褪黑激素明胶微球剂与溶液剂鼻粘膜给药比较
Comparison of the differences between melatonin gelatin microspheres and solution in nasal delivery system
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摘要: 目的 比较明胶微球剂与溶液剂的鼻粘膜给药。方法 通过鼻粘膜滞留时间及药物鼻粘膜吸收等实验,比较明胶微球及溶液2种给药制剂的区别。结果 明胶微球剂在鼻粘膜滞留时间明显比溶液剂长,能明显提高药物鼻粘膜吸收,并延长药物在体内滞留时间。结论 明胶微球明显提高药物鼻粘膜吸收,具有很好应用前景。Abstract: OBJECTIVE To compare the differences between gelatin microspheres and solution in nasal delivery system. METHODS The residence time in nasal mucosa and nasal absorption experiments were performed respectively to compare the differences between gelatin microspheres and solution. RESIJLTS The residence time of gelatin microspheres was longer than gelatin solution in nasal cavity, gelatin microspheres evidently raised melatonin nasal absorption and prolonged the retention time in blood circulation. CONCLUTION Gelatin microspheres could raise melatonin nasal absorption and would have good application prospects.
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Key words:
- gelatin microspheres /
- solution /
- nasally administration
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