双波长分光光度法测定复方萘酚喹片中甲氧苄啶含量
Determination of trimethoprim in compound naphthoquine tablets by di-wavelength spectrophotosmetry
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摘要: 目的 建立复方萘酚喹片中甲氧苄啶含量测定的方法。方法 测定波长为271nm,参比波长为361nm。结果 线性范围为6.24~31.20μg/ml,r=0.9999(n=6),平均回收率为100.9%,RSD为0.24%(n=6).结论 该法操作简便、快捷、准确,适用于其含量和溶出度的测定。Abstract: OBJECTIVE To develop a method for determination of trimethoprim in compound naphthoquine Tablets.METHODS Detected at 271nm, with referenced wavelength at 361nm. RESULTS Within 6.24~31.20μg/ml, TMP had a good linearity (r=0.9999).The average recovery was 100.9%, with the RSD of 0.24%(n=6).CONCLUSION The method was simple, rapid, accurate, and can be used both as the determination of content and the determination of dissolve.
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