留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

心肌缺血的昼夜节律性与时辰疗法

张恩晖,  王海峰,  陈莉,  刘佃花,  于剑光,  蔡国君

downloadPDF
文章导航 > 药学实践与服务  > 2016 >  34(1): 8-11,47
张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
引用本文: 张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu
ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu

心肌缺血的昼夜节律性与时辰疗法

doi: 10.3969/j.issn.1006-0111.2016.01.003
  • 1.

    第二军医大学药学院药理学教研室, 上海 200433;解放军203医院药械科, 黑龙江 齐齐哈尔 161000

  • 2.

    解放军203医院药械科, 黑龙江 齐齐哈尔 161000

  • 3.

    第二军医大学药学院药理学教研室, 上海 200433

Circadian rhythms of myocardial ischemia and chronotherapy

  • 1.

    Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China;Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China

  • 2.

    Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China

  • 3.

    Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China

  • 摘要: 临床上心肌缺血(MI)的发作频率伴有昼夜变化,在清晨和傍晚是发病高峰期。产生这一现象主要是受到机体病理生理机制的昼夜节律性以及外界的环境因素影响。目前β-受体阻断剂、硝酸酯类以及钙通道阻滞剂等药物的治疗作用已经被证明受到机体昼夜节律的影响。因此,笔者对MI发作的昼夜节律特点、病理生理机制以及目前临床上的时辰疗法进行综述,并对未来的治疗策略进行探讨。
    Abstract: The occurrence of the clinical manifestations of myocardial ischemia shows clear circadian rhythmicity, and they are unevenly distributed during the 24 h with higher morbidity during the initial hours of the daily activity span and in the late afternoon or early evening. Such temporal patterns result from circadian rhythms in pathophysiological mechanisms plus cyclic environmental stressors that trigger these clinical events. β-receptor antagonist medications, oral nitrate, and calcium channel blocker have been shown to be influenced by the circadian time of their administration. Here we briefly review the characteristics of circadian rhythmicity in MI, the pathophysiological mechanisms as well as the current chronotherapy,and then discuss the future treatment strategies.
  • [1] Portaluppi F,Manfredini R,Fersini C.From a static to a dynamic concept of risk:the circadian epidemiology of cardiovascular events[J].Chronobiol Int,1999,16(1):33-49.
    [2] Haus E,Sackett-Lundeen L,Smolensky MH.Rheumatoid arthritis:circadian rhythms in disease activity,signs and symptoms,and rationale for chronotherapy with corticosteroids and other medications[J].Bull NYU Hosp Jt Dis,2012,70(Suppl 1):3-10.
    [3] Mori H,Nakamura N,Tamura N,et al.Circadian variation of basal total vascular tone and chronotherapy in patients with vasospastic angina pectoris[J].Biomed Pharmacother,2002,56(Suppl 2):339s-344s.
    [4] Thome C,Vajkoczy P,Horn P,et al.Continuous monitoring of regional cerebral blood flow during temporary arterial occlusion in aneurysm surgery[J].J Neurosurg,2001,95(3):402-411.
    [5] Araki H,Koiwaya Y,Nakagaki O,et al.Diurnal distribution of ST-segment elevation and related arrhythmias in patients with variant angina:a study by ambulatory ECG monitoring[J].Circulation,1983,67(5):995-1000.
    [6] Joy M,Pollard CM,Nunan TO.Diurnal variation in exercise responses in angina pectoris[J].Br Heart J,1982,48(2):156-160.
    [7] Ogawa H,Yasue H,Oshima S,et al.Circadian variation of plasma fibrinopeptide A level in patients with variant angina[J].Circulation,1989,80(6):1617-1626.
    [8] Kusama Y,Kodani E,Nakagomi A,et al.Variant angina and coronary artery spasm:the clinical spectrum, pathophysiology,and management[J].J Nippon Med Sch, 2011,78(1):4-12.
    [9] Edahiro R,Sakata Y,Nakatani D,et al.Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction:a prospective observational study in Japan[J].BMJ Open,2014,4(6):e005067.
    [10] Selvi Y,Smolensky MH,Boysan M,et al.Role of patient chronotype on circadian pattern of myocardial infarction:a pilot study[J].Chronobiol Int,2011,28(4):371-377.
