摘要:
目的: 观察芬太尼透皮贴剂与曲马多用于日间肛门手术病人的术后镇痛效果及安全性。 方法: 120例日间接受腰麻下行肛门手术病人随机分为芬太尼透皮贴剂术后镇痛组(A组),术后3h口服曲马多100mg镇痛组(B组),以及对照组术后不予镇痛(C组)。采用VAS评分评价术后不同时点镇痛效果、采用Ramsay评分评价术后不同时点镇静效果,同时观察不良反应发生情况。 结果: 术后4、24、48 h时A组和B组镇痛效果优于C组,术后24、48 h时A组镇痛效果优于B组和C组,术后24、48 h时A组镇静效果优于B组和C组,术后24 h时B组镇静效果优于C组,不良反应发生率仅头晕嗜睡A组与C组间差异有统计学意义。 结论: 芬太尼透皮贴剂是日间肛门手术病人术后镇痛的一种应用安全、方法简单、镇痛、镇静效果好的药物剂型。
关键词:
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肛门 /
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手术 /
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镇痛 /
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芬太尼透皮贴剂 /
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曲马多
Abstract:
Objective To observe the analgesia effect and safety of Fentanyl Transdermal System and tramadol for day surgery patients with anus surgeries. Methods 120 cases of anus surgeries undergo spinal anesthesia were randomly divided into three groups.Patients of group A had Fentanyl Transdermal System affixed on for analgesia.Patients of group B were received an oral dose of 100 mg tramadol in 3 h after operation.Patients of group C had no analgesia.The analgesia effects of three groups were estimated with VAS score after operation in different time points.The sedation effects of three groups were estimated with Ramsay score after operation in different time points,while observing the occurrence of adverse reactions. Results The analgesia effect of group A and group B were superior to group C at 4,24,48 h after operation.But the analgesia effect of group A was superior to group B and group C at 24,48 h after operation.The sedation effect of group A was superior to group B and group C at 24,48 h after operation.And the sedation effect of group B was superior to group C at 24 h after operation.Only dizziness and drowsiness was higher significantly between group A and group C in the the incidence of adverse reactions.Methods The Fentanyl Transdermal System was a safe,simple and better effect medicament for ease the pain undergo the anus surgeries of day-case.
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