二氧化钛微囊防晒霜的研制

孟慧; 许勇

doi:10.3969/j.issn.1006-0111.2012.01.010

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二氧化钛微囊防晒霜的研制

孟慧, 许勇

文章导航 > 药学实践与服务 > 2012 > 30(1): 38-41

孟慧, 许勇. 二氧化钛微囊防晒霜的研制[J]. 药学实践与服务, 2012, 30(1): 38-41. doi: 10.3969/j.issn.1006-0111.2012.01.010

引用本文:

孟慧, 许勇. 二氧化钛微囊防晒霜的研制[J]. 药学实践与服务, 2012, 30(1): 38-41. doi: 10.3969/j.issn.1006-0111.2012.01.010

MENG Hei, XU Yong. Preparation of Polyelectrolyte microcapsules of TiO2 sunscreen cream[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 38-41. doi: 10.3969/j.issn.1006-0111.2012.01.010

Citation:

MENG Hei, XU Yong. Preparation of Polyelectrolyte microcapsules of TiO₂ sunscreen cream[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 38-41. doi: 10.3969/j.issn.1006-0111.2012.01.010

二氧化钛微囊防晒霜的研制

doi: 10.3969/j.issn.1006-0111.2012.01.010

孟慧,
许勇

解放军第85医院药剂科,上海 200052

基金项目: 南京军区医药卫生科研基金(面上课题第09ma002号).

Preparation of Polyelectrolyte microcapsules of TiO₂ sunscreen cream

MENG Hei,
XU Yong

Department of Pharmaceutics, 85th Hospital of PLA, Shanghai 200336, China

摘要: 目的制备含纳米二氧化钛的聚电解质微囊防晒霜,并考察制剂的结构和防晒性能。方法以碳酸钙粒子为核心,通过静电吸附原理将聚电解质4-苯乙烯磺酸钠和纳米二氧化钛交替逐层包裹在核心表面形成微囊,加入辅料,按常规方法制备防晒霜。利用扫描电镜和共聚焦显微镜观察微囊结构;防晒系数分析仪测定制剂的防晒性能。结果二氧化钛微囊外观圆整,平均粒径为(5.46±1.05) μm,微囊防晒霜防晒SPF值为30.31±2.56。结论含纳米二氧化钛的聚电解质微囊防晒霜防晒的效果优于普通二氧化钛防晒霜。
- 二氧化钛 /
- 微囊 /
- 防晒系数
Abstract: Objective To investigate the preparation method, the structure and the sun protection factor (SPF) of the polyelectrolyte self-assembled microcapsules containing TiO₂ nanoparticles. Methods Calcium carbonate was used as the core, and the semipermeable membrane outside the core was made of poly (sodium 4-styrenesulfonate) (PSS) and TiO₂ depositing onto the core surface alternately through electrostatic attraction. The morphology and the structure of the microcapsules were obtained by confocal laser scanning microscopy and scanning electron microscopy. The SPF was tested by SPF-290 analytical system. Results The prepared microcapsules were well-shaped with a mean diameter of (5.46±1.05) μm. The SPF was 30.31±2.56. Conclusion It was indicated that in comparison with traditional TiO₂ sunscreen cream, the polyelectrolyte microcapsules containing titania had powerful absorbance of the ultraviolet rays.
- TiO₂ /
- microcapsules /
- SPF

[1]	Touitou E, Godin B. Skin nonpenetrating sunscreens for cosmetic and pharmaceutical formulations[J].Clin Dermatol, 2008, 26(4):375.
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[6]	张晟卯, 张治军, 党鸿辛,等.磺化聚苯乙烯/二氧化钛有序交替纳米复合多层膜的制备、结构表征及其微观摩擦学行为[J].河南大学学报, 2003, 3(1):38.
[7]	Sukhorukov GB, Volodkin DV, Gunther AM, et al. Porouscalcium carbonate microparticles as templates for encapsulation of bioactive compounds[J].J Mater Chem, 2004, 14(14): 2073.
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二氧化钛微囊防晒霜的研制

doi: 10.3969/j.issn.1006-0111.2012.01.010

孟慧,
许勇

解放军第85医院药剂科,上海 200052

基金项目: 南京军区医药卫生科研基金(面上课题第09ma002号).

收稿日期: 2011-08-22
修回日期: 2011-11-01

关键词:

二氧化钛 /

微囊 /

防晒系数

摘要: 目的制备含纳米二氧化钛的聚电解质微囊防晒霜,并考察制剂的结构和防晒性能。方法以碳酸钙粒子为核心,通过静电吸附原理将聚电解质4-苯乙烯磺酸钠和纳米二氧化钛交替逐层包裹在核心表面形成微囊,加入辅料,按常规方法制备防晒霜。利用扫描电镜和共聚焦显微镜观察微囊结构;防晒系数分析仪测定制剂的防晒性能。结果二氧化钛微囊外观圆整,平均粒径为(5.46±1.05) μm,微囊防晒霜防晒SPF值为30.31±2.56。结论含纳米二氧化钛的聚电解质微囊防晒霜防晒的效果优于普通二氧化钛防晒霜。