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蛇毒毒素的抗肿瘤作用及其在医药领域的应用

金夕琳 张洁 江海龙 陆一鸣

金夕琳, 张洁, 江海龙, 陆一鸣. 蛇毒毒素的抗肿瘤作用及其在医药领域的应用[J]. 药学实践与服务, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
引用本文: 金夕琳, 张洁, 江海龙, 陆一鸣. 蛇毒毒素的抗肿瘤作用及其在医药领域的应用[J]. 药学实践与服务, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
JIN Xilin, ZHANG Jie, JIANG Hailong, LU Yiming. The antitumor effect of snake venom toxins and its application in medical field[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
Citation: JIN Xilin, ZHANG Jie, JIANG Hailong, LU Yiming. The antitumor effect of snake venom toxins and its application in medical field[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006

蛇毒毒素的抗肿瘤作用及其在医药领域的应用

doi: 10.3969/j.issn.1006-0111.2015.06.006
基金项目: 国家自然科学基金项目(No.81274162,30500093);国家科技部“重大新药创制”专项(No.2009ZX09103-690);上海市科委重点项目(No.04JC14002);军队“十一五”计划(No.06Q042);上海市高校优秀青年教师科研专项基金(No.ejd09011)

The antitumor effect of snake venom toxins and its application in medical field

  • 摘要: 目的 探讨蛇毒毒素的抗肿瘤作用及其在医药领域的应用。 方法 综述蛇毒毒素的抗肿瘤组分、抗肿瘤作用及其机制的研究进展。 结果 蛇毒毒素对多种肿瘤均有抑制作用,具有直接杀伤肿瘤细胞、诱导肿瘤细胞凋亡、抑制血管再生等作用。 结论 对蛇毒毒素抗肿瘤组分及其作用机制进行深入研究,是当前抗肿瘤药物研究的重要方向。
  • [1] Matsui T, Fujimura Y, Koiti T. Snake venom proteases aiecting hemostasis and thrombosis[J].Biochim Biophys Acta,2000, 1477(1-2):146-156.
    [2] Lauterwein J.Wuthrich K.A possible structural basis for the difierdnt models of action of neurotoxins and carditotoxins from snake venon1[J].FEBS Lett,1978,93(2):181-184.
    [3] Jokhio R,Ansari AF.Cobra snake venom reduces significantly tissue nucleic acid levels in human breast cancer[J].J Pak Med Assoc,2005,55(2):71-73.
    [4] Xie Q,Wan R,Lin X,et al.Effects of snake venom cystatin gene on gene expression profiles in mouse melanoma cell line B16F1[J].Chin Cancer,2008,27(7):716-722.
    [5] da Sliva RJ,da Sliva MG,Vilela LC,et al.Antitumor efect of Bothrops jararaca venom[J].Mediators Inflamm,2002,11(2):99-104.
    [6] Kini RM.Platelet aggregation and exogenous factors from animalsources[J].Curr Drug Targ Cardiovasc Haematol Disord,2004,4(4):301-325.
    [7] de Carvalho DD, Schmitmeier S, Novello JC, et al.Effect of BJcuL (a lectin from the venom of the snake Bothrops jararacussu) on adhesion and growth of tumor and endothelial cells[J].Toxicon, 2001, 39(10): 1471-1476.
    [8] Torii S,Naito M, Tsuruo T. Apoxin I,a novel apoptosis inducingfactor with L-amino acid oxidase activity purified from western diamondback rattlesnake venom[J].Biol Chem,1997,272(14):9539-9542.
    [9] Guo CM, Liu SQ, Yao YW. Past decade study of snake venom L-amino acid oxidase[J].Toxicon, 2012, 60(3) : 302-311.
    [10] Samel M, Vija H, Rönnholm G,et al. Isolation and characterization of an apoptotic and platelet aggregation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom[J].Biochim Biophys Acta,2006, 1764(4):707-714.
    [11] Kanzawa N,Shintani S,Ohta K,et al. Achacin induces cell death in HeLa cells through two different mechanisms[J].Arch Biochem Biophys,2004, 422(1): 103-109.
    [12] Alves RM, Antonucci GA, Paiva HH,et al. Evidence of caspase mediatedapoptosis induced by L-amino acid oxidase isolated fromBothrops atrox snake venom[J].Comp Biochem Physiol A,2008,151(4):542-550.
    [13] de Melo Alves Paiva R, de Freitas Figueiredo R, Antonucci GA,et al. Cell cycle arrest evidence, parasiticidal and bactericidal properties induced by L-amino acid oxidase from Bothrops atrox snake venom[J].Bchimie,2011, 93(5): 941-947.
    [14] Zhang L, Wu WT. Isolation and characterization of ACTX-6:a cytotoxic L-amino acid oxidase from Agkistrodonacutus snake venom[J].Nat Prod Res,2008, 22(6): 554-563.
    [15] Chen X, Lv P, Liu J, et al. Apoptosis of human hepatocellular carcinoma cell (HepG2) induced by cardiotoxin III through sphase arrest [J].Toxicol Pathol, 2009,61(4): 307-315.
    [16] Zhang L, Cui L. A cytotoxin isolated from Agkistrodonacutus snake venom induces apoptosis via Fas pathway in A549 cells[J].Toxicol In Vitro, 2007,21(6): 1095-1103.
    [17] Golubkov V, Hawes D, Markland FS. Anti-angiogenic activity ofeontortrostatin,a disintegrin from Agkistrodon contortrix snake venom[J].Angiogenesis,2003,6(3):213-224.
    [18] Yeh CH,Peng HC,Yang RS,et al .Rhodostomin,a snake venom disintegrin,inhibits angiogenesis elicited by basic fibroblast growthfactor and suppresses tumor growth by a selective alpha(v)beta(3) blockade of endothelial cells[J].Mol Pharmacol,2001,59(5):1333-1342.
    [19] Zhang L, Cui L. A cytotoxin isolated from Agkistrodonacutus snake venom induces apoptosis via Fas pathway in A549 cells[J].Toxicol In Vitro, 2007,21(6): 1095-1103.
    [20] El-Refaei MF, Sarkar NH. Snake venom inhibits the growth of mouse mammary tumor cells in vitro and in vivo[J].Toxicon, 2009,54(1): 33-41.
    [21] de Melo Alves Paiva R, de Freitas Figueiredo R, Antonucci GA,et al. Cell cycle arrest evidence, parasiticidal and bactericidal properties induced by L-amino acid oxidase from Bothrops atrox snake venom[J].Bchimie,2011, 93(5): 941-947.
    [22] Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target[J]. Nature,2005,438(7070): 967-974.
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蛇毒毒素的抗肿瘤作用及其在医药领域的应用

