rhGM-CSF凝胶对LEEP治疗宫颈上皮内瘤变创面愈合的影响

郑洁; 朱珍珍; 虞如芬

doi:10.3969/j.issn.1006-0111.2014.02.013

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

rhGM-CSF凝胶对LEEP治疗宫颈上皮内瘤变创面愈合的影响

郑洁, 朱珍珍, 虞如芬

文章导航 > 药学实践与服务 > 2014 > 32(2): 124-127

郑洁, 朱珍珍, 虞如芬. rhGM-CSF凝胶对LEEP治疗宫颈上皮内瘤变创面愈合的影响[J]. 药学实践与服务, 2014, 32(2): 124-127. doi: 10.3969/j.issn.1006-0111.2014.02.013

引用本文:

郑洁, 朱珍珍, 虞如芬. rhGM-CSF凝胶对LEEP治疗宫颈上皮内瘤变创面愈合的影响[J]. 药学实践与服务, 2014, 32(2): 124-127. doi: 10.3969/j.issn.1006-0111.2014.02.013

ZHENG Jie, ZHU Zhenzhen, YU Rufen. The influence of rhGM-CSF gel to curing the CIN wound healing[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 124-127. doi: 10.3969/j.issn.1006-0111.2014.02.013

Citation:

ZHENG Jie, ZHU Zhenzhen, YU Rufen. The influence of rhGM-CSF gel to curing the CIN wound healing[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 124-127. doi: 10.3969/j.issn.1006-0111.2014.02.013

rhGM-CSF凝胶对LEEP治疗宫颈上皮内瘤变创面愈合的影响

doi: 10.3969/j.issn.1006-0111.2014.02.013

1.
瑞安市中医院, 浙江瑞安 325200
2.
温州医学院附属第三医院, 浙江瑞安 325200

The influence of rhGM-CSF gel to curing the CIN wound healing

1.
Ruian Hospital of traditional Chinese medicine, Ruian 325200, China
2.
The Third Hospital Affiliated to Wenzhou Medical College, Ruian 325200, China

摘要: 目的研究外用重组人粒细胞-巨噬细胞刺激因子(recombinant human granulocyte/macrophage colony-stimulating factor, rhGM-CSF)凝胶对子宫颈电热圈环切术(LEEP)治疗宫颈上皮内瘤变(CIN)术后创口愈合的影响。方法选择CIN患者124例,分为治疗组(73例)和对照组(51例),均用LEEP治疗,术后创口分别敷用rhGM-CSF凝胶和无菌纱布,观察两组创面愈合情况(阴道出血时间和出血量、创面止血结痂初步愈合时间)、疗效、并发症发生率,并统计分析数据。结果治疗组和对照组阴道出血持续时间≤2周、2~3周、3~5周和>5周的发生率分别为93.15%和23.52%、5.48%和41.18%、1.37%和17.39%、0.00%和13.73%,两组患者阴道出血量≤20 ml、21~49 ml和>50 ml的发生率分别为91.78%和27.45%、8.22%和62.75%、0.00%和9.80%,两组患者创面愈合平均时间分别为(8.1±2.4)d和(17.7±3.5)d,差异均有统计学意义(P<0.05);6个月后随访,两组有效率分别为98.63%和86.27%(P<0.05);两组并发症发生率分别为1.37%和13.73%(P<0.05)。结论 rhGM-CSF可促进LEEP刀治疗CIN术后创面的愈合,减少并发症的发生率。
- 重组人粒细胞-巨噬细胞刺激因子 /
- 凝胶 /
- 子宫颈电热圈环切术 /
- 宫颈上皮内瘤变
Abstract: Objective To study the influence of external recombinant human granulocyte/macrophage colony-stimulating factor (rhGM-CSF) gel on wound healing after LEEP for curing the CIN. Methods 124 patients with CIN were selected and divided into two groups:the treatment group (73 cases) and the control group (51 cases). Both two groups were treated by LEEP, and the wound were covered by rhGM-CSF gel and sterile gauze, respectively. And then, the wound healing status of these two groups (the bleeding time and amount of vagina, preliminary healing time of wound callusing), curative effect and incidence of complications of these two groups were observed,and analyzed. Results The incidence of vaginal bleeding in both treatment group and control group whose bleeding time ≤ 2 weeks, >2weeks but ≤ 3weeks, >3weeks but ≤ 5 weeks, >5 weeks were 93.15% vs 23.52%, 5.48% vs 41.18%, 1.37% vs 17.39% and 0.00% vs 13.73%, respectively. The incidence of vaginal bleeding amount in both groups whose amount ≤ 20 ml, 21-49 ml and > 50 ml were 91.78% vs 27.45%, 8.22% vs 62.75% and 0.00% vs 9.80%, respectively. The average time for the wound healing of both groups were 8.1±2.4 days and 17.7±3.5 days, and these differences were all had statistical significance(P<0.05). The effective rates were 98.63% and 86.27%(P<0.05) when the patients were visited after 6 months. The incidence of complications were 1.37% and 13.73%(P<0.05), respectively. Conclusion rhGM-CSF could accelerate the wound healing of CIN patients after LEEP, and reduce the incidence of complications.

