摘要:
目的 探讨拉米夫定(贺普丁)联合苦参素(博尔泰力)治疗慢性乙型肝炎的临床疗效及安全性。方法67例患者被随机分为治疗组36例,给予贺普丁100mg·d-1,po,同时加用苦参素600mg·d-1,im,3mo为一疗程:对照组31例单用拉米夫定,其用法及时间与治疗组相同。结果 疗程结束时,观察患者肝功能、乙型肝炎病毒血清学(HBVM)标志的变化。 2组患者血清谷丙转氨酶(ALT)的复常率分别为90.2%和75.3%,HBeAg阴转率分别为33.4%和16.1%,治疗组疗效明显优于对照组(P <0.05),未见严重不良反应。 结论 拉米夫定联合苦参素具有显着改善肝功能及抑制乙肝病毒复制等功效,建议二者联合应用以作为慢性乙型肝炎的一种治疗方案,更深入的研究,待进一步验证。
Abstract:
OBJECTIVE To study the efficacy and safety of lamivudine combination with oxymatrine in treating chronic hepatitis B.METHODS 67 patients were randomly divided into 2 groups.36 patients as a treatment group received 100mg·d-1,po,lamivudine combination with 600mg·d-1,im oxymatrine for 3 months.31 patients as a control group was treated only with routine therapy.RESULTS After completion of therapy,the change of liver function and mark of HBVM were observed.In the two groups,the recovery rate of ALT was 90.2% and 75.3%,the negative rate of HBeAg was 33.4% and 16.1%.The efficacy of the treatment group was higher than that of control group.(P<0.05).Side effects had not been found.CONCLUSION lamivudine combination with oxymatrine can improve the liver function and inhibit HBV.
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