doi: 10.3969/j.issn.1006-0111.2015.06.006
    基金项目:  国家自然科学基金项目(No.81274162,30500093);国家科技部“重大新药创制”专项(No.2009ZX09103-690);上海市科委重点项目(No.04JC14002);军队“十一五”计划(No.06Q042);上海市高校优秀青年教师科研专项基金(No.ejd09011)

摘要: 目的 探讨蛇毒毒素的抗肿瘤作用及其在医药领域的应用。 方法 综述蛇毒毒素的抗肿瘤组分、抗肿瘤作用及其机制的研究进展。 结果 蛇毒毒素对多种肿瘤均有抑制作用,具有直接杀伤肿瘤细胞、诱导肿瘤细胞凋亡、抑制血管再生等作用。 结论 对蛇毒毒素抗肿瘤组分及其作用机制进行深入研究,是当前抗肿瘤药物研究的重要方向。

English Abstract

金夕琳, 张洁, 江海龙, 陆一鸣. 蛇毒毒素的抗肿瘤作用及其在医药领域的应用[J]. 药学实践与服务, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
引用本文: 金夕琳, 张洁, 江海龙, 陆一鸣. 蛇毒毒素的抗肿瘤作用及其在医药领域的应用[J]. 药学实践与服务, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
JIN Xilin, ZHANG Jie, JIANG Hailong, LU Yiming. The antitumor effect of snake venom toxins and its application in medical field[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
Citation: JIN Xilin, ZHANG Jie, JIANG Hailong, LU Yiming. The antitumor effect of snake venom toxins and its application in medical field[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
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