[1]	Johnson N,Khalili M,Hirschwitz L,et al.Predicting residual disease after rexcision of cervical dysplasia[J].Int J Obstetr Gynec,2003,110(10):952-955.
[2]	乐杰.妇产科学[M].7版.北京:人民卫生出版社,2008:262-263.
[3]	陈炯,韩春茂,陈国贤,等.重组人粒细胞-巨噬细胞集落刺激因子凝胶剂促进深Ⅱ度烧伤愈合[J].中华创伤杂志,2008,24,(3):224-227.
[4]	王志勇,张勤,廖镇江,等.重组人粒细胞-巨噬细胞集落刺激因子对深Ⅱ度烧伤创面的治疗作用[J].中华烧伤杂志,2008,24(2):107:107-110.
[5]	Mann A,Breuhahn K,Schirmacher P,et al.Keratinocyte-derived granulocyte-macropage colony stimulating factor accelrates wound healing:stimulation and vascularization[J].J Invest Dermatol,2001,117(6):1382-1390.
[6]	Jaschke E,Zabernigg A,Gattringer C.Recmbinant human graulocyte-macrophage colony-stimulating faactor applied locally in low doses enhances healing and prevents recurrence of chronic venous ulcers[J].Int J Dermatol,1999,38(5):380-386.
[7]	欧邦军,梁自乾.胰岛素联合表皮生长因子治疗糖尿病性烧伤创面的研究进展[J].实用医学杂志,2010,26(8):1448-1450.
[8]	郭敏,崔文慧,徐祥,等.小鼠急性皮肤缺损创面粒-巨噬细胞集落刺激因子表达特点及其作用机制[J].中华创伤杂志,2011,27(7):648-653.
[9]	Groves RW,Schmidt-Lucke JA.Recombinant human GM-CSF in the treatment of poorly healing wounds[J].Adv Skin Wound Care,2000,13(3):107-112.
[10]	Fang Y,Cong SJ,Xu YH,et al.Impaired cutaneous wound healing in granulocyte/macrophage colony-stimulating factor knockout mice[J].Br J Dermatol,2007,157(3):458-465.
[11]	程志华,程小平,彭文,等.富林蜜与外用重组人粒细胞-巨噬细胞刺激因子凝胶联合应用治疗深Ⅱ度烧伤临床观察[J].中华损伤与修复杂志,2011,6(2):259-263.
[12]	赵洪猛,张斌,冯锐,等.巨噬细胞及粒细胞巨噬细胞集落刺激因子促进大鼠腹壁动脉穿支皮瓣存活的作用及其机制[J].中华实验外科杂志,2011,28(5):687.
[13]	兰海霞,博晓真,新燕,等.粒细胞-巨噬细胞集落刺激因子的研究进展[J].临床儿科杂志,2005,2(12):64-66.
[14]	邱学文,王甲汉,杨磊,等.重组人粒细胞-巨噬细胞集落刺激因子治疗烧伤后残余创面[J].实用医学杂志,2011,27(7):1195-1196.
[15]	Mann A,Niekisch K,Schirmacher P,et al.Granulocyte-macrophage colony-stimulating factor is essential for normal wound healing[J].J Invest Dermatol Symp Proc,2006,11(1):82-92.

[1]	毛智毅, 王筱燕, 陈晓颖, 汤逸斐. 度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
[2]	陈怡君, 王卓, 何苗, 张宇, 田泾. 泌尿系统碎石术抗菌药物预防使用合理管控实践 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402034
[3]	刘丽艳, 余小翠, 孙传铎. 纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
[4]	宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅. 帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
[5]	冯志惠, 邓仪卿, 叶冰, 安培, 张宏, 张海军. 雀梅藤石油醚提取物诱导三阴性乳腺癌细胞凋亡的实验研究 . 药学实践与服务, 2024, 42(6): 253-259. doi: 10.12206/j.issn.2097-2024.202311055
[6]	修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星. 全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 291-296. doi: 10.12206/j.issn.2097-2024.202312054
[7]	姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量. 巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
[8]	杨媛媛, 安晓强, 许佳捷, 江键, 梁媛媛. 正极性驻极体联合5-氟尿嘧啶对瘢痕成纤维细胞生长抑制的协同作用 . 药学实践与服务, 2024, 42(6): 244-247. doi: 10.12206/j.issn.2097-2024.202310027
[9]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034

点击查看大图

计量

文章访问数: 2328
HTML全文浏览量: 267
PDF下载量: 55
被引次数: 0

rhGM-CSF凝胶对LEEP治疗宫颈上皮内瘤变创面愈合的影响

doi: 10.3969/j.issn.1006-0111.2014.02.013

1. 瑞安市中医院, 浙江瑞安 325200

2. 温州医学院附属第三医院, 浙江瑞安 325200

收稿日期: 2013-07-30
修回日期: 2013-11-02

关键词:

重组人粒细胞-巨噬细胞刺激因子 /

凝胶 /

子宫颈电热圈环切术 /

宫颈上皮内瘤变

摘要: 目的研究外用重组人粒细胞-巨噬细胞刺激因子(recombinant human granulocyte/macrophage colony-stimulating factor, rhGM-CSF)凝胶对子宫颈电热圈环切术(LEEP)治疗宫颈上皮内瘤变(CIN)术后创口愈合的影响。方法选择CIN患者124例,分为治疗组(73例)和对照组(51例),均用LEEP治疗,术后创口分别敷用rhGM-CSF凝胶和无菌纱布,观察两组创面愈合情况(阴道出血时间和出血量、创面止血结痂初步愈合时间)、疗效、并发症发生率,并统计分析数据。结果治疗组和对照组阴道出血持续时间≤2周、2~3周、3~5周和>5周的发生率分别为93.15%和23.52%、5.48%和41.18%、1.37%和17.39%、0.00%和13.73%,两组患者阴道出血量≤20 ml、21~49 ml和>50 ml的发生率分别为91.78%和27.45%、8.22%和62.75%、0.00%和9.80%,两组患者创面愈合平均时间分别为(8.1±2.4)d和(17.7±3.5)d,差异均有统计学意义(P<0.05);6个月后随访,两组有效率分别为98.63%和86.27%(P<0.05);两组并发症发生率分别为1.37%和13.73%(P<0.05)。结论 rhGM-CSF可促进LEEP刀治疗CIN术后创面的愈合,减少并发症的发生率。

English Abstract

The influence of rhGM-CSF gel to curing the CIN wound healing

1. Ruian Hospital of traditional Chinese medicine, Ruian 325200, China

2. The Third Hospital Affiliated to Wenzhou Medical College, Ruian 325200, China

Received Date: 2013-07-30
Rev Recd Date: 2013-11-02

Keywords:

Abstract: Objective To study the influence of external recombinant human granulocyte/macrophage colony-stimulating factor (rhGM-CSF) gel on wound healing after LEEP for curing the CIN. Methods 124 patients with CIN were selected and divided into two groups:the treatment group (73 cases) and the control group (51 cases). Both two groups were treated by LEEP, and the wound were covered by rhGM-CSF gel and sterile gauze, respectively. And then, the wound healing status of these two groups (the bleeding time and amount of vagina, preliminary healing time of wound callusing), curative effect and incidence of complications of these two groups were observed,and analyzed. Results The incidence of vaginal bleeding in both treatment group and control group whose bleeding time ≤ 2 weeks, >2weeks but ≤ 3weeks, >3weeks but ≤ 5 weeks, >5 weeks were 93.15% vs 23.52%, 5.48% vs 41.18%, 1.37% vs 17.39% and 0.00% vs 13.73%, respectively. The incidence of vaginal bleeding amount in both groups whose amount ≤ 20 ml, 21-49 ml and > 50 ml were 91.78% vs 27.45%, 8.22% vs 62.75% and 0.00% vs 9.80%, respectively. The average time for the wound healing of both groups were 8.1±2.4 days and 17.7±3.5 days, and these differences were all had statistical significance(P<0.05). The effective rates were 98.63% and 86.27%(P<0.05) when the patients were visited after 6 months. The incidence of complications were 1.37% and 13.73%(P<0.05), respectively. Conclusion rhGM-CSF could accelerate the wound healing of CIN patients after LEEP, and reduce the incidence of complications.