    [11] Behar S,Halabi M,Reicher-Reiss H,et al.Circadian variation and possible external triggers of onset of myocardial infarction.SPRINT Study Group[J].Am J Med,1993,94(4):395-400.
    [12] Gilpin EA,Hjalmarson A,Ross JJr.Subgroups of patients with atypical circadian patterns of symptom onset in acute myocardial infarction[J].Am J Cardiol,1990,66(16):7G-11G.
    [13] Hjalmarson A,Gilpin EA,Nicod P,et al.Differing circadian patterns of symptom onset in subgroups of patients with acute myocardial infarction[J].Circulation,1989,80(2):267-275.
    [14] Kanth R,Ittaman S,Rezkalla S.Circadian patterns of ST elevation myocardial infarction in the new millennium[J].Clin Med Res,2013,11(2):66-72.
    [15] Kinjo K,Sato H,Sato H,et al.Circadian variation of the onset of acute myocardial infarction in the Osaka area,1998-1999:characterization of morning and nighttime peaks[J].Jpn Circ J,2001,65(7):617-620.
    [16] Trappolini M,Matteoli S,Borgia MC,et al.Circadian variations in the onset of acute myocardial infarction[J]. Minerva Cardioangiol,2001,49(5):289-296.
    [17] Cohen MC,Rohtla KM,Lavery CE,et al.Meta-analysis of the morning excess of acute myocardial infarction and sudden cardiac death[J].Am J Cardiol,1997,79(11):1512-1516.
    [18] Arntz HR,Willich SN,Oeff M,et al.Circadian variation of sudden cardiac death reflects age-related variability in ventricular fibrillation[J].Circulation,1993,88(5 Pt 1):2284-2289.
    [19] Willich SN,Goldberg RJ,Maclure M,et al.Increased onset of sudden cardiac death in the first three hours after awakening[J].Am J Cardiol,1992,70(1):65-68.
    [20] Hansen O,Johansson BW,Gullberg B.The clinical outcome of acute myocardial infarction is related to the circadian rhythm of myocardial infarction onset[J].Angiology,1993,44(7):509-516.
    [21] Fujita M,Araie E,Yamanishi K,et al.Circadian variation in the success rate of intracoronary thrombolysis for acute myocardial infarction[J].Am J Cardiol,1993,71(15):1369-1371.
    [22] Cooke-Ariel H.Circadian variations in cardiovascular function and their relation to the occurrence and timing of cardiac events[J].Am J Health Syst Pharm,1998,55(Suppl 3):5-11.
    [23] Furlan R,Guzzetti S,Crivellaro W,et al.Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects[J].Circulation,1990,81(2):537-547.
    [24] Yasue H,Touyama M,Kato H,et al.Prinzmetal's variant form of angina as a manifestation of alpha-adrenergic receptor-mediated coronary artery spasm:documentation by coronary arteriography[J].Am Heart J,1976,91(2):148-155.
    [25] Wolk R,Gami AS,Garcia-Touchard A,et al.Sleep and cardiovascular disease[J].Curr Probl Cardiol,2005,30(12):625-662.
    [26] Hilfenhaus M.Circadian rhythm of the renin-angiotensin-aldosterone system in the rat[J].Arch Toxicol,1976,36(3-4):305-316.
    [27] Cugini P,Lucia P.Circadian rhythm of the renin-angiotensin-aldosterone system:a summary of our research studies[J].ClinTer,2004,155(7-8):287-291.
    [28] Vaughan DE,Lazos SA,Tong K.Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells.A potential link between the renin-angiotensin system and thrombosis[J].J Clin Invest,1995,95(3):995-1001.
    [29] Brown NJ,Kim KS,Chen YQ,et al.Synergistic effect of adrenal steroids and angiotensin II on plasminogen activator inhibitor-1 production[J].J Clin Endocrinol Metab,2000,85(1):336-344.
    [30] Clow A,Hucklebridge F,Stalder T,et al.The cortisol awakening response:more than a measure of HPA axis function[J].Neurosci Biobehav Rev,2010,35(1):97-103.
    [31] Wilhelm I,Born J,Kudielka BM,et al.Is the cortisol awakening rise a response to awakening?[J].Psychoneuroendocrinology,2007,32(4):358-366.
    [32] Champaneri S,Xu X,Carnethon MR,et al.Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus:the Multi-Ethnic Study of Atherosclerosis[J].Metabolism,2012,61(7):986-995.
