Therapy on male delayed puberty caused by hypogonadotropic hypogonadism by combination of growth hormone and gonadotropin
-
摘要: 目的 探讨生长激素联合促性腺激素治疗男性低促性腺激素性腺功能低下而引起青春期发育迟滞的临床应用价值。 方法 回顾性分析2010年6月~2012年5月我院门诊就诊男性青春期发育迟滞患者28例,年龄(15.25±1.11)岁,经明确诊断后予生长激素、卵泡刺激素、人绒毛膜促性腺激素联合治疗。比较治疗前后患者性激素水平、身高、睾丸体积等发育情况变化。 结果 28例患者治疗后均得到随访,3个月内随访未出现近期并发症。治疗前后患者身高和睾酮水平均有显著升高(P<0.05);睾丸体积、卵泡刺激素和黄体生成素水平有极显著升高(P<0.01)。 结论 生长激素、卵泡刺激素、人绒毛膜促性腺激素联合治疗方案对男性低促性腺激素性腺功能低下引起青春期发育迟滞有一定疗效,是临床可行的安全的治疗方案。
-
关键词:
- 青春期发育迟滞 /
- 促性腺激素性腺功能低下症 /
- 生长激素 /
- 促性腺激素
Abstract: Objective To evaluate the value and safety of combined therapy of growth hormone and gonadotropin on male delayed puberty caused by hypogonadotropic hypogonadism. Methods A retrospective analysis was undergoing in Shanghai First Maternity and Infant Hospital from 2010 Jun to 2012 May. 28 cases with male delayed puberty caused by hypogonadotropic hypogonadism were enrolled. The average age was (15.25±1.11) years. All the cases were given a combined therapy of human chorionic gonadotrophin, follicle stimulating hormone and growth hormone. After 3 months therapy, the growth condition such as sexual hormone levels, height, and volume of testis were recorded to inspect the treatment effect. Results All 28 cases had a follow-up visit. No short term complications occurred. The height and testosterone level was higher than which before therapy (P<0.05). And the volume of testis, follicle stimulating hormone and luteinizing hormone level were significantly higher than before the therapy. Conclusion Combined therapy of human chorionic gonadotrophin, follicle stimulating hormone and growth hormone could be a safe and effective method to treat male delayed puberty caused by hypogonadotropic hypogonadism.-
Key words:
- male delayed puberty /
- hypogonadotropic hypogonadism /
- growth hHormone /
- gonadotropin
-
[1] Silveira LF, MacColl GS, Bouloux PM. Hypogonadotropic hypogonadism[J]. Semin Reprod Med,2002, 20(4):327. [2] 杨念钦, 王国民. HCG-FSH联合治疗低促性腺激素性性腺功能减退症29例报告[J]. 中国男科学, 2009, 23(12):39. [3] 狄福松, 崔毓桂, 贾 悦. 促性腺激素治疗男性低促性腺激素性性腺功能减退症的疗效评估[J]. 中华内科杂志,2005, 44(11):836. [4] Wang GM, O`Shaughnessy PJ, Chubb C, et al. Effects of insulin like growth factor-I on steroidogenic enzyme expression levels in mouse Leydig cells[J]. Endocrinology,2003, 144(11): 5058. [5] Warne DW, Decosterd G, Okada H, et al. A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle-stimulating hormone and human chorionic gonadotropin[J]. Fertil Steril, 2009, 92:594. [6] Kanzaki M, Morris PL. Growth hormone regulates steroidogenic acute regulatory protein expression and steroidogenesis in Leydig cell progenitors[J]. Endocrinology,1999, 140(4):1681. [7] Zheng JX, Liu ZZ, Yang N. Deficiency of growth hormone receptor does not affect male reproduction in dwarf chickens[J]. Poult Sci,2007, 86(1):112. -
点击查看大图
计量
- 文章访问数: 2747
- HTML全文浏览量: 309
- PDF下载量: 82
- 被引次数: 0
下载:
