Keywords: 
• alendronate sodium and vitamin D₃ tablets /
• salmon calcitonin nasal spray /
• zoledronicacid injection /
• osteoporosis /
• pharmaco-economics

Abstract: Objective To investigate economic effects of three kinds of drugs in treatment of osteoporosis. Methods 135 cases were divided into three groups, A group with alendronate sodium and vitamin D₃ tablets 70 mg/2 800 IU, once a week, early morning,B group with salmon calcitonin nasal spray, once a day every time 100 IU, C group with zoledronicacid injection 4 mg, once a year. All groups were treated for one year, three groups of patients were added calcium at the same time. Efficacy was observed. Cost-effectiveness analysis was used. Results In the improvement of bone pain, A group was 66.67%, B group was 55.56%, C group was 80%. C group was higher than those in group A, group B, group efficacy was statistically significant in three groups(P<0.05); The effectiveness ratio of A group, B group, C group was 59.52,43.61,46.70 respectively. B group was superior to A group and C group in the terms of economic, but group B had the lowest efficacy in all groups. Conclusion C group was the optimal solution for osteoporosis.