摘要:
目的: 研究通脉愈伤胶囊的镇痛、抗炎作用。 方法: 采用二甲苯造成小鼠急性炎症模型,角叉菜胶、皮下包埋棉球法分别造成大鼠急、慢性炎症模型。采用热板法、腹腔注射醋酸法造成疼痛模型;将实验动物分为5组:空白对照组,阳性对照云南白药胶囊组,高、中、低剂量通脉愈伤胶囊组。以考察通脉愈伤胶囊的抗炎、镇痛效果。 结果: 通脉愈伤胶囊能显著降低小鼠毛细血管通透性,减少炎性介质的渗出;明显抑制由二甲苯引起的小鼠耳廓肿胀及角叉菜胶所致的大鼠炎症反应,降低白细胞数目;对大鼠肉芽组织增生也有显著的抑制作用。通脉愈伤胶囊能提高小鼠痛阈,延长镇痛潜伏期,降低扭体次数,镇痛率分别为49.6%、43.5%、33.3%。 结论: 通脉愈伤胶囊具有良好的抗炎、镇痛作用。
Abstract:
Objective To study the anti-inflammatory and analgesic effects of Tongmaiyushang capsule. Methods Tumidness of small rat ears was induced by dimethylbenzene.Acute and chronic inflammation of rats were induced by carrageenin and tampon embedding respectively.The pain model was made by hot plate and writhing tests.Animals were divided into five groups: the blank control group;the positive control group;the low,middle and high dose of Tongmaiyushang capsule groups to investigate the anti-inflammatory and analgesic effect of the Tongmaiyushang capsule. Results The capillary permeability was decreased and the effusion of inflammatory mediator was reduced in small rat.Tumidness of small rat ears caused by dimethylbenzene and inflammation reaction induced by carrageenin were significantly inhibited with the reduction of leukocytes.The hyperplasia of granulation tissue in rats was also be inhibited.The capsule could improve the threshold of pain,prolong the incubation period of pain,decrease the quantity of body wrest of small rats.The analgesia rate of three groups was 49.6%,43.5%,33.3%,respectively. Conclusion Tongmaiyushang capsule has good anti-inflammatory and analgesic effects.
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