    [33] Sahna E,Parlakpinar H,Turkoz Y,et al.Protective effects of melatonin on myocardial ischemia/reperfusion induced infarct size and oxidative changes[J].Physiol Res,2005,54(5):491-495.
    [34] Buxton OM,L'Hermite-Balériaux M,Turek FW,et al.Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion[J].Am J Physiol Regul Integr Comp Physiol,2000,278(2):373-382.
    [35] Ludka O,Spinar J,Pozdisek Z,et al.Is there circadian variation of big endothelin and NT-proBNP in patients with severe congestive heart failure？[J]. Vnitr Lek,2010,56(6):488-493.
    [36] Tofler GH,Brezinski D,Schafer AI,et al.Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death[J].N Engl J Med,1987,316(24):1514-1518.
    [37] Quyyumi AA,Crake T,Wright CM,et al.Medical treatment of patients with severe exertional and rest angina:double blind comparison of beta blocker,calcium antagonist,and nitrate[J].Br Heart J,1987,57(6):505-511.
    [38] Conte G,Rigon N,Perrone A.Application of chronotherapy to cardiovascular diseases [J].Recenti Prog Med,1998,89(9):465-469.
    [39] Kuwajima I,Abe K.Effects of the long-acting calcium channel blocker barnidipine hydrochloride on 24-h ambulatory blood pressure[J].Blood Press Monit,2002,7(1):63-65.
  • [1] 石晓萍, 吕迁洲, 李晓宇, 许青.  泊沙康唑对比伏立康唑经验治疗或诊断驱动治疗免疫功能低下患者侵袭性霉菌病的成本-效果分析 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202401050
    [2] 杨嘉宁, 赵一颖, 肖伟.  七味脂肝方对非酒精性脂肪性肝炎动物模型的药效学评价 . 药学实践与服务, 2024, 42(9): 389-398. doi: 10.12206/j.issn.2097-2024.202404096
    [3] 迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛.  负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
    [4] 戴菲菲, 傅翔, 陈琼年, 俞苏纯.  上海某二级医院革兰阴性菌流行特征的回顾性分析 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202305005
    [5] 唐淑慧, 凤美娟, 薛智霞, 鲁桂华.  帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究 . 药学实践与服务, 2024, 42(5): 217-222. doi: 10.12206/j.issn.2097-2024.202311029
    [6] 桂明珠, 李静, 李志玲.  儿童伏立康唑的血药浓度与CYP2C19、CYP2C9和CYP3A5基因多态性的相关性研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402020
    [7] 孙丹倪, 黄勇, 张嘉宝, 王培.  代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049
    [8] 王耀振, 徐灿, 吕顺莉, 田泾, 张东炜.  钾离子竞争性酸阻滞剂的药学特征研究进展 . 药学实践与服务, 2024, 42(7): 278-284. doi: 10.12206/j.issn.2097-2024.202306040
    [9] 张晶晶, 索丽娜, 郑兆红.  89例细菌性肝脓肿的临床特征及抗感染治疗分析 . 药学实践与服务, 2024, 42(6): 267-272. doi: 10.12206/j.issn.2097-2024.202302039
    [10] 徐璐璐, 刘爱军.  丹参白术方“异病同治”冠心病、血管性痴呆、特发性膜性肾病的网络药理学作用机制研究 . 药学实践与服务, 2024, 42(12): 1-8. doi: 10.12206/j.issn.2097-2024.202312027
    [11] 刘丽艳, 余小翠, 孙传铎.  纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
    [12] 张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英.  二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
    [13] 丁华敏, 郭羽晨, 秦春霞, 宋志兵, 孙莉莉.  消风止痒颗粒通过降低白三烯水平对小鼠特应性皮炎急性瘙痒的治疗作用研究 . 药学实践与服务, 2024, 42(5): 211-216. doi: 10.12206/j.issn.2097-2024.202306031
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3662
  • HTML全文浏览量:  407
  • PDF下载量:  125
  • 被引次数: 0
出版历程
  • 收稿日期:  2014-09-19
  • 修回日期:  2015-04-28

心肌缺血的昼夜节律性与时辰疗法

doi: 10.3969/j.issn.1006-0111.2016.01.003
  • 1. 第二军医大学药学院药理学教研室, 上海 200433;解放军203医院药械科, 黑龙江 齐齐哈尔 161000
  • 2. 解放军203医院药械科, 黑龙江 齐齐哈尔 161000
  • 3. 第二军医大学药学院药理学教研室, 上海 200433
  • 收稿日期: 2014-09-19
  • 修回日期: 2015-04-28

摘要: 临床上心肌缺血(MI)的发作频率伴有昼夜变化,在清晨和傍晚是发病高峰期。产生这一现象主要是受到机体病理生理机制的昼夜节律性以及外界的环境因素影响。目前β-受体阻断剂、硝酸酯类以及钙通道阻滞剂等药物的治疗作用已经被证明受到机体昼夜节律的影响。因此,笔者对MI发作的昼夜节律特点、病理生理机制以及目前临床上的时辰疗法进行综述,并对未来的治疗策略进行探讨。

English Abstract

张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
引用本文: 张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu
ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu

    全文HTML

参考文献 (39)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计