CYP2C19基因多态性对药物代谢影响的研究进展

彭净; 刘卫

doi:10.3969/j.issn.1006-0111.2015.06.008

CYP2C19基因多态性对药物代谢影响的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.008

彭净¹,
刘卫^2,

1.
解放军88医院, 山东泰安 271000;济宁医学院附属医院, 山东济宁 272000
2.
解放军88医院, 山东泰安 271000

基金项目: 山东省药学会奥赛康中青年临床药师资助项目(No.sdpa-ask-2013-02)

Research progress in the effect of CYP2C19 gene polymorphisms on drug metabolism

PENG Jing¹,
LIU Wei^2
,

1.
No. 88 Hospital of PLA, Taian 271000, China;Affiliated Hospital of Jining Medical University, Ji'ning 272000, China
2.
No. 88 Hospital of PLA, Taian 271000, China

摘要: 药物代谢和相互作用的差异与CYP的单核苷酸基因多态性有关。综述CYP2C19基因多态性对质子泵抑制剂、抗真菌药伏立康唑、抗血小板药氯吡格雷的代谢和药物相互作用的影响,以期为个体化用药提供参考。
- CYP2C19 /
- 基因多态性 /
- 质子泵抑制剂 /
- 伏立康唑 /
- 氯吡格雷
Abstract: Drug metabolism and drug-drug interactions were associated with the single nucleotide polymorphisms of CYP. The relationship between CYP2C19 polymorphisms and metabolism as well as interactions of proton pump inhibitors, voriconazole and clopidogrel were reviewed to provide evidence for personalized medication.
- CYP2C19 /
- polymorphism /
- proton pump inhibitor /
- voriconazole /
- clopidogrel

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CYP2C19基因多态性对药物代谢影响的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.008

Research progress in the effect of CYP2C19 gene polymorphisms on drug metabolism

计量

CYP2C19基因多态性对药物代谢影响的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.008

1. 解放军88医院, 山东泰安 271000;济宁医学院附属医院, 山东济宁 272000

2. 解放军88医院, 山东泰安 271000

English Abstract

Research progress in the effect of CYP2C19 gene polymorphisms on drug metabolism

1. No. 88 Hospital of PLA, Taian 271000, China;Affiliated Hospital of Jining Medical University, Ji'ning 272000, China

2. No. 88 Hospital of PLA, Taian 271000, China

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CYP2C19基因多态性对药物代谢影响的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.008

Research progress in the effect of CYP2C19 gene polymorphisms on drug metabolism

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CYP2C19基因多态性对药物代谢影响的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.008

1. 解放军88医院, 山东 泰安 271000;济宁医学院附属医院, 山东 济宁 272000 2. 解放军88医院, 山东 泰安 271000

English Abstract

Research progress in the effect of CYP2C19 gene polymorphisms on drug metabolism

1. No. 88 Hospital of PLA, Taian 271000, China;Affiliated Hospital of Jining Medical University, Ji'ning 272000, China 2. No. 88 Hospital of PLA, Taian 271000, China

全文HTML

目录

1. 解放军88医院, 山东泰安 271000;济宁医学院附属医院, 山东济宁 272000

2. 解放军88医院, 山东泰安 271000

1. No. 88 Hospital of PLA, Taian 271000, China;Affiliated Hospital of Jining Medical University, Ji'ning 272000, China

2. No. 88 Hospital of PLA, Taian 271000, China