摘要:
本文对旱柳叶的化学成分及其生物活性进行了研究,从中分离鉴定出11种单体化合物并对其中3种化合物,即芹菜素-7-O-β-D-吡喃葡萄糖醛酸苷(Ⅰ)、木樨草素-7-O-β-D-吡喃葡萄糖醛酸苷(Ⅱ)、间-羟基-苄基-吡喃葡萄糖苷(Ⅲ)的生物活性进行了考察。化合物Ⅰ、Ⅱ、Ⅲ均可选择性抑制花生四烯酸代谢产物12-HETE的生成;化合物(Ⅰ)水解后的苷元-芹菜素对TXB2的生成有一定的抑制作用,但对12-HETE的生成无抑制作用。小鼠饲喂高脂肪饲料,一周以后体重明显增加。饲喂高脂肪饲料添加旱柳叶活性组分抑制小鼠体重和子宫周围脂肪量的增加,而且还可以降低肝中胆固醇和中性脂肪的含量。化合物Ⅲ对大鼠脂肪细胞中由去甲肾上腺素(NE)诱导的脂类分解有促进作用。
Abstract:
From the leaves of Salix matsdana,three known compounds,apigenin-7-O-β-D-glucopyranuronide(Ⅰ),luteolin-7-O-β-D-glucopyranuronide(Ⅱ),were isolated at first in the Salix spp.Other compound(Ⅲ),was isolated in the leaves of Salix matsdana and proposed as p-phenol-methyl-O-β-D-glycoside, Furthermore, we studied on effect of arachidonic acid metabolism in rat platelets by compoundⅠ、Ⅱ and Ⅲ with radio-chromatography and found that these compounds can significantly inhibit the production of 12-HETE(12-hydroxy-5,8,10,14-eicosatetraenoic acid), which can induced allergy and atheroselero-sis.The production of apigenin-7-O-β-D-glucopyranuroide being hydrolyzed was apigenin, which can inhibit not only 12-HETE but also TXB2(thromboxane B2) which can induce platelet aggregation.
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