stem cells:critical drivers of epithelial homeostasis and regeneration[J]. Nat Rev Mol Cell Biol, 2014,15(1):19-33.
    [15] Riehl T, Cohn S, Tessner T, et al. Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism[J]. Gastroenterology, 2000,118(6):1106-1016.
    [16] Walker MR, Brown SL, Riehl TE, et al. Growth factor regulation of prostaglandin-endoperoxide synthase 2(Ptgs2) expression in colonic mesenchymal stem cells[J]. J Biol Chem, 2010,285(7):5026-5039.
    [17] Zhang X, Schwarz EM, Young DA, et al. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair[J]. J Clin Invest, 2002,109(11):1405-1415.
    [18] Kurtova AV, Xiao J, Mo Q, et al. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance[J]. Nature, 2015,517(7533):209-213.
    [19] Houchen CW, Sturmoski MA, Anant S, et al. Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine[J]. Am J Physiol Gastrointest Liver Physiol, 2003,284(3):G490-498.
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  • 收稿日期:  2015-09-06
  • 修回日期:  2015-10-21

辐射所致肠道损伤中环氧酶作用的研究进展

doi: 10.3969/j.issn.1006-0111.2016.03.001
  • 第二军医大学附属长征医院药学部, 上海 200003
    • 基金项目:  上海市科学技术委员会科研计划项目(12401900704)
  • 收稿日期: 2015-09-06
  • 修回日期: 2015-10-21

摘要: 胃肠道对辐射高度敏感;防治辐射所致的胃肠道组织损伤一直是放射生物学领域探究的热点。以往研究表明,环氧酶对辐射引起的肠组织损伤有重要的保护作用。笔者就环氧酶在辐射所致肠道损伤中的作用及其机制做一综述。

English Abstract

陶玉龙, 杨宏, 陶霞. 辐射所致肠道损伤中环氧酶作用的研究进展[J]. 药学实践与服务, 2016, 34(3): 193-195. doi: 10.3969/j.issn.1006-0111.2016.03.001
引用本文: 陶玉龙, 杨宏, 陶霞. 辐射所致肠道损伤中环氧酶作用的研究进展[J]. 药学实践与服务, 2016, 34(3): 193-195. doi: 10.3969/j.issn.1006-0111.2016.03.001
shu
TAO Yulong, YANG Hong, TAO Xia. Role of cyclooxygenases in radiation enteropathy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 193-195. doi: 10.3969/j.issn.1006-0111.2016.03.001
Citation: TAO Yulong, YANG Hong, TAO Xia. Role of cyclooxygenases in radiation enteropathy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 193-195. doi: 10.3969/j.issn.1006-0111.2016.03.001
shu

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