摘要:
目的 比较单、复凝聚法制备微囊的外观性状和包封率,为进一步研究微囊的制备工艺打下基础.方法 以酮康唑作为囊芯物,用明胶和阿拉伯胶作囊材,采用常规的单、复凝聚法分别制备酮康唑微囊,并在光学显微镜下比较其外观性状;采用单波长紫外分光光度法建立微囊中酮康唑含量测定方法,在此基础上计算其药物包封率.结果 2种方法所得的微囊均为白色粉末,采用单凝聚法得到的微囊平均粒径为32.20μm,相对包封率为6.11%;复凝聚法制备的微囊则分别为7.99μm和83.42%.结论 采用相分离-凝聚法制备微囊时,复凝聚法所得结果较好.
关键词:
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微囊 /
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单凝聚法 /
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复凝聚法 /
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酮康唑
Abstract:
Objective To compare the microcapsules produced by single coacervation with that produced by complex coacervation, to sure which method was better.Methods Using ketoconazole as core, and the gelatin-acacia gum as the sealing material, microcapsules were produced by single coacervation and complex coacervation respectively.Their shape and diameter were observed under the microscope, and the concentration of ketoconazole was measured by UV spectrophotomelry, their microencapsulating rates were also determinated.Results Microcapsules were white powder either produced by single coacervation or complex one.The diameter and microencapsulating rate of microcapsules produced by single coacerva tion were 32.20μm and 56.11% respectively, while 7.99μm and 83.42% were detected among the microcapsules produced by complex coacervation.Conclusion When microcapsules are prepared by the phase separation-coacervation, the complex coacervation is better.
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